4O4D

Crystal Structure of an Inositol hexakisphosphate kinase EhIP6KA in complexed with ATP and Ins(1,4,5)P3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000824	molecular_function	inositol tetrakisphosphate 3-kinase activity
A	0000828	molecular_function	inositol hexakisphosphate kinase activity
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0008440	molecular_function	inositol-1,4,5-trisphosphate 3-kinase activity
A	0016301	molecular_function	kinase activity
A	0032958	biological_process	inositol phosphate biosynthetic process
A	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 401

Chain	Residue
A	ASP231
A	ATP404
A	HOH595
A	HOH604
A	HOH605

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 402

Chain	Residue
A	ASP231
A	ATP404
A	HOH610
A	HOH613

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site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE I3P A 403

Chain	Residue
A	LYS101
A	LYS115
A	LYS118
A	ARG119
A	ARG152
A	TYR153
A	HIS234
A	GLU242
A	ATP404
A	ACT406
A	HOH617
A	HOH641
A	HOH644
A	HOH654

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site_id	AC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ATP A 404

Chain	Residue
A	LEU36
A	LYS38
A	PHE77
A	MET85
A	GLU86
A	ASN87
A	LEU88
A	ASP99
A	ASP231
A	MG401
A	MG402
A	I3P403
A	HOH580
A	HOH604
A	HOH605
A	HOH610
A	HOH613
A	HOH617
A	HOH661

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site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PO4 A 405

Chain	Residue
A	HIS73
A	HIS73
A	HIS73
A	HIS73
A	HOH515
A	HOH515
A	HOH515
A	HOH596
A	HOH596
A	HOH596
A	HOH596

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site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACT A 406

Chain	Residue
A	THR106
A	ASP108
A	THR111
A	ARG119
A	SER207
A	HIS234
A	I3P403
A	HOH581

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