4NU0
Crystal structure of Adenylate kinase from Streptococcus pneumoniae with Ap5A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004017 | molecular_function | adenylate kinase activity |
| A | 0004127 | molecular_function | cytidylate kinase activity |
| A | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006225 | biological_process | UDP biosynthetic process |
| A | 0009123 | biological_process | nucleoside monophosphate metabolic process |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016776 | molecular_function | phosphotransferase activity, phosphate group as acceptor |
| A | 0019205 | molecular_function | nucleobase-containing compound kinase activity |
| A | 0033862 | molecular_function | UMP kinase activity |
| A | 0044209 | biological_process | AMP salvage |
| A | 0046705 | biological_process | CDP biosynthetic process |
| A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| A | 0050145 | molecular_function | nucleoside monophosphate kinase activity |
| B | 0004017 | molecular_function | adenylate kinase activity |
| B | 0004127 | molecular_function | cytidylate kinase activity |
| B | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| B | 0006225 | biological_process | UDP biosynthetic process |
| B | 0009123 | biological_process | nucleoside monophosphate metabolic process |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016776 | molecular_function | phosphotransferase activity, phosphate group as acceptor |
| B | 0019205 | molecular_function | nucleobase-containing compound kinase activity |
| B | 0033862 | molecular_function | UMP kinase activity |
| B | 0044209 | biological_process | AMP salvage |
| B | 0046705 | biological_process | CDP biosynthetic process |
| B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| B | 0050145 | molecular_function | nucleoside monophosphate kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 301 |
| Chain | Residue |
| A | AP5302 |
| A | HOH402 |
| A | HOH416 |
| A | HOH442 |
| A | HOH452 |
| site_id | AC2 |
| Number of Residues | 40 |
| Details | BINDING SITE FOR RESIDUE AP5 A 302 |
| Chain | Residue |
| A | LYS13 |
| A | GLY14 |
| A | THR15 |
| A | THR31 |
| A | GLY32 |
| A | PHE35 |
| A | ARG36 |
| A | ILE53 |
| A | GLU57 |
| A | VAL59 |
| A | THR64 |
| A | GLY86 |
| A | TYR87 |
| A | ARG89 |
| A | GLN93 |
| A | ARG124 |
| A | ARG128 |
| A | THR137 |
| A | PHE138 |
| A | HIS139 |
| A | PHE142 |
| A | ARG156 |
| A | ARG167 |
| A | GLN195 |
| A | ILE197 |
| A | MG301 |
| A | HOH402 |
| A | HOH404 |
| A | HOH416 |
| A | HOH432 |
| A | HOH442 |
| A | HOH482 |
| A | HOH521 |
| A | HOH539 |
| A | HOH587 |
| A | HOH591 |
| A | PRO9 |
| A | GLY10 |
| A | ALA11 |
| A | GLY12 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 301 |
| Chain | Residue |
| B | AP5302 |
| B | HOH405 |
| B | HOH501 |
| B | HOH554 |
| B | HOH593 |
| site_id | AC4 |
| Number of Residues | 42 |
| Details | BINDING SITE FOR RESIDUE AP5 B 302 |
| Chain | Residue |
| B | PRO9 |
| B | GLY10 |
| B | ALA11 |
| B | GLY12 |
| B | LYS13 |
| B | GLY14 |
| B | THR15 |
| B | THR31 |
| B | GLY32 |
| B | PHE35 |
| B | ARG36 |
| B | ILE53 |
| B | GLU57 |
| B | LEU58 |
| B | VAL59 |
| B | THR64 |
| B | GLY86 |
| B | TYR87 |
| B | ARG89 |
| B | GLN93 |
| B | ARG124 |
| B | LEU125 |
| B | ARG128 |
| B | THR137 |
| B | PHE138 |
| B | HIS139 |
| B | PHE142 |
| B | ARG156 |
| B | ARG167 |
| B | GLN195 |
| B | ILE197 |
| B | MG301 |
| B | HOH404 |
| B | HOH405 |
| B | HOH419 |
| B | HOH426 |
| B | HOH481 |
| B | HOH553 |
| B | HOH554 |
| B | HOH558 |
| B | HOH574 |
| B | HOH593 |
Functional Information from PROSITE/UniProt
| site_id | PS00113 |
| Number of Residues | 12 |
| Details | ADENYLATE_KINASE Adenylate kinase signature. FLLDGYPRtieQ |
| Chain | Residue | Details |
| A | PHE82-GLN93 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00235 |
| Chain | Residue | Details |
| A | GLY86 | |
| A | GLN93 | |
| A | ARG128 | |
| A | THR137 | |
| A | ARG156 | |
| A | ARG167 | |
| A | GLN195 | |
| B | GLY10 | |
| B | THR31 | |
| B | ARG36 | |
| B | GLU57 | |
| B | GLY86 | |
| B | GLN93 | |
| B | ARG128 | |
| B | THR137 | |
| B | ARG156 | |
| B | ARG167 | |
| B | GLN195 | |
| A | GLY10 | |
| A | THR31 | |
| A | ARG36 | |
| A | GLU57 |
