Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0050518 | molecular_function | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity |
| A | 0070567 | molecular_function | cytidylyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CD A 401 |
| Chain | Residue |
| A | GLU167 |
| A | GLU167 |
| A | K411 |
| A | K411 |
| A | HOH518 |
| A | HOH518 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CD A 402 |
| Chain | Residue |
| A | HOH507 |
| A | GLU121 |
| A | GLU191 |
| A | HIS271 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 403 |
| Chain | Residue |
| A | ASP289 |
| A | ARG296 |
| A | GLU300 |
| A | HOH595 |
| A | HOH624 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K A 404 |
| Chain | Residue |
| A | SER117 |
| A | MET119 |
| A | VAL122 |
| A | ASP145 |
| A | VAL146 |
| A | HOH540 |
| A | HOH567 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K A 405 |
| Chain | Residue |
| A | ASP189 |
| A | LEU205 |
| A | GLN235 |
| A | GLY278 |
| A | SER279 |
| A | ASN282 |
| A | K406 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 406 |
| Chain | Residue |
| A | VAL185 |
| A | ASN186 |
| A | ASP189 |
| A | ASN282 |
| A | K405 |
| A | HOH501 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 407 |
| Chain | Residue |
| A | ARG182 |
| A | PRO183 |
| A | LEU184 |
| A | VAL185 |
| A | ASN282 |
| A | ILE283 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 408 |
| Chain | Residue |
| A | ILE108 |
| A | ALA109 |
| A | SER112 |
| A | SER180 |
| A | PRO183 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K A 409 |
| Chain | Residue |
| A | SER112 |
| A | THR115 |
| A | PRO183 |
| A | VAL185 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE K A 410 |
| Chain | Residue |
| A | ALA199 |
| A | ALA199 |
| A | ALA199 |
| A | HOH538 |
| A | HOH538 |
| A | HOH538 |
| A | HOH575 |
| A | HOH575 |
| A | HOH575 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K A 411 |
| Chain | Residue |
| A | GLN166 |
| A | GLU167 |
| A | GLU167 |
| A | CD401 |
| A | CD401 |
| A | HOH518 |
| A | HOH520 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE K A 412 |
| Chain | Residue |
| A | GLU156 |
| A | GLU258 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE K A 413 |
| Chain | Residue |
| A | GLU191 |
| A | HOH554 |
| A | HOH593 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K A 414 |
| Chain | Residue |
| A | SER163 |
| A | GLU167 |
| A | HOH509 |
| A | HOH553 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE K A 415 |
| Chain | Residue |
| A | ARG149 |
| A | ILE168 |
| A | HOH588 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 416 |
| Chain | Residue |
| A | LYS123 |
| A | ASP147 |
| A | HOH541 |
| A | HOH550 |
| A | HOH568 |
| A | HOH631 |
Functional Information from PROSITE/UniProt
| site_id | PS01295 |
| Number of Residues | 8 |
| Details | ISPD 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature. VCIHDSAR |
| Chain | Residue | Details |
| A | VAL175-ARG182 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Transition state stabilizer => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG91 | |
| A | LYS98 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Positions MEP for the nucleophilic attack => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG228 | |
| A | LYS284 | |
