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4N9F

Crystal structure of the Vif-CBFbeta-CUL5-ElOB-ElOC pentameric complex

Functional Information from GO Data
ChainGOidnamespacecontents
00000122biological_processnegative regulation of transcription by RNA polymerase II
00000209biological_processprotein polyubiquitination
00001503biological_processossification
00001649biological_processosteoblast differentiation
00003677molecular_functionDNA binding
00003713molecular_functiontranscription coactivator activity
00005515molecular_functionprotein binding
00005634cellular_componentnucleus
00005654cellular_componentnucleoplasm
00006357biological_processregulation of transcription by RNA polymerase II
00006366biological_processtranscription by RNA polymerase II
00016020cellular_componentmembrane
00016513cellular_componentcore-binding factor complex
00030098biological_processlymphocyte differentiation
00030099biological_processmyeloid cell differentiation
00043371biological_processnegative regulation of CD4-positive, alpha-beta T cell differentiation
00043378biological_processpositive regulation of CD8-positive, alpha-beta T cell differentiation
00043565molecular_functionsequence-specific DNA binding
00045944biological_processpositive regulation of transcription by RNA polymerase II
00048469biological_processcell maturation
00060216biological_processdefinitive hemopoiesis
10003723molecular_functionRNA binding
10005515molecular_functionprotein binding
10016020cellular_componentmembrane
10019058biological_processviral life cycle
10020002cellular_componenthost cell plasma membrane
10030430cellular_componenthost cell cytoplasm
10044423cellular_componentvirion component
20003723molecular_functionRNA binding
20005515molecular_functionprotein binding
20016020cellular_componentmembrane
20019058biological_processviral life cycle
20020002cellular_componenthost cell plasma membrane
20030430cellular_componenthost cell cytoplasm
20044423cellular_componentvirion component
30006511biological_processubiquitin-dependent protein catabolic process
30031625molecular_functionubiquitin protein ligase binding
40006368biological_processtranscription elongation by RNA polymerase II
40030891cellular_componentVCB complex
40070449cellular_componentelongin complex
50006511biological_processubiquitin-dependent protein catabolic process
60000122biological_processnegative regulation of transcription by RNA polymerase II
60000209biological_processprotein polyubiquitination
60001503biological_processossification
60001649biological_processosteoblast differentiation
60003677molecular_functionDNA binding
60003713molecular_functiontranscription coactivator activity
60005515molecular_functionprotein binding
60005634cellular_componentnucleus
60005654cellular_componentnucleoplasm
60006357biological_processregulation of transcription by RNA polymerase II
60006366biological_processtranscription by RNA polymerase II
60016020cellular_componentmembrane
60016513cellular_componentcore-binding factor complex
60030098biological_processlymphocyte differentiation
60030099biological_processmyeloid cell differentiation
60043371biological_processnegative regulation of CD4-positive, alpha-beta T cell differentiation
60043378biological_processpositive regulation of CD8-positive, alpha-beta T cell differentiation
60043565molecular_functionsequence-specific DNA binding
60045944biological_processpositive regulation of transcription by RNA polymerase II
60048469biological_processcell maturation
60060216biological_processdefinitive hemopoiesis
70003723molecular_functionRNA binding
70005515molecular_functionprotein binding
70016020cellular_componentmembrane
70019058biological_processviral life cycle
70020002cellular_componenthost cell plasma membrane
70030430cellular_componenthost cell cytoplasm
70044423cellular_componentvirion component
90006511biological_processubiquitin-dependent protein catabolic process
90031625molecular_functionubiquitin protein ligase binding
a0000122biological_processnegative regulation of transcription by RNA polymerase II
a0000209biological_processprotein polyubiquitination
a0001503biological_processossification
a0001649biological_processosteoblast differentiation
a0003677molecular_functionDNA binding
a0003713molecular_functiontranscription coactivator activity
a0005515molecular_functionprotein binding
a0005634cellular_componentnucleus
a0005654cellular_componentnucleoplasm
a0006357biological_processregulation of transcription by RNA polymerase II
a0006366biological_processtranscription by RNA polymerase II
a0016020cellular_componentmembrane
a0016513cellular_componentcore-binding factor complex
a0030098biological_processlymphocyte differentiation
a0030099biological_processmyeloid cell differentiation
a0043371biological_processnegative regulation of CD4-positive, alpha-beta T cell differentiation
a0043378biological_processpositive regulation of CD8-positive, alpha-beta T cell differentiation
a0043565molecular_functionsequence-specific DNA binding
a0045944biological_processpositive regulation of transcription by RNA polymerase II
a0048469biological_processcell maturation
a0060216biological_processdefinitive hemopoiesis
b0003723molecular_functionRNA binding
b0005515molecular_functionprotein binding
b0016020cellular_componentmembrane
b0019058biological_processviral life cycle
b0020002cellular_componenthost cell plasma membrane
b0030430cellular_componenthost cell cytoplasm
b0044423cellular_componentvirion component
B0006511biological_processubiquitin-dependent protein catabolic process
c0000122biological_processnegative regulation of transcription by RNA polymerase II
c0000209biological_processprotein polyubiquitination
c0001503biological_processossification
c0001649biological_processosteoblast differentiation
c0003677molecular_functionDNA binding
c0003713molecular_functiontranscription coactivator activity
c0005515molecular_functionprotein binding
c0005634cellular_componentnucleus
c0005654cellular_componentnucleoplasm
c0006357biological_processregulation of transcription by RNA polymerase II
c0006366biological_processtranscription by RNA polymerase II
c0016020cellular_componentmembrane
c0016513cellular_componentcore-binding factor complex
c0030098biological_processlymphocyte differentiation
c0030099biological_processmyeloid cell differentiation
c0043371biological_processnegative regulation of CD4-positive, alpha-beta T cell differentiation
c0043378biological_processpositive regulation of CD8-positive, alpha-beta T cell differentiation
c0043565molecular_functionsequence-specific DNA binding
c0045944biological_processpositive regulation of transcription by RNA polymerase II
c0048469biological_processcell maturation
c0060216biological_processdefinitive hemopoiesis
C0006511biological_processubiquitin-dependent protein catabolic process
C0031625molecular_functionubiquitin protein ligase binding
d0003723molecular_functionRNA binding
d0005515molecular_functionprotein binding
d0016020cellular_componentmembrane
d0019058biological_processviral life cycle
d0020002cellular_componenthost cell plasma membrane
d0030430cellular_componenthost cell cytoplasm
d0044423cellular_componentvirion component
D0006368biological_processtranscription elongation by RNA polymerase II
D0030891cellular_componentVCB complex
D0070449cellular_componentelongin complex
e0006368biological_processtranscription elongation by RNA polymerase II
e0030891cellular_componentVCB complex
e0070449cellular_componentelongin complex
E0006511biological_processubiquitin-dependent protein catabolic process
f0006511biological_processubiquitin-dependent protein catabolic process
f0031625molecular_functionubiquitin protein ligase binding
F0000122biological_processnegative regulation of transcription by RNA polymerase II
F0000209biological_processprotein polyubiquitination
F0001503biological_processossification
F0001649biological_processosteoblast differentiation
F0003677molecular_functionDNA binding
F0003713molecular_functiontranscription coactivator activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0006357biological_processregulation of transcription by RNA polymerase II
F0006366biological_processtranscription by RNA polymerase II
F0016020cellular_componentmembrane
F0016513cellular_componentcore-binding factor complex
F0030098biological_processlymphocyte differentiation
F0030099biological_processmyeloid cell differentiation
F0043371biological_processnegative regulation of CD4-positive, alpha-beta T cell differentiation
F0043378biological_processpositive regulation of CD8-positive, alpha-beta T cell differentiation
F0043565molecular_functionsequence-specific DNA binding
F0045944biological_processpositive regulation of transcription by RNA polymerase II
F0048469biological_processcell maturation
F0060216biological_processdefinitive hemopoiesis
g0006368biological_processtranscription elongation by RNA polymerase II
g0030891cellular_componentVCB complex
g0070449cellular_componentelongin complex
G0003723molecular_functionRNA binding
G0005515molecular_functionprotein binding
G0016020cellular_componentmembrane
G0019058biological_processviral life cycle
G0020002cellular_componenthost cell plasma membrane
G0030430cellular_componenthost cell cytoplasm
G0044423cellular_componentvirion component
h0006511biological_processubiquitin-dependent protein catabolic process
H0006368biological_processtranscription elongation by RNA polymerase II
H0030891cellular_componentVCB complex
H0070449cellular_componentelongin complex
i0000122biological_processnegative regulation of transcription by RNA polymerase II
i0000209biological_processprotein polyubiquitination
i0001503biological_processossification
i0001649biological_processosteoblast differentiation
i0003677molecular_functionDNA binding
i0003713molecular_functiontranscription coactivator activity
i0005515molecular_functionprotein binding
i0005634cellular_componentnucleus
i0005654cellular_componentnucleoplasm
i0006357biological_processregulation of transcription by RNA polymerase II
i0006366biological_processtranscription by RNA polymerase II
i0016020cellular_componentmembrane
i0016513cellular_componentcore-binding factor complex
i0030098biological_processlymphocyte differentiation
i0030099biological_processmyeloid cell differentiation
i0043371biological_processnegative regulation of CD4-positive, alpha-beta T cell differentiation
i0043378biological_processpositive regulation of CD8-positive, alpha-beta T cell differentiation
i0043565molecular_functionsequence-specific DNA binding
i0045944biological_processpositive regulation of transcription by RNA polymerase II
i0048469biological_processcell maturation
i0060216biological_processdefinitive hemopoiesis
I0006511biological_processubiquitin-dependent protein catabolic process
I0031625molecular_functionubiquitin protein ligase binding
j0003723molecular_functionRNA binding
j0005515molecular_functionprotein binding
j0016020cellular_componentmembrane
j0019058biological_processviral life cycle
j0020002cellular_componenthost cell plasma membrane
j0030430cellular_componenthost cell cytoplasm
j0044423cellular_componentvirion component
J0006368biological_processtranscription elongation by RNA polymerase II
J0030891cellular_componentVCB complex
J0070449cellular_componentelongin complex
k0000122biological_processnegative regulation of transcription by RNA polymerase II
k0000209biological_processprotein polyubiquitination
k0001503biological_processossification
k0001649biological_processosteoblast differentiation
k0003677molecular_functionDNA binding
k0003713molecular_functiontranscription coactivator activity
k0005515molecular_functionprotein binding
k0005634cellular_componentnucleus
k0005654cellular_componentnucleoplasm
k0006357biological_processregulation of transcription by RNA polymerase II
k0006366biological_processtranscription by RNA polymerase II
k0016020cellular_componentmembrane
k0016513cellular_componentcore-binding factor complex
k0030098biological_processlymphocyte differentiation
k0030099biological_processmyeloid cell differentiation
k0043371biological_processnegative regulation of CD4-positive, alpha-beta T cell differentiation
k0043378biological_processpositive regulation of CD8-positive, alpha-beta T cell differentiation
k0043565molecular_functionsequence-specific DNA binding
k0045944biological_processpositive regulation of transcription by RNA polymerase II
k0048469biological_processcell maturation
k0060216biological_processdefinitive hemopoiesis
K0006511biological_processubiquitin-dependent protein catabolic process
l0006511biological_processubiquitin-dependent protein catabolic process
l0031625molecular_functionubiquitin protein ligase binding
L0000122biological_processnegative regulation of transcription by RNA polymerase II
L0000209biological_processprotein polyubiquitination
L0001503biological_processossification
L0001649biological_processosteoblast differentiation
L0003677molecular_functionDNA binding
L0003713molecular_functiontranscription coactivator activity
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0006357biological_processregulation of transcription by RNA polymerase II
L0006366biological_processtranscription by RNA polymerase II
L0016020cellular_componentmembrane
L0016513cellular_componentcore-binding factor complex
L0030098biological_processlymphocyte differentiation
L0030099biological_processmyeloid cell differentiation
L0043371biological_processnegative regulation of CD4-positive, alpha-beta T cell differentiation
L0043378biological_processpositive regulation of CD8-positive, alpha-beta T cell differentiation
L0043565molecular_functionsequence-specific DNA binding
L0045944biological_processpositive regulation of transcription by RNA polymerase II
L0048469biological_processcell maturation
L0060216biological_processdefinitive hemopoiesis
m0006368biological_processtranscription elongation by RNA polymerase II
m0030891cellular_componentVCB complex
m0070449cellular_componentelongin complex
M0003723molecular_functionRNA binding
M0005515molecular_functionprotein binding
M0016020cellular_componentmembrane
M0019058biological_processviral life cycle
M0020002cellular_componenthost cell plasma membrane
M0030430cellular_componenthost cell cytoplasm
M0044423cellular_componentvirion component
n0006511biological_processubiquitin-dependent protein catabolic process
N0000122biological_processnegative regulation of transcription by RNA polymerase II
N0000209biological_processprotein polyubiquitination
N0001503biological_processossification
N0001649biological_processosteoblast differentiation
N0003677molecular_functionDNA binding
N0003713molecular_functiontranscription coactivator activity
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005654cellular_componentnucleoplasm
N0006357biological_processregulation of transcription by RNA polymerase II
N0006366biological_processtranscription by RNA polymerase II
N0016020cellular_componentmembrane
N0016513cellular_componentcore-binding factor complex
N0030098biological_processlymphocyte differentiation
N0030099biological_processmyeloid cell differentiation
N0043371biological_processnegative regulation of CD4-positive, alpha-beta T cell differentiation
N0043378biological_processpositive regulation of CD8-positive, alpha-beta T cell differentiation
N0043565molecular_functionsequence-specific DNA binding
N0045944biological_processpositive regulation of transcription by RNA polymerase II
N0048469biological_processcell maturation
N0060216biological_processdefinitive hemopoiesis
o0000122biological_processnegative regulation of transcription by RNA polymerase II
o0000209biological_processprotein polyubiquitination
o0001503biological_processossification
o0001649biological_processosteoblast differentiation
o0003677molecular_functionDNA binding
o0003713molecular_functiontranscription coactivator activity
o0005515molecular_functionprotein binding
o0005634cellular_componentnucleus
o0005654cellular_componentnucleoplasm
o0006357biological_processregulation of transcription by RNA polymerase II
o0006366biological_processtranscription by RNA polymerase II
o0016020cellular_componentmembrane
o0016513cellular_componentcore-binding factor complex
o0030098biological_processlymphocyte differentiation
o0030099biological_processmyeloid cell differentiation
o0043371biological_processnegative regulation of CD4-positive, alpha-beta T cell differentiation
o0043378biological_processpositive regulation of CD8-positive, alpha-beta T cell differentiation
o0043565molecular_functionsequence-specific DNA binding
o0045944biological_processpositive regulation of transcription by RNA polymerase II
o0048469biological_processcell maturation
o0060216biological_processdefinitive hemopoiesis
O0006511biological_processubiquitin-dependent protein catabolic process
O0031625molecular_functionubiquitin protein ligase binding
p0003723molecular_functionRNA binding
p0005515molecular_functionprotein binding
p0016020cellular_componentmembrane
p0019058biological_processviral life cycle
p0020002cellular_componenthost cell plasma membrane
p0030430cellular_componenthost cell cytoplasm
p0044423cellular_componentvirion component
P0006368biological_processtranscription elongation by RNA polymerase II
P0030891cellular_componentVCB complex
P0070449cellular_componentelongin complex
q0003723molecular_functionRNA binding
q0005515molecular_functionprotein binding
q0016020cellular_componentmembrane
q0019058biological_processviral life cycle
q0020002cellular_componenthost cell plasma membrane
q0030430cellular_componenthost cell cytoplasm
q0044423cellular_componentvirion component
Q0006511biological_processubiquitin-dependent protein catabolic process
r0006511biological_processubiquitin-dependent protein catabolic process
r0031625molecular_functionubiquitin protein ligase binding
R0000122biological_processnegative regulation of transcription by RNA polymerase II
R0000209biological_processprotein polyubiquitination
R0001503biological_processossification
R0001649biological_processosteoblast differentiation
R0003677molecular_functionDNA binding
R0003713molecular_functiontranscription coactivator activity
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0005654cellular_componentnucleoplasm
R0006357biological_processregulation of transcription by RNA polymerase II
R0006366biological_processtranscription by RNA polymerase II
R0016020cellular_componentmembrane
R0016513cellular_componentcore-binding factor complex
R0030098biological_processlymphocyte differentiation
R0030099biological_processmyeloid cell differentiation
R0043371biological_processnegative regulation of CD4-positive, alpha-beta T cell differentiation
R0043378biological_processpositive regulation of CD8-positive, alpha-beta T cell differentiation
R0043565molecular_functionsequence-specific DNA binding
R0045944biological_processpositive regulation of transcription by RNA polymerase II
R0048469biological_processcell maturation
R0060216biological_processdefinitive hemopoiesis
s0006368biological_processtranscription elongation by RNA polymerase II
s0030891cellular_componentVCB complex
s0070449cellular_componentelongin complex
S0003723molecular_functionRNA binding
S0005515molecular_functionprotein binding
S0016020cellular_componentmembrane
S0019058biological_processviral life cycle
S0020002cellular_componenthost cell plasma membrane
S0030430cellular_componenthost cell cytoplasm
S0044423cellular_componentvirion component
t0006511biological_processubiquitin-dependent protein catabolic process
T0006511biological_processubiquitin-dependent protein catabolic process
u0000122biological_processnegative regulation of transcription by RNA polymerase II
u0000209biological_processprotein polyubiquitination
u0001503biological_processossification
u0001649biological_processosteoblast differentiation
u0003677molecular_functionDNA binding
u0003713molecular_functiontranscription coactivator activity
u0005515molecular_functionprotein binding
u0005634cellular_componentnucleus
u0005654cellular_componentnucleoplasm
u0006357biological_processregulation of transcription by RNA polymerase II
u0006366biological_processtranscription by RNA polymerase II
u0016020cellular_componentmembrane
u0016513cellular_componentcore-binding factor complex
u0030098biological_processlymphocyte differentiation
u0030099biological_processmyeloid cell differentiation
u0043371biological_processnegative regulation of CD4-positive, alpha-beta T cell differentiation
u0043378biological_processpositive regulation of CD8-positive, alpha-beta T cell differentiation
u0043565molecular_functionsequence-specific DNA binding
u0045944biological_processpositive regulation of transcription by RNA polymerase II
u0048469biological_processcell maturation
u0060216biological_processdefinitive hemopoiesis
U0006511biological_processubiquitin-dependent protein catabolic process
U0031625molecular_functionubiquitin protein ligase binding
v0003723molecular_functionRNA binding
v0005515molecular_functionprotein binding
v0016020cellular_componentmembrane
v0019058biological_processviral life cycle
v0020002cellular_componenthost cell plasma membrane
v0030430cellular_componenthost cell cytoplasm
v0044423cellular_componentvirion component
V0006511biological_processubiquitin-dependent protein catabolic process
V0031625molecular_functionubiquitin protein ligase binding
w0006511biological_processubiquitin-dependent protein catabolic process
w0031625molecular_functionubiquitin protein ligase binding
W0006368biological_processtranscription elongation by RNA polymerase II
W0030891cellular_componentVCB complex
W0070449cellular_componentelongin complex
x0006511biological_processubiquitin-dependent protein catabolic process
x0031625molecular_functionubiquitin protein ligase binding
X0006368biological_processtranscription elongation by RNA polymerase II
X0030891cellular_componentVCB complex
X0070449cellular_componentelongin complex
y0006368biological_processtranscription elongation by RNA polymerase II
y0030891cellular_componentVCB complex
y0070449cellular_componentelongin complex
Y0006511biological_processubiquitin-dependent protein catabolic process
z0006511biological_processubiquitin-dependent protein catabolic process
Z0006511biological_processubiquitin-dependent protein catabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN b 201
ChainResidue
bHIS108
bCYS114
bCYS133
bGLU134
bHIS139

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN G 201
ChainResidue
GHIS139
GHIS108
GCYS114
GCYS133
GGLU134

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN M 201
ChainResidue
MHIS108
MCYS114
MCYS133
MHIS139

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN S 201
ChainResidue
SHIS108
SCYS114
SCYS133
SGLU134
SHIS139

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN d 201
ChainResidue
dHIS108
dCYS114
dCYS133
dHIS139

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN j 201
ChainResidue
jHIS108
jCYS114
jCYS133
jGLU134
jHIS139

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN p 201
ChainResidue
pHIS108
pCYS114
pCYS133
pHIS139

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN v 201
ChainResidue
vHIS108
vCYS114
vCYS133
vHIS139

site_idAC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN 1 201
ChainResidue
1HIS108
1CYS114
1CYS133
1GLU134
1HIS139

site_idBC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN 7 201
ChainResidue
7HIS108
7CYS114
7CYS133
7GLU134
7HIS139

site_idBC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN q 201
ChainResidue
qHIS108
qCYS114
qCYS133
qHIS139

site_idBC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN 2 201
ChainResidue
2HIS108
2CYS114
2CYS133
2HIS139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsSITE: Cleavage in virion (by viral protease) => ECO:0000255|HAMAP-Rule:MF_04081
ChainResidueDetails
bLEU150
7LEU150
qLEU150
2LEU151
GLEU150
MLEU150
SLEU151
dLEU150
jLEU150
pLEU150
vLEU151
1LEU151

site_idSWS_FT_FI2
Number of Residues12
DetailsMOD_RES: Phosphothreonine; by host MAP4K1 => ECO:0000255|HAMAP-Rule:MF_04081
ChainResidueDetails
bTHR96
7THR96
qTHR96
2THR96
GTHR96
MTHR96
STHR96
dTHR96
jTHR96
pTHR96
vTHR96
1THR96

site_idSWS_FT_FI3
Number of Residues12
DetailsMOD_RES: Phosphoserine; by host => ECO:0000255|HAMAP-Rule:MF_04081
ChainResidueDetails
bSER144
7SER144
qSER144
2SER145
GSER144
MSER144
SSER145
dSER144
jSER144
pSER144
vSER145
1SER145

site_idSWS_FT_FI4
Number of Residues12
DetailsMOD_RES: Phosphoserine; by host MAP4K1 => ECO:0000255|HAMAP-Rule:MF_04081
ChainResidueDetails
bSER165
7SER165
qSER165
2SER166
GSER165
MSER165
SSER166
dSER165
jSER165
pSER165
vSER166
1SER166

219140

PDB entries from 2024-05-01

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