4N39
Crystal structure of human O-GlcNAc transferase bound to a peptide from HCF-1 pro-repeat 2 (11-26)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE UDP A 1201 |
| Chain | Residue |
| A | PRO559 |
| A | HIS920 |
| A | THR921 |
| A | THR922 |
| A | ASP925 |
| A | HOH1320 |
| A | HOH1344 |
| A | HOH1359 |
| A | HOH1424 |
| A | HOH1427 |
| A | HOH1518 |
| A | GLN839 |
| A | LYS842 |
| A | LEU866 |
| A | VAL895 |
| A | ALA896 |
| A | LYS898 |
| A | HIS901 |
| A | ARG904 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:21240259, ECO:0000305|PubMed:26678539 |
| Chain | Residue | Details |
| A | HIS498 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23103939, ECO:0007744|PDB:4GYW |
| Chain | Residue | Details |
| A | GLN839 | |
| A | LYS842 | |
| A | ALA896 | |
| A | HIS901 | |
| A | HIS920 | |
| A | ASP925 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by AMPK => ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:37541260 |
| Chain | Residue | Details |
| A | THR444 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P56558 |
| Chain | Residue | Details |
| A | TYR979 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: O-linked (GlcNAc) serine; by autocatalysis => ECO:0000269|PubMed:27713473 |
| Chain | Residue | Details |
| A | SER389 |
