Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4MXX

Human Src A403T mutant bound to kinase inhibitor bosutinib

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE DB8 A 601
ChainResidue
ALEU273
ATYR340
AMET341
ASER342
ALYS343
ALEU393
ATHR403
AALA293
ALYS295
AGLU310
AMET314
AVAL323
AILE336
ATHR338
AGLU339

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE DB8 B 601
ChainResidue
BLEU273
BALA293
BLYS295
BILE336
BTHR338
BGLU339
BTYR340
BMET341
BSER342
BGLY344
BLEU393
BTHR403
BPHE405

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues23
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGCFGEVWmGtwngttr...........VAIK
ChainResidueDetails
ALEU273-LYS295

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLRAANILV
ChainResidueDetails
ATYR382-VAL394

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AASP386
BASP386

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING:
ChainResidueDetails
ALEU273
ALYS295
BLEU273
BLYS295

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by FAK2 => ECO:0000250
ChainResidueDetails
ATYR416
BTYR416

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by CSK => ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:26936507, ECO:0000269|PubMed:7525268, ECO:0000269|PubMed:7929427, ECO:0007744|PubMed:19369195
ChainResidueDetails
ATYR527
BTYR527

219140

PDB entries from 2024-05-01

PDB statisticsPDBj update infoContact PDBjnumon