Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE APC A 301 |
| Chain | Residue |
| A | GLN74 |
| A | THR112 |
| A | HIS115 |
| A | ARG121 |
| A | YH5302 |
| A | MG303 |
| A | MG304 |
| A | HOH417 |
| A | HOH459 |
| A | HOH460 |
| A | ARG82 |
| A | TRP89 |
| A | ARG92 |
| A | ASP95 |
| A | ASP97 |
| A | ILE98 |
| A | ARG110 |
| A | LEU111 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE YH5 A 302 |
| Chain | Residue |
| A | THR42 |
| A | PRO43 |
| A | PRO44 |
| A | LEU45 |
| A | TYR53 |
| A | ASN55 |
| A | TRP89 |
| A | ARG92 |
| A | ARG121 |
| A | PHE123 |
| A | APC301 |
| A | HOH427 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 303 |
| Chain | Residue |
| A | ASP95 |
| A | ASP97 |
| A | APC301 |
| A | MG304 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 304 |
| Chain | Residue |
| A | ASP95 |
| A | ASP97 |
| A | APC301 |
| A | MG303 |
| A | HOH459 |
| A | HOH460 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 305 |
| Chain | Residue |
| A | GLY81 |
| A | ARG92 |
| A | THR93 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 306 |
| Chain | Residue |
| A | LYS119 |
| A | ASP139 |
Functional Information from PROSITE/UniProt
| site_id | PS00794 |
| Number of Residues | 12 |
| Details | HPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. RwGPRtlDLDIM |
| Chain | Residue | Details |
| A | ARG88-MET99 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 151 |
| Chain | Residue | Details |
| A | ARG82 | electrostatic stabiliser, hydrogen bond donor |
| A | ARG92 | electrostatic stabiliser, hydrogen bond donor |
| A | ASP95 | metal ligand |
| A | ASP97 | metal ligand |
