4LW4

Structural changes during cysteine desulfurase CsdA and sulfur-acceptor CsdE interactions provide insight into the trans-persulfuration

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000096	biological_process	sulfur amino acid metabolic process
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0006534	biological_process	cysteine metabolic process
A	0008826	molecular_function	cysteine sulfinate desulfinase activity
A	0009000	molecular_function	selenocysteine lyase activity
A	0016226	biological_process	iron-sulfur cluster assembly
A	0016261	biological_process	selenocysteine catabolic process
A	0016740	molecular_function	transferase activity
A	0016783	molecular_function	sulfurtransferase activity
A	0016787	molecular_function	hydrolase activity
A	0016829	molecular_function	lyase activity
A	0019448	biological_process	L-cysteine catabolic process
A	0030170	molecular_function	pyridoxal phosphate binding
A	0031071	molecular_function	cysteine desulfurase activity
A	0072348	biological_process	sulfur compound transport
A	1990221	cellular_component	L-cysteine desulfurase complex
B	0000096	biological_process	sulfur amino acid metabolic process
B	0003824	molecular_function	catalytic activity
B	0005515	molecular_function	protein binding
B	0006534	biological_process	cysteine metabolic process
B	0008826	molecular_function	cysteine sulfinate desulfinase activity
B	0009000	molecular_function	selenocysteine lyase activity
B	0016226	biological_process	iron-sulfur cluster assembly
B	0016261	biological_process	selenocysteine catabolic process
B	0016740	molecular_function	transferase activity
B	0016783	molecular_function	sulfurtransferase activity
B	0016787	molecular_function	hydrolase activity
B	0016829	molecular_function	lyase activity
B	0019448	biological_process	L-cysteine catabolic process
B	0030170	molecular_function	pyridoxal phosphate binding
B	0031071	molecular_function	cysteine desulfurase activity
B	0072348	biological_process	sulfur compound transport
B	1990221	cellular_component	L-cysteine desulfurase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PLP A 500

Chain	Residue
A	THR90
A	LYS222
A	HOH602
A	HOH640
A	HOH781
B	THR273
A	THR91
A	HIS119
A	ASN171
A	ASP196
A	ALA198
A	GLN199
A	SER219
A	HIS221

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site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE PLP B 500

Chain	Residue
A	GLY272
A	THR273
B	THR90
B	THR91
B	HIS119
B	ALA121
B	ASN171
B	ASP196
B	ALA198
B	GLN199
B	SER219
B	HIS221
B	LYS222
B	HOH640
B	HOH654
B	HOH757

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Functional Information from PROSITE/UniProt

site_id	PS00595
Number of Residues	20
Details	AA_TRANSFER_CLASS_5 Aminotransferases class-V pyridoxal-phosphate attachment site. IDFYafSGHKlygpt.GiGvL

Chain	Residue	Details
A	ILE213-LEU232

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Cysteine persulfide intermediate => ECO:0000305|PubMed:10739946

Chain	Residue	Details
A	CYS358
B	CYS358

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000250

Chain	Residue	Details
A	LYS222
B	LYS222

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