4LKP
Crystal Structure of Apo Human Epidermal Fatty Acid Binding Protein (FABP5)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001972 | molecular_function | retinoic acid binding |
| A | 0005324 | molecular_function | long-chain fatty acid transmembrane transporter activity |
| A | 0005504 | molecular_function | fatty acid binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006656 | biological_process | phosphatidylcholine biosynthetic process |
| A | 0006869 | biological_process | lipid transport |
| A | 0008289 | molecular_function | lipid binding |
| A | 0008544 | biological_process | epidermis development |
| A | 0010829 | biological_process | negative regulation of glucose transmembrane transport |
| A | 0014069 | cellular_component | postsynaptic density |
| A | 0015908 | biological_process | fatty acid transport |
| A | 0015909 | biological_process | long-chain fatty acid transport |
| A | 0030667 | cellular_component | secretory granule membrane |
| A | 0031392 | biological_process | regulation of prostaglandin biosynthetic process |
| A | 0035360 | biological_process | positive regulation of peroxisome proliferator activated receptor signaling pathway |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0042593 | biological_process | glucose homeostasis |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045202 | cellular_component | synapse |
| A | 0051930 | biological_process | regulation of sensory perception of pain |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0099178 | biological_process | regulation of retrograde trans-synaptic signaling by endocanabinoid |
| A | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
| A | 1990379 | biological_process | lipid transport across blood-brain barrier |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 201 |
| Chain | Residue |
| A | LYS110 |
| A | LYS112 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS A 202 |
| Chain | Residue |
| A | LYS24 |
| A | THR46 |
| A | ASP48 |
| A | LEU52 |
| A | THR53 |
| A | HOH316 |
| A | HOH356 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS A 203 |
| Chain | Residue |
| A | LYS72 |
| A | PHE73 |
| A | GLU74 |
| A | THR108 |
| A | GLU119 |
| A | VAL121 |
| A | HOH346 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NH4 A 204 |
| Chain | Residue |
| A | LYS17 |
| A | GLY18 |
| A | SO4205 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 205 |
| Chain | Residue |
| A | SER16 |
| A | LYS17 |
| A | GLY18 |
| A | PHE19 |
| A | ASP20 |
| A | NH4204 |
| A | HOH340 |
| A | HOH375 |
Functional Information from PROSITE/UniProt
| site_id | PS00214 |
| Number of Residues | 18 |
| Details | FABP Cytosolic fatty-acid binding proteins signature. GRWrLvdSkGFDeYMKEL |
| Chain | Residue | Details |
| A | GLY9-LEU26 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24531463, ECO:0007744|PDB:4AZR |
| Chain | Residue | Details |
| A | TYR131 | |
| A | CYS43 | |
| A | ARG109 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24692551, ECO:0007744|PDB:4LKT |
| Chain | Residue | Details |
| A | ARG129 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:12665801, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712 |
| Chain | Residue | Details |
| A | ALA2 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS17 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455 |
| Chain | Residue | Details |
| A | TYR131 |
