4K7O

HUMAN PEROXIREDOXIN 5 with a fragment

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0016491	molecular_function	oxidoreductase activity
A	0034599	biological_process	cellular response to oxidative stress
B	0008379	molecular_function	thioredoxin peroxidase activity
B	0016491	molecular_function	oxidoreductase activity
B	0034599	biological_process	cellular response to oxidative stress
C	0008379	molecular_function	thioredoxin peroxidase activity
C	0016491	molecular_function	oxidoreductase activity
C	0034599	biological_process	cellular response to oxidative stress

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE EKZ A 201

Chain	Residue
A	PRO40
C	LYS63
C	ALA64
C	LYS65
C	GLY66
A	THR44
A	PRO45
A	GLY46
A	CYS47
A	LEU116
A	PHE120
A	ARG127
A	THR147

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS A 202

Chain	Residue
A	LYS63
A	VAL69
A	VAL70
A	GLY92
A	LYS93
A	ARG95
A	HOH2124

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE EKZ B 201

Chain	Residue
A	ALA64
A	GLY66
B	PRO40
B	THR44
B	PRO45
B	GLY46
B	CYS47
B	LEU116
B	PHE120
B	ARG127
B	THR147
B	HOH364

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS B 202

Chain	Residue
B	VAL69
B	VAL70
B	GLY92
B	LYS93
B	VAL94
B	ARG95
B	HOH392

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS B 203

Chain	Residue
A	LYS32
A	GLN68
A	HOH2044
B	LEU112
B	ASP113

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS C 201

Chain	Residue
C	LYS63
C	VAL69
C	VAL70
C	GLY92
C	LYS93
C	ARG95
C	HOH354

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EKZ C 202

Chain	Residue
C	THR44
C	PRO45
C	GLY46
C	CYS47
C	LEU116
C	ARG127
C	ASP145

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Cysteine sulfenic acid (-SOH) intermediate => ECO:0000305|PubMed:10751410, ECO:0000305|PubMed:20643143

Chain	Residue	Details
A	CYS47
B	CYS47
C	CYS47

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P99029

Chain	Residue	Details
A	LYS22
B	LYS22
C	LYS22

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P99029

Chain	Residue	Details
A	LYS30
B	LYS30
C	LYS30

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P99029

Chain	Residue	Details
A	LYS63
B	LYS63
C	LYS63

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9R063

Chain	Residue	Details
A	SER118
B	SER118
C	SER118

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P99029

Chain	Residue	Details
A	SER129
B	SER129
C	SER129

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:31740833

Chain	Residue	Details
A	CYS47
B	CYS47
C	CYS47

---