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4J1R

Crystal Structure of GSK3b in complex with inhibitor 15R

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001837biological_processepithelial to mesenchymal transition
A0001954biological_processpositive regulation of cell-matrix adhesion
A0002020molecular_functionprotease binding
A0002039molecular_functionp53 binding
A0003170biological_processheart valve development
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005977biological_processglycogen metabolic process
A0006468biological_processprotein phosphorylation
A0006983biological_processER overload response
A0007212biological_processdopamine receptor signaling pathway
A0007399biological_processnervous system development
A0007623biological_processcircadian rhythm
A0008013molecular_functionbeta-catenin binding
A0008286biological_processinsulin receptor signaling pathway
A0009968biological_processnegative regulation of signal transduction
A0010508biological_processpositive regulation of autophagy
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010822biological_processobsolete positive regulation of mitochondrion organization
A0010975biological_processregulation of neuron projection development
A0010977biological_processnegative regulation of neuron projection development
A0016020cellular_componentmembrane
A0016055biological_processWnt signaling pathway
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016740molecular_functiontransferase activity
A0018105biological_processpeptidyl-serine phosphorylation
A0018107biological_processpeptidyl-threonine phosphorylation
A0019082biological_processviral protein processing
A0019901molecular_functionprotein kinase binding
A0021766biological_processhippocampus development
A0030010biological_processestablishment of cell polarity
A0030011biological_processmaintenance of cell polarity
A0030154biological_processcell differentiation
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030516biological_processregulation of axon extension
A0030877cellular_componentbeta-catenin destruction complex
A0031175biological_processneuron projection development
A0031333biological_processnegative regulation of protein-containing complex assembly
A0031334biological_processpositive regulation of protein-containing complex assembly
A0031398biological_processpositive regulation of protein ubiquitination
A0031625molecular_functionubiquitin protein ligase binding
A0032007biological_processnegative regulation of TOR signaling
A0032092biological_processpositive regulation of protein binding
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0032515biological_processnegative regulation of phosphoprotein phosphatase activity
A0032886biological_processregulation of microtubule-based process
A0034236molecular_functionprotein kinase A catalytic subunit binding
A0034452molecular_functiondynactin binding
A0035556biological_processintracellular signal transduction
A0036016biological_processcellular response to interleukin-3
A0042752biological_processregulation of circadian rhythm
A0043066biological_processnegative regulation of apoptotic process
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0043525biological_processpositive regulation of neuron apoptotic process
A0043547biological_processpositive regulation of GTPase activity
A0045597biological_processpositive regulation of cell differentiation
A0045668biological_processnegative regulation of osteoblast differentiation
A0045719biological_processnegative regulation of glycogen biosynthetic process
A0045724biological_processpositive regulation of cilium assembly
A0045732biological_processpositive regulation of protein catabolic process
A0046627biological_processnegative regulation of insulin receptor signaling pathway
A0046777biological_processprotein autophosphorylation
A0046825biological_processregulation of protein export from nucleus
A0046827biological_processpositive regulation of protein export from nucleus
A0048156molecular_functiontau protein binding
A0048511biological_processrhythmic process
A0048814biological_processregulation of dendrite morphogenesis
A0050321molecular_functiontau-protein kinase activity
A0050770biological_processregulation of axonogenesis
A0051059molecular_functionNF-kappaB binding
A0051093biological_processnegative regulation of developmental process
A0051128biological_processregulation of cellular component organization
A0060070biological_processcanonical Wnt signaling pathway
A0060079biological_processexcitatory postsynaptic potential
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0070507biological_processregulation of microtubule cytoskeleton organization
A0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
A0071109biological_processsuperior temporal gyrus development
A0071300biological_processcellular response to retinoic acid
A0090090biological_processnegative regulation of canonical Wnt signaling pathway
A0097191biological_processextrinsic apoptotic signaling pathway
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099171biological_processpresynaptic modulation of chemical synaptic transmission
A0106027biological_processneuron projection organization
A0106310molecular_functionprotein serine kinase activity
A0150101biological_processregulation of microtubule anchoring at centrosome
A1900034biological_processregulation of cellular response to heat
A1900181biological_processnegative regulation of protein localization to nucleus
A1900271biological_processregulation of long-term synaptic potentiation
A1901030biological_processpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
A1901984biological_processnegative regulation of protein acetylation
A1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
A1903566biological_processpositive regulation of protein localization to cilium
A1904339biological_processnegative regulation of dopaminergic neuron differentiation
A1904646biological_processcellular response to amyloid-beta
A1904781biological_processpositive regulation of protein localization to centrosome
A1904886biological_processbeta-catenin destruction complex disassembly
A1990909cellular_componentWnt signalosome
A2000077biological_processnegative regulation of type B pancreatic cell development
A2000466biological_processnegative regulation of glycogen (starch) synthase activity
A2000740biological_processnegative regulation of mesenchymal stem cell differentiation
B0000166molecular_functionnucleotide binding
B0001837biological_processepithelial to mesenchymal transition
B0001954biological_processpositive regulation of cell-matrix adhesion
B0002020molecular_functionprotease binding
B0002039molecular_functionp53 binding
B0003170biological_processheart valve development
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005977biological_processglycogen metabolic process
B0006468biological_processprotein phosphorylation
B0006983biological_processER overload response
B0007212biological_processdopamine receptor signaling pathway
B0007399biological_processnervous system development
B0007623biological_processcircadian rhythm
B0008013molecular_functionbeta-catenin binding
B0008286biological_processinsulin receptor signaling pathway
B0009968biological_processnegative regulation of signal transduction
B0010508biological_processpositive regulation of autophagy
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0010822biological_processobsolete positive regulation of mitochondrion organization
B0010975biological_processregulation of neuron projection development
B0010977biological_processnegative regulation of neuron projection development
B0016020cellular_componentmembrane
B0016055biological_processWnt signaling pathway
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0016740molecular_functiontransferase activity
B0018105biological_processpeptidyl-serine phosphorylation
B0018107biological_processpeptidyl-threonine phosphorylation
B0019082biological_processviral protein processing
B0019901molecular_functionprotein kinase binding
B0021766biological_processhippocampus development
B0030010biological_processestablishment of cell polarity
B0030011biological_processmaintenance of cell polarity
B0030154biological_processcell differentiation
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0030516biological_processregulation of axon extension
B0030877cellular_componentbeta-catenin destruction complex
B0031175biological_processneuron projection development
B0031333biological_processnegative regulation of protein-containing complex assembly
B0031334biological_processpositive regulation of protein-containing complex assembly
B0031398biological_processpositive regulation of protein ubiquitination
B0031625molecular_functionubiquitin protein ligase binding
B0032007biological_processnegative regulation of TOR signaling
B0032092biological_processpositive regulation of protein binding
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032515biological_processnegative regulation of phosphoprotein phosphatase activity
B0032886biological_processregulation of microtubule-based process
B0034236molecular_functionprotein kinase A catalytic subunit binding
B0034452molecular_functiondynactin binding
B0035556biological_processintracellular signal transduction
B0036016biological_processcellular response to interleukin-3
B0042752biological_processregulation of circadian rhythm
B0043066biological_processnegative regulation of apoptotic process
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043525biological_processpositive regulation of neuron apoptotic process
B0043547biological_processpositive regulation of GTPase activity
B0045597biological_processpositive regulation of cell differentiation
B0045668biological_processnegative regulation of osteoblast differentiation
B0045719biological_processnegative regulation of glycogen biosynthetic process
B0045724biological_processpositive regulation of cilium assembly
B0045732biological_processpositive regulation of protein catabolic process
B0046627biological_processnegative regulation of insulin receptor signaling pathway
B0046777biological_processprotein autophosphorylation
B0046825biological_processregulation of protein export from nucleus
B0046827biological_processpositive regulation of protein export from nucleus
B0048156molecular_functiontau protein binding
B0048511biological_processrhythmic process
B0048814biological_processregulation of dendrite morphogenesis
B0050321molecular_functiontau-protein kinase activity
B0050770biological_processregulation of axonogenesis
B0051059molecular_functionNF-kappaB binding
B0051093biological_processnegative regulation of developmental process
B0051128biological_processregulation of cellular component organization
B0060070biological_processcanonical Wnt signaling pathway
B0060079biological_processexcitatory postsynaptic potential
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0070507biological_processregulation of microtubule cytoskeleton organization
B0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
B0071109biological_processsuperior temporal gyrus development
B0071300biological_processcellular response to retinoic acid
B0090090biological_processnegative regulation of canonical Wnt signaling pathway
B0097191biological_processextrinsic apoptotic signaling pathway
B0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
B0098793cellular_componentpresynapse
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099171biological_processpresynaptic modulation of chemical synaptic transmission
B0106027biological_processneuron projection organization
B0106310molecular_functionprotein serine kinase activity
B0150101biological_processregulation of microtubule anchoring at centrosome
B1900034biological_processregulation of cellular response to heat
B1900181biological_processnegative regulation of protein localization to nucleus
B1900271biological_processregulation of long-term synaptic potentiation
B1901030biological_processpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
B1901984biological_processnegative regulation of protein acetylation
B1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
B1903566biological_processpositive regulation of protein localization to cilium
B1904339biological_processnegative regulation of dopaminergic neuron differentiation
B1904646biological_processcellular response to amyloid-beta
B1904781biological_processpositive regulation of protein localization to centrosome
B1904886biological_processbeta-catenin destruction complex disassembly
B1990909cellular_componentWnt signalosome
B2000077biological_processnegative regulation of type B pancreatic cell development
B2000466biological_processnegative regulation of glycogen (starch) synthase activity
B2000740biological_processnegative regulation of mesenchymal stem cell differentiation
C0000166molecular_functionnucleotide binding
C0001837biological_processepithelial to mesenchymal transition
C0001954biological_processpositive regulation of cell-matrix adhesion
C0002020molecular_functionprotease binding
C0002039molecular_functionp53 binding
C0003170biological_processheart valve development
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005977biological_processglycogen metabolic process
C0006468biological_processprotein phosphorylation
C0006983biological_processER overload response
C0007212biological_processdopamine receptor signaling pathway
C0007399biological_processnervous system development
C0007623biological_processcircadian rhythm
C0008013molecular_functionbeta-catenin binding
C0008286biological_processinsulin receptor signaling pathway
C0009968biological_processnegative regulation of signal transduction
C0010508biological_processpositive regulation of autophagy
C0010628biological_processpositive regulation of gene expression
C0010629biological_processnegative regulation of gene expression
C0010822biological_processobsolete positive regulation of mitochondrion organization
C0010975biological_processregulation of neuron projection development
C0010977biological_processnegative regulation of neuron projection development
C0016020cellular_componentmembrane
C0016055biological_processWnt signaling pathway
C0016301molecular_functionkinase activity
C0016310biological_processphosphorylation
C0016740molecular_functiontransferase activity
C0018105biological_processpeptidyl-serine phosphorylation
C0018107biological_processpeptidyl-threonine phosphorylation
C0019082biological_processviral protein processing
C0019901molecular_functionprotein kinase binding
C0021766biological_processhippocampus development
C0030010biological_processestablishment of cell polarity
C0030011biological_processmaintenance of cell polarity
C0030154biological_processcell differentiation
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0030516biological_processregulation of axon extension
C0030877cellular_componentbeta-catenin destruction complex
C0031175biological_processneuron projection development
C0031333biological_processnegative regulation of protein-containing complex assembly
C0031334biological_processpositive regulation of protein-containing complex assembly
C0031398biological_processpositive regulation of protein ubiquitination
C0031625molecular_functionubiquitin protein ligase binding
C0032007biological_processnegative regulation of TOR signaling
C0032092biological_processpositive regulation of protein binding
C0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
C0032515biological_processnegative regulation of phosphoprotein phosphatase activity
C0032886biological_processregulation of microtubule-based process
C0034236molecular_functionprotein kinase A catalytic subunit binding
C0034452molecular_functiondynactin binding
C0035556biological_processintracellular signal transduction
C0036016biological_processcellular response to interleukin-3
C0042752biological_processregulation of circadian rhythm
C0043066biological_processnegative regulation of apoptotic process
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0043525biological_processpositive regulation of neuron apoptotic process
C0043547biological_processpositive regulation of GTPase activity
C0045597biological_processpositive regulation of cell differentiation
C0045668biological_processnegative regulation of osteoblast differentiation
C0045719biological_processnegative regulation of glycogen biosynthetic process
C0045724biological_processpositive regulation of cilium assembly
C0045732biological_processpositive regulation of protein catabolic process
C0046627biological_processnegative regulation of insulin receptor signaling pathway
C0046777biological_processprotein autophosphorylation
C0046825biological_processregulation of protein export from nucleus
C0046827biological_processpositive regulation of protein export from nucleus
C0048156molecular_functiontau protein binding
C0048511biological_processrhythmic process
C0048814biological_processregulation of dendrite morphogenesis
C0050321molecular_functiontau-protein kinase activity
C0050770biological_processregulation of axonogenesis
C0051059molecular_functionNF-kappaB binding
C0051093biological_processnegative regulation of developmental process
C0051128biological_processregulation of cellular component organization
C0060070biological_processcanonical Wnt signaling pathway
C0060079biological_processexcitatory postsynaptic potential
C0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
C0070507biological_processregulation of microtubule cytoskeleton organization
C0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
C0071109biological_processsuperior temporal gyrus development
C0071300biological_processcellular response to retinoic acid
C0090090biological_processnegative regulation of canonical Wnt signaling pathway
C0097191biological_processextrinsic apoptotic signaling pathway
C0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
C0098793cellular_componentpresynapse
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0099171biological_processpresynaptic modulation of chemical synaptic transmission
C0106027biological_processneuron projection organization
C0106310molecular_functionprotein serine kinase activity
C0150101biological_processregulation of microtubule anchoring at centrosome
C1900034biological_processregulation of cellular response to heat
C1900181biological_processnegative regulation of protein localization to nucleus
C1900271biological_processregulation of long-term synaptic potentiation
C1901030biological_processpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
C1901984biological_processnegative regulation of protein acetylation
C1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
C1903566biological_processpositive regulation of protein localization to cilium
C1904339biological_processnegative regulation of dopaminergic neuron differentiation
C1904646biological_processcellular response to amyloid-beta
C1904781biological_processpositive regulation of protein localization to centrosome
C1904886biological_processbeta-catenin destruction complex disassembly
C1990909cellular_componentWnt signalosome
C2000077biological_processnegative regulation of type B pancreatic cell development
C2000466biological_processnegative regulation of glycogen (starch) synthase activity
C2000740biological_processnegative regulation of mesenchymal stem cell differentiation
D0000166molecular_functionnucleotide binding
D0001837biological_processepithelial to mesenchymal transition
D0001954biological_processpositive regulation of cell-matrix adhesion
D0002020molecular_functionprotease binding
D0002039molecular_functionp53 binding
D0003170biological_processheart valve development
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005977biological_processglycogen metabolic process
D0006468biological_processprotein phosphorylation
D0006983biological_processER overload response
D0007212biological_processdopamine receptor signaling pathway
D0007399biological_processnervous system development
D0007623biological_processcircadian rhythm
D0008013molecular_functionbeta-catenin binding
D0008286biological_processinsulin receptor signaling pathway
D0009968biological_processnegative regulation of signal transduction
D0010508biological_processpositive regulation of autophagy
D0010628biological_processpositive regulation of gene expression
D0010629biological_processnegative regulation of gene expression
D0010822biological_processobsolete positive regulation of mitochondrion organization
D0010975biological_processregulation of neuron projection development
D0010977biological_processnegative regulation of neuron projection development
D0016020cellular_componentmembrane
D0016055biological_processWnt signaling pathway
D0016301molecular_functionkinase activity
D0016310biological_processphosphorylation
D0016740molecular_functiontransferase activity
D0018105biological_processpeptidyl-serine phosphorylation
D0018107biological_processpeptidyl-threonine phosphorylation
D0019082biological_processviral protein processing
D0019901molecular_functionprotein kinase binding
D0021766biological_processhippocampus development
D0030010biological_processestablishment of cell polarity
D0030011biological_processmaintenance of cell polarity
D0030154biological_processcell differentiation
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0030516biological_processregulation of axon extension
D0030877cellular_componentbeta-catenin destruction complex
D0031175biological_processneuron projection development
D0031333biological_processnegative regulation of protein-containing complex assembly
D0031334biological_processpositive regulation of protein-containing complex assembly
D0031398biological_processpositive regulation of protein ubiquitination
D0031625molecular_functionubiquitin protein ligase binding
D0032007biological_processnegative regulation of TOR signaling
D0032092biological_processpositive regulation of protein binding
D0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
D0032515biological_processnegative regulation of phosphoprotein phosphatase activity
D0032886biological_processregulation of microtubule-based process
D0034236molecular_functionprotein kinase A catalytic subunit binding
D0034452molecular_functiondynactin binding
D0035556biological_processintracellular signal transduction
D0036016biological_processcellular response to interleukin-3
D0042752biological_processregulation of circadian rhythm
D0043066biological_processnegative regulation of apoptotic process
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0043525biological_processpositive regulation of neuron apoptotic process
D0043547biological_processpositive regulation of GTPase activity
D0045597biological_processpositive regulation of cell differentiation
D0045668biological_processnegative regulation of osteoblast differentiation
D0045719biological_processnegative regulation of glycogen biosynthetic process
D0045724biological_processpositive regulation of cilium assembly
D0045732biological_processpositive regulation of protein catabolic process
D0046627biological_processnegative regulation of insulin receptor signaling pathway
D0046777biological_processprotein autophosphorylation
D0046825biological_processregulation of protein export from nucleus
D0046827biological_processpositive regulation of protein export from nucleus
D0048156molecular_functiontau protein binding
D0048511biological_processrhythmic process
D0048814biological_processregulation of dendrite morphogenesis
D0050321molecular_functiontau-protein kinase activity
D0050770biological_processregulation of axonogenesis
D0051059molecular_functionNF-kappaB binding
D0051093biological_processnegative regulation of developmental process
D0051128biological_processregulation of cellular component organization
D0060070biological_processcanonical Wnt signaling pathway
D0060079biological_processexcitatory postsynaptic potential
D0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
D0070507biological_processregulation of microtubule cytoskeleton organization
D0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
D0071109biological_processsuperior temporal gyrus development
D0071300biological_processcellular response to retinoic acid
D0090090biological_processnegative regulation of canonical Wnt signaling pathway
D0097191biological_processextrinsic apoptotic signaling pathway
D0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
D0098793cellular_componentpresynapse
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0099171biological_processpresynaptic modulation of chemical synaptic transmission
D0106027biological_processneuron projection organization
D0106310molecular_functionprotein serine kinase activity
D0150101biological_processregulation of microtubule anchoring at centrosome
D1900034biological_processregulation of cellular response to heat
D1900181biological_processnegative regulation of protein localization to nucleus
D1900271biological_processregulation of long-term synaptic potentiation
D1901030biological_processpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
D1901984biological_processnegative regulation of protein acetylation
D1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
D1903566biological_processpositive regulation of protein localization to cilium
D1904339biological_processnegative regulation of dopaminergic neuron differentiation
D1904646biological_processcellular response to amyloid-beta
D1904781biological_processpositive regulation of protein localization to centrosome
D1904886biological_processbeta-catenin destruction complex disassembly
D1990909cellular_componentWnt signalosome
D2000077biological_processnegative regulation of type B pancreatic cell development
D2000466biological_processnegative regulation of glycogen (starch) synthase activity
D2000740biological_processnegative regulation of mesenchymal stem cell differentiation
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PO4 A 501
ChainResidue
AARG96
AARG180
ALYS205
APRO212
AVAL214

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE I5R A 502
ChainResidue
AASP133
ATYR134
AVAL135
ACYS199
AHOH616
AHOH619
AGLY63
AVAL70
AVAL110
ALEU132

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE K A 503
ChainResidue
ATHR43
BPRO351

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PO4 B 501
ChainResidue
BARG96
BARG180
BLYS205
BASN213
BVAL214

site_idAC5
Number of Residues9
DetailsBINDING SITE FOR RESIDUE I5R B 502
ChainResidue
BPHE67
BVAL70
BVAL110
BLEU132
BASP133
BTYR134
BVAL135
BCYS199
BASP200

site_idAC6
Number of Residues1
DetailsBINDING SITE FOR RESIDUE K B 503
ChainResidue
BTHR43

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PO4 C 501
ChainResidue
CARG96
CARG180
CLYS205
CASN213
CVAL214

site_idAC8
Number of Residues11
DetailsBINDING SITE FOR RESIDUE I5R C 502
ChainResidue
CGLY63
CVAL70
CVAL110
CLEU132
CASP133
CTYR134
CVAL135
CPRO136
CLEU188
CHOH617
CHOH620

site_idAC9
Number of Residues2
DetailsBINDING SITE FOR RESIDUE K C 503
ChainResidue
CTHR43
DPRO351

site_idBC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PO4 D 501
ChainResidue
DARG96
DARG180
DLYS205
DASN213
DVAL214

site_idBC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE I5R D 502
ChainResidue
DGLY63
DVAL70
DVAL110
DLEU132
DASP133
DTYR134
DVAL135
DPRO136
DLEU188
DCYS199
DASP200
DHOH622

site_idBC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE K D 503
ChainResidue
DTHR43

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGNGSFGVVYqAklcdsgelv.........AIKK
ChainResidueDetails
AILE62-LYS86

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IcHrDIKpqNLLL
ChainResidueDetails
AILE177-LEU189

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AASP181
BASP181
CASP181
DASP181

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AILE62
BILE62
CILE62
DILE62

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:17050006
ChainResidueDetails
ALYS85
BLYS85
CLYS85
DLYS85

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKB/AKT1, RPS6KA3 and SGK3 => ECO:0000269|PubMed:12054501, ECO:0000269|PubMed:16484495, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:24391509, ECO:0000269|PubMed:25169422, ECO:0000269|PubMed:8250835
ChainResidueDetails
ASER9
BSER9
CSER9
DSER9

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:25169422
ChainResidueDetails
APTR216
BPTR216
CPTR216
DPTR216

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9WV60
ChainResidueDetails
ASER389
BSER389
CSER389
DSER389

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR390
BTHR390
CTHR390
DTHR390

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976
ChainResidueDetails
ATHR402
BTHR402
CTHR402
DTHR402

218853

PDB entries from 2024-04-24

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