4IN1

Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 201

Chain	Residue
A	THR161
A	SER163
A	ASN165
A	THR166
A	HOH440

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: For 3CLpro activity => ECO:0000255|PROSITE-ProRule:PRU00870, ECO:0000269|PubMed:16641296, ECO:0000269|PubMed:23365454

Chain	Residue	Details
A	HIS30
A	GLU54
A	CYS139

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by 3CLpro => ECO:0000305|PubMed:17554035, ECO:0000305|PubMed:20976190

Chain	Residue	Details
A	GLU181

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