4IMZ

Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SCN A 201

Chain	Residue
A	PRO2
A	THR4
A	LEU5
A	ARG8

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA A 202

Chain	Residue
A	LYS0

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site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SCN A 203

Chain	Residue
A	HOH344
A	HOH366
A	HOH389
A	VAL82
A	SER84
A	HIS145
A	LYS146

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site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SCN A 204

Chain	Residue
A	HIS50
A	GLN172
A	ALA173

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site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SCN A 205

Chain	Residue
A	LYS37
A	HOH369
A	HOH403

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: For 3CLpro activity => ECO:0000255|PROSITE-ProRule:PRU00870, ECO:0000269|PubMed:16641296, ECO:0000269|PubMed:23365454

Chain	Residue	Details
A	HIS30
A	GLU54
A	CYS139

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by 3CLpro => ECO:0000305|PubMed:17554035, ECO:0000305|PubMed:20976190

Chain	Residue	Details
A	GLU181

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