4IFB
Crystal structure of SULT 2A1 LLGG mutant with PAPS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004027 | molecular_function | alcohol sulfotransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006068 | biological_process | ethanol catabolic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0008146 | molecular_function | sulfotransferase activity |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0008203 | biological_process | cholesterol metabolic process |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030573 | biological_process | bile acid catabolic process |
| A | 0042403 | biological_process | thyroid hormone metabolic process |
| A | 0047704 | molecular_function | bile-salt sulfotransferase activity |
| A | 0050294 | molecular_function | steroid sulfotransferase activity |
| A | 0050427 | biological_process | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| A | 0050656 | molecular_function | 3'-phosphoadenosine 5'-phosphosulfate binding |
| A | 0051923 | biological_process | sulfation |
| B | 0004027 | molecular_function | alcohol sulfotransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006068 | biological_process | ethanol catabolic process |
| B | 0006805 | biological_process | xenobiotic metabolic process |
| B | 0008146 | molecular_function | sulfotransferase activity |
| B | 0008202 | biological_process | steroid metabolic process |
| B | 0008203 | biological_process | cholesterol metabolic process |
| B | 0016042 | biological_process | lipid catabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030573 | biological_process | bile acid catabolic process |
| B | 0042403 | biological_process | thyroid hormone metabolic process |
| B | 0047704 | molecular_function | bile-salt sulfotransferase activity |
| B | 0050294 | molecular_function | steroid sulfotransferase activity |
| B | 0050427 | biological_process | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| B | 0050656 | molecular_function | 3'-phosphoadenosine 5'-phosphosulfate binding |
| B | 0051923 | biological_process | sulfation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 A 301 |
| Chain | Residue |
| A | LYS248 |
| A | ASP253 |
| A | HIS257 |
| site_id | AC2 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE PPS A 302 |
| Chain | Residue |
| A | TRP49 |
| A | HIS99 |
| A | ARG121 |
| A | SER129 |
| A | TYR184 |
| A | SER218 |
| A | SER219 |
| A | PHE220 |
| A | MET223 |
| A | LEU245 |
| A | LEU246 |
| A | ARG247 |
| A | LYS248 |
| A | GLY249 |
| A | HOH402 |
| A | HOH403 |
| A | HOH422 |
| A | HOH438 |
| A | HOH503 |
| A | PRO43 |
| A | LYS44 |
| A | SER45 |
| A | GLY46 |
| A | THR47 |
| A | ASN48 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 303 |
| Chain | Residue |
| A | ARG174 |
| A | GLU176 |
| A | PHE179 |
| A | HOH496 |
| A | HOH497 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 B 301 |
| Chain | Residue |
| B | LYS248 |
| B | ASP253 |
| B | ASN256 |
| B | HIS257 |
| site_id | AC5 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE PPS B 302 |
| Chain | Residue |
| B | PRO43 |
| B | LYS44 |
| B | SER45 |
| B | GLY46 |
| B | THR47 |
| B | ASN48 |
| B | TRP49 |
| B | HIS99 |
| B | ARG121 |
| B | SER129 |
| B | TYR184 |
| B | SER218 |
| B | SER219 |
| B | PHE220 |
| B | MET223 |
| B | LEU245 |
| B | LEU246 |
| B | ARG247 |
| B | LYS248 |
| B | GLY249 |
| B | HOH403 |
| B | HOH427 |
| B | HOH432 |
| B | HOH449 |
| B | HOH493 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 B 303 |
| Chain | Residue |
| B | HIS58 |
| B | LYS60 |
| B | LYS204 |
| B | HOH477 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 304 |
| Chain | Residue |
| B | ARG174 |
| B | GLU176 |
| B | PHE179 |
| B | HOH418 |
| B | HOH483 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 B 305 |
| Chain | Residue |
| B | TYR131 |
| B | PHE132 |
| B | HIS257 |
| B | HOH410 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:11988089, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1J99, ECO:0007744|PDB:1OV4 |
| Chain | Residue | Details |
| A | HIS99 | |
| B | HIS99 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10854859, ECO:0000269|PubMed:14573603, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:1OV4, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB |
| Chain | Residue | Details |
| A | LYS44 | |
| A | GLY46 | |
| A | ASN48 | |
| B | LYS44 | |
| B | GLY46 | |
| B | ASN48 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:3F3Y, ECO:0007744|PDB:4IFB |
| Chain | Residue | Details |
| A | SER45 | |
| B | SER45 | |
| B | THR47 | |
| B | TRP49 | |
| B | ARG121 | |
| B | SER129 | |
| B | SER218 | |
| B | ARG247 | |
| B | LYS248 | |
| B | GLY249 | |
| A | THR47 | |
| A | TRP49 | |
| A | ARG121 | |
| A | SER129 | |
| A | SER218 | |
| A | ARG247 | |
| A | LYS248 | |
| A | GLY249 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:4IFB |
| Chain | Residue | Details |
| A | TYR184 | |
| B | TYR184 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10854859, ECO:0007744|PDB:1EFH, ECO:0007744|PDB:4IFB |
| Chain | Residue | Details |
| A | MET223 | |
| B | MET223 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER251 | |
| B | SER251 |
