4IC8

Crystal structure of the apo ERK5 kinase domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004707	molecular_function	MAP kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004707	molecular_function	MAP kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGNGAYGVVSsArrrltgqqv.........AIKK

Chain	Residue	Details
A	ILE39-LYS63

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDLKpsNLLV

Chain	Residue	Details
A	VAL156-VAL168

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site_id	PS01351
Number of Residues	105
Details	MAPK MAP kinase signature. FdvvtnakrtlRElkilkhfkhdniiaikdilrptvpygefksvyvvldlmesdlhqiihssqpltlehvryflyqllrglkymhsaqvih........RDlKpsnllvnenC

Chain	Residue	Details
A	PHE68-CYS172

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP160
B	ASP160

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
B	ILE39
B	LYS62
A	ILE39
A	LYS62

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N-acetylalanine => ECO:0000269|Ref.7

Chain	Residue	Details
A	ALA-20
B	ALA-20

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