4I6Y
3-hydroxy-3-methyl (HMG) Coenzyme A Reductase bound to R-Mevalonate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| A | 0005778 | cellular_component | peroxisomal membrane |
| A | 0006696 | biological_process | ergosterol biosynthetic process |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0015936 | biological_process | coenzyme A metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0140643 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADH) activity |
| B | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| B | 0005778 | cellular_component | peroxisomal membrane |
| B | 0006696 | biological_process | ergosterol biosynthetic process |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0015936 | biological_process | coenzyme A metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0140643 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADH) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE MEV A 501 |
| Chain | Residue |
| A | GLU83 |
| B | HOH1247 |
| A | ARG261 |
| A | THR264 |
| A | LYS267 |
| A | ASN271 |
| A | ALA368 |
| A | HOH612 |
| B | ILE713 |
| B | HOH1160 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 502 |
| Chain | Residue |
| A | SER85 |
| A | ASN271 |
| A | GLN364 |
| A | ALA368 |
| A | HOH876 |
| A | HOH1039 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 503 |
| Chain | Residue |
| A | TYR294 |
| A | ARG297 |
| A | SER303 |
| A | HOH646 |
| A | HOH664 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 504 |
| Chain | Residue |
| A | ALA184 |
| A | MET185 |
| A | GLY186 |
| A | ALA187 |
| A | ASN188 |
| A | THR189 |
| A | GLY329 |
| A | HOH627 |
| A | HOH778 |
| A | HOH849 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 505 |
| Chain | Residue |
| A | ARG6 |
| A | PRO8 |
| A | ARG11 |
| A | ASN67 |
| A | LYS95 |
| A | HOH755 |
| A | HOH790 |
| A | HOH895 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 506 |
| Chain | Residue |
| A | ARG133 |
| A | HOH701 |
| B | ASN571 |
| B | ARG573 |
| B | HOH1103 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE MEV B 1001 |
| Chain | Residue |
| A | ILE213 |
| B | GLU583 |
| B | ARG761 |
| B | THR764 |
| B | LYS767 |
| B | ASN771 |
| B | ALA868 |
| B | LEU872 |
| B | HOH1124 |
| B | HOH1144 |
| B | HOH1167 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1002 |
| Chain | Residue |
| B | SER585 |
| B | ASN771 |
| B | GLN864 |
| B | ALA868 |
| B | HOH1327 |
| B | HOH1493 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 1003 |
| Chain | Residue |
| A | HOH616 |
| B | ASN600 |
| B | GLY602 |
| B | PHE603 |
| B | THR604 |
| B | GLN726 |
| B | ARG728 |
| B | HOH1104 |
| B | HOH1119 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1004 |
| Chain | Residue |
| B | ALA684 |
| B | MET685 |
| B | GLY686 |
| B | ALA687 |
| B | ASN688 |
| B | HOH1159 |
| B | HOH1232 |
| B | HOH1382 |
| B | HOH1502 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1005 |
| Chain | Residue |
| B | PRO508 |
| B | ALA509 |
| B | LYS595 |
| B | HOH1301 |
| B | HOH1449 |
| B | HOH1546 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1006 |
| Chain | Residue |
| B | ARG506 |
| B | ARG598 |
| B | HOH1273 |
| B | HOH1531 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NO2 B 1007 |
| Chain | Residue |
| A | LEU132 |
| A | ARG133 |
| A | LYS135 |
| B | SER606 |
| B | SER607 |
| B | ARG724 |
| B | HOH1234 |
| B | HOH1475 |
Functional Information from PROSITE/UniProt
| site_id | PS00066 |
| Number of Residues | 15 |
| Details | HMG_COA_REDUCTASE_1 Hydroxymethylglutaryl-coenzyme A reductases signature 1. HlIVdVRDaMGaNtV |
| Chain | Residue | Details |
| A | HIS176-VAL190 |
| site_id | PS00318 |
| Number of Residues | 8 |
| Details | HMG_COA_REDUCTASE_2 Hydroxymethylglutaryl-coenzyme A reductases signature 2. VGlVGGAT |
| Chain | Residue | Details |
| A | VAL325-THR332 |
| site_id | PS01192 |
| Number of Residues | 14 |
| Details | HMG_COA_REDUCTASE_3 Hydroxymethylglutaryl-coenzyme A reductases signature 3. ALaTegIqRGHMaL |
| Chain | Residue | Details |
| A | ALA371-LEU384 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| A | GLU83 | |
| A | LYS267 | |
| A | ASP283 | |
| B | GLU583 | |
| B | LYS767 | |
| B | ASP783 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU10003, ECO:0000269|PubMed:1634543 |
| Chain | Residue | Details |
| A | HIS381 | |
| B | HIS881 |
