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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4H8J

Structure of GluA2-LBD in complex with MES

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE MES A 301

Chain	Residue
A	GLU13
A	HOH633
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLU193
A	MET196
A	TYR220

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 302

Chain	Residue
A	THR143
A	LEU192
A	GLU193
A	HOH455
A	HOH475
A	HOH549
A	HOH593

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 303

Chain	Residue
A	LYS50
A	ARG148
A	TRP159
A	ARG163
A	HOH617

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 304

Chain	Residue
A	ASP139
A	SER140
A	LYS144
A	ARG148
B	ARG172

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 305

Chain	Residue
A	LYS116
A	LYS185
A	GLY186
A	HOH462
D	ILE70
D	TYR80

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 306

Chain	Residue
A	PRO167
A	HOH417
B	PRO167
B	HOH417

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 301

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLU193
B	EDO304
B	HOH586

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 302

Chain	Residue
B	ARG148
B	TRP159
B	ARG163

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 303

Chain	Residue
A	ARG172
B	ASP139
B	LYS144
B	ARG148

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO B 304

Chain	Residue
B	TYR61
B	PRO89
B	GLU193
B	MET196
B	TYR220
B	SO4301
B	HOH464

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MES C 301

Chain	Residue
C	GLU13
C	TYR61
C	PRO89
C	THR91
C	ARG96
C	GLU193
C	TYR220
C	HOH507
C	HOH655

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 C 302

Chain	Residue
C	THR143
C	LEU192
C	GLU193
C	HOH407
C	HOH434
C	HOH438
C	HOH572
C	HOH602
C	HOH624

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 303

Chain	Residue
C	ARG148
C	TRP159
C	ARG163
D	LYS50

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 304

Chain	Residue
C	ASP139
C	SER140
C	LYS144
C	ARG148
D	ARG172

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 305

Chain	Residue
C	PRO167
C	HOH453
D	PRO167
D	HOH410

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 301

Chain	Residue
D	TYR61
D	PRO89
D	THR91
D	ARG96
D	EDO304
D	HOH664

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 302

Chain	Residue
D	ARG148
D	HOH674
C	ARG172
D	ASP139
D	LYS144

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 303

Chain	Residue
D	ARG148
D	TRP159
D	ARG163

site_id	CC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO D 304

Chain	Residue
D	TYR61
D	PRO89
D	GLU193
D	MET196
D	TYR220
D	SO4301
D	HOH456

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:16483599

Chain	Residue	Details
B	ARG96
B	GLU193
C	TYR61
C	ARG96
C	GLU193
D	TYR61
D	ARG96
D	GLU193
A	TYR61
A	ARG96
A	GLU193
B	TYR61

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	PRO89
B	PRO89
C	PRO89
D	PRO89

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:25103405

Chain	Residue	Details
C	THR143
D	THR91
D	SER142
D	THR143
A	THR91
A	SER142
A	THR143
B	THR91
B	SER142
B	THR143
C	THR91
C	SER142

site_id	SWS_FT_FI4
Number of Residues	12
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269\|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240
B	ARG64
B	ARG148
B	LYS240
C	ARG64
C	ARG148
C	LYS240
D	ARG64
D	ARG148
D	LYS240

site_id	SWS_FT_FI5
Number of Residues	4
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269\|PubMed:25103405

Chain	Residue	Details
A	ILE121
B	ILE121
C	ILE121
D	ILE121

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269\|PubMed:8848293

Chain	Residue	Details
A	SER150
B	SER150
C	SER150
D	SER150

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269\|PubMed:8848293

Chain	Residue	Details
A	SER184
B	SER184
C	SER184
D	SER184

site_id	SWS_FT_FI8
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3
C	ASN3
D	ASN3

219869

PDB entries from 2024-05-15

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