4GRO

Crystallographic and biological characterization of N- and C- terminus mutants of human MIF

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001516	biological_process	prostaglandin biosynthetic process
A	0001819	biological_process	positive regulation of cytokine production
A	0001934	biological_process	positive regulation of protein phosphorylation
A	0002020	molecular_function	protease binding
A	0002906	biological_process	negative regulation of mature B cell apoptotic process
A	0004167	molecular_function	dopachrome isomerase activity
A	0005125	molecular_function	cytokine activity
A	0005126	molecular_function	cytokine receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006954	biological_process	inflammatory response
A	0007166	biological_process	cell surface receptor signaling pathway
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009986	cellular_component	cell surface
A	0010629	biological_process	negative regulation of gene expression
A	0010739	biological_process	positive regulation of protein kinase A signaling
A	0010760	biological_process	negative regulation of macrophage chemotaxis
A	0016853	molecular_function	isomerase activity
A	0019752	biological_process	carboxylic acid metabolic process
A	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
A	0030336	biological_process	negative regulation of cell migration
A	0030890	biological_process	positive regulation of B cell proliferation
A	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
A	0031982	cellular_component	vesicle
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0033033	biological_process	negative regulation of myeloid cell apoptotic process
A	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
A	0034774	cellular_component	secretory granule lumen
A	0042056	molecular_function	chemoattractant activity
A	0042127	biological_process	regulation of cell population proliferation
A	0042327	biological_process	positive regulation of phosphorylation
A	0042802	molecular_function	identical protein binding
A	0043030	biological_process	regulation of macrophage activation
A	0043066	biological_process	negative regulation of apoptotic process
A	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
A	0045087	biological_process	innate immune response
A	0048146	biological_process	positive regulation of fibroblast proliferation
A	0050178	molecular_function	phenylpyruvate tautomerase activity
A	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
A	0050918	biological_process	positive chemotaxis
A	0051248	biological_process	negative regulation of protein metabolic process
A	0061078	biological_process	positive regulation of prostaglandin secretion involved in immune response
A	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
A	0070062	cellular_component	extracellular exosome
A	0070207	biological_process	protein homotrimerization
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	0090238	biological_process	positive regulation of arachidonic acid secretion
A	0090398	biological_process	cellular senescence
A	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
A	2000773	biological_process	negative regulation of cellular senescence
B	0001516	biological_process	prostaglandin biosynthetic process
B	0001819	biological_process	positive regulation of cytokine production
B	0001934	biological_process	positive regulation of protein phosphorylation
B	0002020	molecular_function	protease binding
B	0002906	biological_process	negative regulation of mature B cell apoptotic process
B	0004167	molecular_function	dopachrome isomerase activity
B	0005125	molecular_function	cytokine activity
B	0005126	molecular_function	cytokine receptor binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006954	biological_process	inflammatory response
B	0007166	biological_process	cell surface receptor signaling pathway
B	0008284	biological_process	positive regulation of cell population proliferation
B	0009986	cellular_component	cell surface
B	0010629	biological_process	negative regulation of gene expression
B	0010739	biological_process	positive regulation of protein kinase A signaling
B	0010760	biological_process	negative regulation of macrophage chemotaxis
B	0016853	molecular_function	isomerase activity
B	0019752	biological_process	carboxylic acid metabolic process
B	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
B	0030336	biological_process	negative regulation of cell migration
B	0030890	biological_process	positive regulation of B cell proliferation
B	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
B	0031982	cellular_component	vesicle
B	0032760	biological_process	positive regulation of tumor necrosis factor production
B	0033033	biological_process	negative regulation of myeloid cell apoptotic process
B	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
B	0034774	cellular_component	secretory granule lumen
B	0042056	molecular_function	chemoattractant activity
B	0042127	biological_process	regulation of cell population proliferation
B	0042327	biological_process	positive regulation of phosphorylation
B	0042802	molecular_function	identical protein binding
B	0043030	biological_process	regulation of macrophage activation
B	0043066	biological_process	negative regulation of apoptotic process
B	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
B	0045087	biological_process	innate immune response
B	0048146	biological_process	positive regulation of fibroblast proliferation
B	0050178	molecular_function	phenylpyruvate tautomerase activity
B	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
B	0050918	biological_process	positive chemotaxis
B	0051248	biological_process	negative regulation of protein metabolic process
B	0061078	biological_process	positive regulation of prostaglandin secretion involved in immune response
B	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
B	0070062	cellular_component	extracellular exosome
B	0070207	biological_process	protein homotrimerization
B	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
B	0090238	biological_process	positive regulation of arachidonic acid secretion
B	0090398	biological_process	cellular senescence
B	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
B	2000773	biological_process	negative regulation of cellular senescence
C	0001516	biological_process	prostaglandin biosynthetic process
C	0001819	biological_process	positive regulation of cytokine production
C	0001934	biological_process	positive regulation of protein phosphorylation
C	0002020	molecular_function	protease binding
C	0002906	biological_process	negative regulation of mature B cell apoptotic process
C	0004167	molecular_function	dopachrome isomerase activity
C	0005125	molecular_function	cytokine activity
C	0005126	molecular_function	cytokine receptor binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006954	biological_process	inflammatory response
C	0007166	biological_process	cell surface receptor signaling pathway
C	0008284	biological_process	positive regulation of cell population proliferation
C	0009986	cellular_component	cell surface
C	0010629	biological_process	negative regulation of gene expression
C	0010739	biological_process	positive regulation of protein kinase A signaling
C	0010760	biological_process	negative regulation of macrophage chemotaxis
C	0016853	molecular_function	isomerase activity
C	0019752	biological_process	carboxylic acid metabolic process
C	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
C	0030336	biological_process	negative regulation of cell migration
C	0030890	biological_process	positive regulation of B cell proliferation
C	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
C	0031982	cellular_component	vesicle
C	0032760	biological_process	positive regulation of tumor necrosis factor production
C	0033033	biological_process	negative regulation of myeloid cell apoptotic process
C	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
C	0034774	cellular_component	secretory granule lumen
C	0042056	molecular_function	chemoattractant activity
C	0042127	biological_process	regulation of cell population proliferation
C	0042327	biological_process	positive regulation of phosphorylation
C	0042802	molecular_function	identical protein binding
C	0043030	biological_process	regulation of macrophage activation
C	0043066	biological_process	negative regulation of apoptotic process
C	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
C	0045087	biological_process	innate immune response
C	0048146	biological_process	positive regulation of fibroblast proliferation
C	0050178	molecular_function	phenylpyruvate tautomerase activity
C	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
C	0050918	biological_process	positive chemotaxis
C	0051248	biological_process	negative regulation of protein metabolic process
C	0061078	biological_process	positive regulation of prostaglandin secretion involved in immune response
C	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
C	0070062	cellular_component	extracellular exosome
C	0070207	biological_process	protein homotrimerization
C	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
C	0090238	biological_process	positive regulation of arachidonic acid secretion
C	0090398	biological_process	cellular senescence
C	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
C	1904813	cellular_component	ficolin-1-rich granule lumen
C	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
C	2000773	biological_process	negative regulation of cellular senescence
D	0001516	biological_process	prostaglandin biosynthetic process
D	0001819	biological_process	positive regulation of cytokine production
D	0001934	biological_process	positive regulation of protein phosphorylation
D	0002020	molecular_function	protease binding
D	0002906	biological_process	negative regulation of mature B cell apoptotic process
D	0004167	molecular_function	dopachrome isomerase activity
D	0005125	molecular_function	cytokine activity
D	0005126	molecular_function	cytokine receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006954	biological_process	inflammatory response
D	0007166	biological_process	cell surface receptor signaling pathway
D	0008284	biological_process	positive regulation of cell population proliferation
D	0009986	cellular_component	cell surface
D	0010629	biological_process	negative regulation of gene expression
D	0010739	biological_process	positive regulation of protein kinase A signaling
D	0010760	biological_process	negative regulation of macrophage chemotaxis
D	0016853	molecular_function	isomerase activity
D	0019752	biological_process	carboxylic acid metabolic process
D	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
D	0030336	biological_process	negative regulation of cell migration
D	0030890	biological_process	positive regulation of B cell proliferation
D	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
D	0031982	cellular_component	vesicle
D	0032760	biological_process	positive regulation of tumor necrosis factor production
D	0033033	biological_process	negative regulation of myeloid cell apoptotic process
D	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
D	0034774	cellular_component	secretory granule lumen
D	0042056	molecular_function	chemoattractant activity
D	0042127	biological_process	regulation of cell population proliferation
D	0042327	biological_process	positive regulation of phosphorylation
D	0042802	molecular_function	identical protein binding
D	0043030	biological_process	regulation of macrophage activation
D	0043066	biological_process	negative regulation of apoptotic process
D	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
D	0045087	biological_process	innate immune response
D	0048146	biological_process	positive regulation of fibroblast proliferation
D	0050178	molecular_function	phenylpyruvate tautomerase activity
D	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
D	0050918	biological_process	positive chemotaxis
D	0051248	biological_process	negative regulation of protein metabolic process
D	0061078	biological_process	positive regulation of prostaglandin secretion involved in immune response
D	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
D	0070062	cellular_component	extracellular exosome
D	0070207	biological_process	protein homotrimerization
D	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
D	0090238	biological_process	positive regulation of arachidonic acid secretion
D	0090398	biological_process	cellular senescence
D	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
D	1904813	cellular_component	ficolin-1-rich granule lumen
D	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
D	2000773	biological_process	negative regulation of cellular senescence
E	0001516	biological_process	prostaglandin biosynthetic process
E	0001819	biological_process	positive regulation of cytokine production
E	0001934	biological_process	positive regulation of protein phosphorylation
E	0002020	molecular_function	protease binding
E	0002906	biological_process	negative regulation of mature B cell apoptotic process
E	0004167	molecular_function	dopachrome isomerase activity
E	0005125	molecular_function	cytokine activity
E	0005126	molecular_function	cytokine receptor binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006954	biological_process	inflammatory response
E	0007166	biological_process	cell surface receptor signaling pathway
E	0008284	biological_process	positive regulation of cell population proliferation
E	0009986	cellular_component	cell surface
E	0010629	biological_process	negative regulation of gene expression
E	0010739	biological_process	positive regulation of protein kinase A signaling
E	0010760	biological_process	negative regulation of macrophage chemotaxis
E	0016853	molecular_function	isomerase activity
E	0019752	biological_process	carboxylic acid metabolic process
E	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
E	0030336	biological_process	negative regulation of cell migration
E	0030890	biological_process	positive regulation of B cell proliferation
E	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
E	0031982	cellular_component	vesicle
E	0032760	biological_process	positive regulation of tumor necrosis factor production
E	0033033	biological_process	negative regulation of myeloid cell apoptotic process
E	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
E	0034774	cellular_component	secretory granule lumen
E	0042056	molecular_function	chemoattractant activity
E	0042127	biological_process	regulation of cell population proliferation
E	0042327	biological_process	positive regulation of phosphorylation
E	0042802	molecular_function	identical protein binding
E	0043030	biological_process	regulation of macrophage activation
E	0043066	biological_process	negative regulation of apoptotic process
E	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
E	0045087	biological_process	innate immune response
E	0048146	biological_process	positive regulation of fibroblast proliferation
E	0050178	molecular_function	phenylpyruvate tautomerase activity
E	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
E	0050918	biological_process	positive chemotaxis
E	0051248	biological_process	negative regulation of protein metabolic process
E	0061078	biological_process	positive regulation of prostaglandin secretion involved in immune response
E	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
E	0070062	cellular_component	extracellular exosome
E	0070207	biological_process	protein homotrimerization
E	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
E	0090238	biological_process	positive regulation of arachidonic acid secretion
E	0090398	biological_process	cellular senescence
E	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
E	1904813	cellular_component	ficolin-1-rich granule lumen
E	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
E	2000773	biological_process	negative regulation of cellular senescence
F	0001516	biological_process	prostaglandin biosynthetic process
F	0001819	biological_process	positive regulation of cytokine production
F	0001934	biological_process	positive regulation of protein phosphorylation
F	0002020	molecular_function	protease binding
F	0002906	biological_process	negative regulation of mature B cell apoptotic process
F	0004167	molecular_function	dopachrome isomerase activity
F	0005125	molecular_function	cytokine activity
F	0005126	molecular_function	cytokine receptor binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006954	biological_process	inflammatory response
F	0007166	biological_process	cell surface receptor signaling pathway
F	0008284	biological_process	positive regulation of cell population proliferation
F	0009986	cellular_component	cell surface
F	0010629	biological_process	negative regulation of gene expression
F	0010739	biological_process	positive regulation of protein kinase A signaling
F	0010760	biological_process	negative regulation of macrophage chemotaxis
F	0016853	molecular_function	isomerase activity
F	0019752	biological_process	carboxylic acid metabolic process
F	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
F	0030336	biological_process	negative regulation of cell migration
F	0030890	biological_process	positive regulation of B cell proliferation
F	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
F	0031982	cellular_component	vesicle
F	0032760	biological_process	positive regulation of tumor necrosis factor production
F	0033033	biological_process	negative regulation of myeloid cell apoptotic process
F	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
F	0034774	cellular_component	secretory granule lumen
F	0042056	molecular_function	chemoattractant activity
F	0042127	biological_process	regulation of cell population proliferation
F	0042327	biological_process	positive regulation of phosphorylation
F	0042802	molecular_function	identical protein binding
F	0043030	biological_process	regulation of macrophage activation
F	0043066	biological_process	negative regulation of apoptotic process
F	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
F	0045087	biological_process	innate immune response
F	0048146	biological_process	positive regulation of fibroblast proliferation
F	0050178	molecular_function	phenylpyruvate tautomerase activity
F	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
F	0050918	biological_process	positive chemotaxis
F	0051248	biological_process	negative regulation of protein metabolic process
F	0061078	biological_process	positive regulation of prostaglandin secretion involved in immune response
F	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
F	0070062	cellular_component	extracellular exosome
F	0070207	biological_process	protein homotrimerization
F	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
F	0090238	biological_process	positive regulation of arachidonic acid secretion
F	0090398	biological_process	cellular senescence
F	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
F	1904813	cellular_component	ficolin-1-rich granule lumen
F	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
F	2000773	biological_process	negative regulation of cellular senescence
G	0001516	biological_process	prostaglandin biosynthetic process
G	0001819	biological_process	positive regulation of cytokine production
G	0001934	biological_process	positive regulation of protein phosphorylation
G	0002020	molecular_function	protease binding
G	0002906	biological_process	negative regulation of mature B cell apoptotic process
G	0004167	molecular_function	dopachrome isomerase activity
G	0005125	molecular_function	cytokine activity
G	0005126	molecular_function	cytokine receptor binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006954	biological_process	inflammatory response
G	0007166	biological_process	cell surface receptor signaling pathway
G	0008284	biological_process	positive regulation of cell population proliferation
G	0009986	cellular_component	cell surface
G	0010629	biological_process	negative regulation of gene expression
G	0010739	biological_process	positive regulation of protein kinase A signaling
G	0010760	biological_process	negative regulation of macrophage chemotaxis
G	0016853	molecular_function	isomerase activity
G	0019752	biological_process	carboxylic acid metabolic process
G	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
G	0030336	biological_process	negative regulation of cell migration
G	0030890	biological_process	positive regulation of B cell proliferation
G	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
G	0031982	cellular_component	vesicle
G	0032760	biological_process	positive regulation of tumor necrosis factor production
G	0033033	biological_process	negative regulation of myeloid cell apoptotic process
G	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
G	0034774	cellular_component	secretory granule lumen
G	0042056	molecular_function	chemoattractant activity
G	0042127	biological_process	regulation of cell population proliferation
G	0042327	biological_process	positive regulation of phosphorylation
G	0042802	molecular_function	identical protein binding
G	0043030	biological_process	regulation of macrophage activation
G	0043066	biological_process	negative regulation of apoptotic process
G	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
G	0045087	biological_process	innate immune response
G	0048146	biological_process	positive regulation of fibroblast proliferation
G	0050178	molecular_function	phenylpyruvate tautomerase activity
G	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
G	0050918	biological_process	positive chemotaxis
G	0051248	biological_process	negative regulation of protein metabolic process
G	0061078	biological_process	positive regulation of prostaglandin secretion involved in immune response
G	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
G	0070062	cellular_component	extracellular exosome
G	0070207	biological_process	protein homotrimerization
G	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
G	0090238	biological_process	positive regulation of arachidonic acid secretion
G	0090398	biological_process	cellular senescence
G	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
G	1904813	cellular_component	ficolin-1-rich granule lumen
G	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
G	2000773	biological_process	negative regulation of cellular senescence
H	0001516	biological_process	prostaglandin biosynthetic process
H	0001819	biological_process	positive regulation of cytokine production
H	0001934	biological_process	positive regulation of protein phosphorylation
H	0002020	molecular_function	protease binding
H	0002906	biological_process	negative regulation of mature B cell apoptotic process
H	0004167	molecular_function	dopachrome isomerase activity
H	0005125	molecular_function	cytokine activity
H	0005126	molecular_function	cytokine receptor binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006954	biological_process	inflammatory response
H	0007166	biological_process	cell surface receptor signaling pathway
H	0008284	biological_process	positive regulation of cell population proliferation
H	0009986	cellular_component	cell surface
H	0010629	biological_process	negative regulation of gene expression
H	0010739	biological_process	positive regulation of protein kinase A signaling
H	0010760	biological_process	negative regulation of macrophage chemotaxis
H	0016853	molecular_function	isomerase activity
H	0019752	biological_process	carboxylic acid metabolic process
H	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
H	0030336	biological_process	negative regulation of cell migration
H	0030890	biological_process	positive regulation of B cell proliferation
H	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
H	0031982	cellular_component	vesicle
H	0032760	biological_process	positive regulation of tumor necrosis factor production
H	0033033	biological_process	negative regulation of myeloid cell apoptotic process
H	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
H	0034774	cellular_component	secretory granule lumen
H	0042056	molecular_function	chemoattractant activity
H	0042127	biological_process	regulation of cell population proliferation
H	0042327	biological_process	positive regulation of phosphorylation
H	0042802	molecular_function	identical protein binding
H	0043030	biological_process	regulation of macrophage activation
H	0043066	biological_process	negative regulation of apoptotic process
H	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
H	0045087	biological_process	innate immune response
H	0048146	biological_process	positive regulation of fibroblast proliferation
H	0050178	molecular_function	phenylpyruvate tautomerase activity
H	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
H	0050918	biological_process	positive chemotaxis
H	0051248	biological_process	negative regulation of protein metabolic process
H	0061078	biological_process	positive regulation of prostaglandin secretion involved in immune response
H	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
H	0070062	cellular_component	extracellular exosome
H	0070207	biological_process	protein homotrimerization
H	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
H	0090238	biological_process	positive regulation of arachidonic acid secretion
H	0090398	biological_process	cellular senescence
H	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
H	1904813	cellular_component	ficolin-1-rich granule lumen
H	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
H	2000773	biological_process	negative regulation of cellular senescence

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 201

Chain	Residue
B	ASN105
B	ASN108
D	HOH215

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 201

Chain	Residue
B	HOH321
C	ASN105
C	ASN108

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 201

Chain	Residue
E	ASN100
F	MET5
F	HOH352

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL E 202

Chain	Residue
E	GLY71
E	GLY72
E	ALA73
E	GLN74

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL F 201

Chain	Residue
F	GLY71
F	GLY72
F	ALA73
F	GLN74

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G 201

Chain	Residue
G	GLY71
G	GLY72
G	GLN74

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL G 202

Chain	Residue
G	MET5
G	ASN100

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL H 201

Chain	Residue
E	MET5
H	ASN100

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL H 202

Chain	Residue
F	ASN100
H	MET5

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL H 203

Chain	Residue
H	GLY71
H	GLY72
H	ALA73
H	GLN74

---

Functional Information from PROSITE/UniProt

site_id	PS01158
Number of Residues	15
Details	MIF Macrophage migration inhibitory factor family signature. EPCAlcsLhSIGkIG

Chain	Residue	Details
A	GLU57-GLY71

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton acceptor; via imino nitrogen => ECO:0000250|UniProtKB:P34884

Chain	Residue	Details
B	PRO1
C	PRO1
D	PRO1
E	PRO1
F	PRO1
G	PRO1
H	PRO1
A	PRO1

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677

Chain	Residue	Details
F	ILE67
F	ASN100
G	LYS35
G	ILE67
G	ASN100
H	LYS35
H	ILE67
H	ASN100
F	LYS35
A	LYS35
A	ILE67
A	ASN100
B	LYS35
B	ILE67
B	ASN100
C	LYS35
C	ILE67
C	ASN100
D	LYS35
D	ILE67
D	ASN100
E	LYS35
E	ILE67
E	ASN100

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P34884

Chain	Residue	Details
F	LYS80
G	LYS80
H	LYS80
A	LYS80
B	LYS80
C	LYS80
D	LYS80
E	LYS80

---