4GC3

Crystal structure of L-HISTIDINOL PHOSPHATE PHOSPHATASE (HISK) from Lactococcus lactis subsp. lactis Il1403 complexed with ZN and sulfate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000105	biological_process	histidine biosynthetic process
A	0003824	molecular_function	catalytic activity
A	0004401	molecular_function	histidinol-phosphatase activity
A	0005737	cellular_component	cytoplasm
A	0008652	biological_process	amino acid biosynthetic process
A	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	ASP17
A	HIS42
A	HIS230
A	SO4304

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN A 302

Chain	Residue
A	ZN303
A	HOH785
A	HIS9
A	HIS11
A	HIS42
A	GLU81
A	ASP228

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 303

Chain	Residue
A	GLU81
A	HIS109
A	HIS154
A	ZN302
A	HOH785

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site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SO4 A 304

Chain	Residue
A	ASP17
A	HIS42
A	TYR157
A	ARG160
A	TYR161
A	ASP228
A	HIS230
A	ZN301
A	HOH531
A	HOH629
A	HOH655
A	HOH744
A	HOH785
A	HOH809

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site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 305

Chain	Residue
A	LYS5
A	THR127
A	HIS240
A	ARG243
A	LYS247
A	HOH470
A	HOH475
A	HOH508

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site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 306

Chain	Residue
A	ARG175
A	LYS233
A	HOH661
A	HOH666
A	HOH698
A	HOH748

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