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4ESW

Crystal structure of C. albicans Thi5 H66G mutant

Functional Information from GO Data
ChainGOidnamespacecontents
A0009228biological_processthiamine biosynthetic process
A0009229biological_processthiamine diphosphate biosynthetic process
A0016740molecular_functiontransferase activity
A0046872molecular_functionmetal ion binding
A0106344molecular_function4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP
B0009228biological_processthiamine biosynthetic process
B0009229biological_processthiamine diphosphate biosynthetic process
B0016740molecular_functiontransferase activity
B0046872molecular_functionmetal ion binding
B0106344molecular_function4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP
Functional Information from PDB Data
site_idAC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE CIT A 900
ChainResidue
ALYS62
AHOH1045
AHOH1058
AHOH1089
AHOH1172
AHOH1283
AHOH1412
AALA63
AVAL65
AGLY66
AGLY115
AGLU116
APHE117
AGLY118
AHOH1004

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE CIT B 900
ChainResidue
BLYS62
BALA63
BVAL65
BGLY66
BGLY115
BGLU116
BPHE117
BGLY118
BHOH1027
BHOH1096
BHOH1173

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000305|PubMed:22568620
ChainResidueDetails
AGLY66
BGLY66

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:22568620
ChainResidueDetails
AGLY115
BGLY115

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:22568620
ChainResidueDetails
ALYS62
BLYS62

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PDB entries from 2024-05-15

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