4ER4

HIGH-RESOLUTION X-RAY ANALYSES OF RENIN INHIBITOR-ASPARTIC PROTEINASE COMPLEXES

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004190	molecular_function	aspartic-type endopeptidase activity
E	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	BINDING SITE FOR CHAIN I OF H-142

Chain	Residue
E	TYR75
E	GLY76
E	ASP77
E	GLU113
E	ASP114
E	LEU120
E	LEU128
E	PHE189
E	ILE213
E	ASP215
E	GLY217
E	THR218
E	THR219
E	PHE275
E	PRO277
E	PHE284
I	HOH344
E	LEU10
E	ASP12
E	ALA13
E	ASP30
E	ASP32
E	GLY34
E	SER74

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site_id	CAT
Number of Residues	2
Details

Chain	Residue
E	ASP32
E	ASP215

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Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LDFDTGSSDLWV

Chain	Residue	Details
E	LEU29-VAL40
E	GLY212-LEU223

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE:

Chain	Residue	Details
E	ASP32
E	SER194

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP32

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215

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site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215
E	SER35
E	THR218
E	ASP32

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site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215
E	THR216
E	ASP32
E	THR33

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site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215
E	SER35
E	ASP32

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site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215
E	THR218
E	ASP32
E	THR33

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