4ER2

The active site of aspartic proteinases

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004190	molecular_function	aspartic-type endopeptidase activity
E	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 E 910

Chain	Residue
E	HOH1097
E	SER108
E	SER109
E	THR318
E	THR319
E	HOH990
E	HOH1057
E	HOH1096

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 920

Chain	Residue
E	SER132
E	PRO133
E	HOH1054

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 930

Chain	Residue
E	TYR175
E	SER178
E	ILE179
E	HOH1132

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site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR CHAIN I OF PEPSTATIN

Chain	Residue
E	ASP32
E	GLY34
E	SER74
E	TYR75
E	GLY76
E	ASP77
E	PHE189
E	ASP215
E	GLY217
E	THR218
E	THR219
I	HOH7
I	HOH8

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site_id	CAT
Number of Residues	2
Details

Chain	Residue
E	ASP32
E	ASP215

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Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LDFDTGSSDLWV

Chain	Residue	Details
E	LEU29-VAL40
E	GLY212-LEU223

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE:

Chain	Residue	Details
E	ASP32
E	SER194

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