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4DRH

Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of mTOR at low pH

Functional Information from GO Data
ChainGOidnamespacecontents
A0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
B0044877molecular_functionprotein-containing complex binding
D0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
E0044877molecular_functionprotein-containing complex binding
Functional Information from PDB Data
site_idAC1
Number of Residues21
DetailsBINDING SITE FOR RESIDUE RAP A 201
ChainResidue
ATYR57
ATRP90
ATYR113
ALYS121
APHE130
BLEU2031
BSER2035
BPHE2039
BTHR2098
BTRP2101
BASP2102
APHE67
BTYR2105
BPHE2108
AASP68
AHIS71
APHE77
AGLY84
AGLN85
AVAL86
AILE87

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 A 202
ChainResidue
AASP68
ASER69
ASER70
ALYS121
AHOH309
AHOH319
AHOH320
BLYS2095
BTHR2098

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 203
ChainResidue
ALYS58
ALYS60
ALYS66

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 204
ChainResidue
ASER13
APRO14
ATHR15
ALYS60
AHOH317

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 205
ChainResidue
AARG31
AARG31
ALYS108
ALYS108

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 206
ChainResidue
ALYS52
ATYR54
BSER2069
BARG2110

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 207
ChainResidue
ATHR26
ASER27
ALYS28
ATYR111

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 208
ChainResidue
AGLU12
APRO14
ALYS38
AHIS104
AHOH324
AHOH326

site_idAC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 B 2201
ChainResidue
ALYS99
AASP136
BTHR2064
BLEU2065
BHOH2321

site_idBC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 B 2202
ChainResidue
BLYS2045
BARG2086

site_idBC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 B 2203
ChainResidue
BTYR2074
BARG2110
BARG2110

site_idBC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 B 2204
ChainResidue
AGLU75
BGLN2072
BARG2076
BHIS2106
BARG2109
BHOH2308
BHOH2325

site_idBC4
Number of Residues22
DetailsBINDING SITE FOR RESIDUE RAP D 201
ChainResidue
BHOH2316
DTYR57
DPHE67
DASP68
DHIS71
DPHE77
DGLY84
DGLN85
DVAL86
DILE87
DTRP90
DTYR113
DPHE130
ELEU2031
ESER2035
EARG2036
EPHE2039
ETHR2098
ETRP2101
EASP2102
ETYR2105
EPHE2108

site_idBC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 D 202
ChainResidue
DSER13
DPRO14
DTHR15
DLYS60

site_idBC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 D 203
ChainResidue
DGLU12
DPRO14
DLYS38
DHIS104

site_idBC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 D 204
ChainResidue
DPHE67
DASP68
DSER69
DSER70
DHOH317

site_idBC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 D 205
ChainResidue
DLYS58
DLYS60
DLYS66

site_idBC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 E 2201
ChainResidue
ETYR2105
EHIS2106
EARG2109
EHOH2302

site_idCC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 E 2202
ChainResidue
ELYS2045
EARG2086
EHOH2307

site_idCC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 E 2203
ChainResidue
DLYS52
DTYR54
EARG2109

site_idCC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 E 2204
ChainResidue
BHIS2028
BGLU2029
BGLU2032
EHIS2028
EGLU2029
EGLU2032

site_idCC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 E 2205
ChainResidue
EGLN2082
EHOH2305

site_idCC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 E 2206
ChainResidue
DARG39
EASP2077
EHIS2106

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330
ChainResidueDetails
AMET1
DMET1

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER13
DSER13

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:28147277
ChainResidueDetails
ALYS28
DLYS28

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PDB entries from 2024-05-01

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