4D4K

human PFKFB3 in complex with a pyrrolopyrimidone compound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003873	molecular_function	6-phosphofructo-2-kinase activity
A	0005524	molecular_function	ATP binding
A	0006000	biological_process	fructose metabolic process
A	0006003	biological_process	fructose 2,6-bisphosphate metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00175
Number of Residues	10
Details	PG_MUTASE Phosphoglycerate mutase family phosphohistidine signature. LcRHGEnEhN

Chain	Residue	Details
A	LEU250-ASN259

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255

Chain	Residue	Details
A	ASP124
A	CYS154

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Tele-phosphohistidine intermediate => ECO:0000269|PubMed:22275052

Chain	Residue	Details
A	HIS253

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site_id	SWS_FT_FI3
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:22275052

Chain	Residue	Details
A	GLU322

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site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:16316985, ECO:0000269|PubMed:17499765, ECO:0000269|PubMed:22275052

Chain	Residue	Details
A	GLY41
A	ASN163
A	TYR424

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site_id	SWS_FT_FI5
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269|PubMed:16316985

Chain	Residue	Details
A	ARG74
A	ARG98
A	THR126
A	ARG132
A	LYS168
A	ARG189
A	TYR193

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:25849762

Chain	Residue	Details
A	ARG252
A	ASN259
A	GLY265
A	TYR333
A	ARG347
A	LYS351
A	TYR362
A	GLN388

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site_id	SWS_FT_FI7
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P07953

Chain	Residue	Details
A	TYR344
A	ARG392

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site_id	SWS_FT_FI8
Number of Residues	3
Details	SITE: Transition state stabilizer => ECO:0000269|PubMed:22275052

Chain	Residue	Details
A	ARG252
A	ASN259
A	HIS387

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