4CQ5
Structural Investigations into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus chinensis
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006558 | biological_process | L-phenylalanine metabolic process |
A | 0006559 | biological_process | L-phenylalanine catabolic process |
A | 0009698 | biological_process | phenylpropanoid metabolic process |
A | 0009800 | biological_process | cinnamic acid biosynthetic process |
A | 0009820 | biological_process | alkaloid metabolic process |
A | 0009821 | biological_process | alkaloid biosynthetic process |
A | 0016829 | molecular_function | lyase activity |
A | 0016841 | molecular_function | ammonia-lyase activity |
A | 0016853 | molecular_function | isomerase activity |
A | 0016869 | molecular_function | intramolecular aminotransferase activity |
A | 0042617 | biological_process | paclitaxel biosynthetic process |
A | 0045548 | molecular_function | phenylalanine ammonia-lyase activity |
A | 0051289 | biological_process | protein homotetramerization |
B | 0003824 | molecular_function | catalytic activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006558 | biological_process | L-phenylalanine metabolic process |
B | 0006559 | biological_process | L-phenylalanine catabolic process |
B | 0009698 | biological_process | phenylpropanoid metabolic process |
B | 0009800 | biological_process | cinnamic acid biosynthetic process |
B | 0009820 | biological_process | alkaloid metabolic process |
B | 0009821 | biological_process | alkaloid biosynthetic process |
B | 0016829 | molecular_function | lyase activity |
B | 0016841 | molecular_function | ammonia-lyase activity |
B | 0016853 | molecular_function | isomerase activity |
B | 0016869 | molecular_function | intramolecular aminotransferase activity |
B | 0042617 | biological_process | paclitaxel biosynthetic process |
B | 0045548 | molecular_function | phenylalanine ammonia-lyase activity |
B | 0051289 | biological_process | protein homotetramerization |
C | 0003824 | molecular_function | catalytic activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0006558 | biological_process | L-phenylalanine metabolic process |
C | 0006559 | biological_process | L-phenylalanine catabolic process |
C | 0009698 | biological_process | phenylpropanoid metabolic process |
C | 0009800 | biological_process | cinnamic acid biosynthetic process |
C | 0009820 | biological_process | alkaloid metabolic process |
C | 0009821 | biological_process | alkaloid biosynthetic process |
C | 0016829 | molecular_function | lyase activity |
C | 0016841 | molecular_function | ammonia-lyase activity |
C | 0016853 | molecular_function | isomerase activity |
C | 0016869 | molecular_function | intramolecular aminotransferase activity |
C | 0042617 | biological_process | paclitaxel biosynthetic process |
C | 0045548 | molecular_function | phenylalanine ammonia-lyase activity |
C | 0051289 | biological_process | protein homotetramerization |
D | 0003824 | molecular_function | catalytic activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0006558 | biological_process | L-phenylalanine metabolic process |
D | 0006559 | biological_process | L-phenylalanine catabolic process |
D | 0009698 | biological_process | phenylpropanoid metabolic process |
D | 0009800 | biological_process | cinnamic acid biosynthetic process |
D | 0009820 | biological_process | alkaloid metabolic process |
D | 0009821 | biological_process | alkaloid biosynthetic process |
D | 0016829 | molecular_function | lyase activity |
D | 0016841 | molecular_function | ammonia-lyase activity |
D | 0016853 | molecular_function | isomerase activity |
D | 0016869 | molecular_function | intramolecular aminotransferase activity |
D | 0042617 | biological_process | paclitaxel biosynthetic process |
D | 0045548 | molecular_function | phenylalanine ammonia-lyase activity |
D | 0051289 | biological_process | protein homotetramerization |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE TCA C 1679 |
Chain | Residue |
C | GLY87 |
C | HOH2074 |
C | HOH2173 |
D | GLN319 |
D | ARG325 |
C | MDO175 |
C | LEU179 |
C | ASN231 |
C | ASN355 |
C | PHE371 |
C | GLU455 |
C | TCA1681 |
C | HOH2032 |
site_id | AC2 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE TCA A 1679 |
Chain | Residue |
A | GLY87 |
A | LEU104 |
A | MDO175 |
A | LEU179 |
A | ASN231 |
A | ASN355 |
A | PHE371 |
A | GLU455 |
A | TCA1680 |
A | HOH2033 |
A | HOH2078 |
A | HOH2198 |
B | GLN319 |
B | ARG325 |
site_id | AC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE TCA A 1680 |
Chain | Residue |
A | GLY87 |
A | LEU104 |
A | MDO175 |
A | LEU179 |
A | LEU227 |
A | PHE371 |
A | ASN458 |
A | TCA1679 |
A | HOH2078 |
A | HOH2198 |
B | GLN319 |
B | TYR322 |
B | ARG325 |
site_id | AC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE TCA B 1679 |
Chain | Residue |
A | GLN319 |
A | TYR322 |
A | ARG325 |
A | HOH2121 |
B | GLY87 |
B | LEU104 |
B | MDO175 |
B | LEU179 |
B | PHE371 |
B | ASN458 |
B | TCA1680 |
B | HOH2078 |
site_id | AC5 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE TCA B 1680 |
Chain | Residue |
A | GLN319 |
A | ARG325 |
A | HOH2115 |
A | HOH2121 |
B | GLY87 |
B | MDO175 |
B | LEU179 |
B | ASN231 |
B | ASN355 |
B | PHE371 |
B | GLU455 |
B | TCA1679 |
B | HOH2078 |
site_id | AC6 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE TCA C 1681 |
Chain | Residue |
C | GLY87 |
C | LEU104 |
C | MDO175 |
C | LEU179 |
C | PHE371 |
C | GLU455 |
C | ASN458 |
C | TCA1679 |
C | HOH2074 |
C | HOH2173 |
D | GLN319 |
D | TYR322 |
D | ARG325 |
site_id | AC7 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE TCA D 1679 |
Chain | Residue |
C | GLN319 |
C | ARG325 |
C | HOH2113 |
C | HOH2117 |
D | GLY87 |
D | MDO175 |
D | LEU179 |
D | ASN231 |
D | ASN355 |
D | PHE371 |
D | GLU455 |
D | TCA1680 |
D | HOH2077 |
site_id | AC8 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE TCA D 1680 |
Chain | Residue |
D | PHE371 |
D | ASN458 |
D | TCA1679 |
D | HOH2077 |
C | GLN319 |
C | TYR322 |
C | ARG325 |
C | HOH2117 |
D | GLY87 |
D | LEU104 |
D | MDO175 |
D | LEU179 |
site_id | AC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO D 1681 |
Chain | Residue |
B | ARG106 |
B | CYS107 |
B | HOH2039 |
D | ASP423 |
D | GLY425 |
D | SER642 |
D | ALA643 |
site_id | BC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL B 1681 |
Chain | Residue |
B | ASP423 |
B | GLY425 |
B | SER642 |
B | ALA643 |
B | HOH2151 |
D | CYS107 |
Functional Information from PROSITE/UniProt
site_id | PS00488 |
Number of Residues | 17 |
Details | PAL_HISTIDASE Phenylalanine and histidine ammonia-lyases signature. GSVSASGDLiPLAyiaG |
Chain | Residue | Details |
A | GLY171-LEU189 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:22113970, ECO:0000269|PubMed:24786474 |
Chain | Residue | Details |
A | ALA80 | |
B | ALA80 | |
C | ALA80 | |
D | ALA80 |
site_id | SWS_FT_FI2 |
Number of Residues | 20 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24786474, ECO:0007744|PDB:4CQ5 |
Chain | Residue | Details |
A | THR233 | |
A | ARG321 | |
A | SER327 | |
A | ILE357 | |
A | ASP460 | |
B | THR233 | |
B | ARG321 | |
B | SER327 | |
B | ILE357 | |
B | ASP460 | |
C | THR233 | |
C | ARG321 | |
C | SER327 | |
C | ILE357 | |
C | ASP460 | |
D | THR233 | |
D | ARG321 | |
D | SER327 | |
D | ILE357 | |
D | ASP460 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P11544 |
Chain | Residue | Details |
C | LEU429 | |
C | HIS457 | |
D | LEU429 | |
D | HIS457 | |
A | LEU429 | |
A | HIS457 | |
B | LEU429 | |
B | HIS457 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | MOD_RES: 2,3-didehydroalanine (Ser) => ECO:0000269|PubMed:24786474 |
Chain | Residue | Details |
A | ASP178 | |
B | ASP178 | |
C | ASP178 | |
D | ASP178 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | CROSSLNK: 5-imidazolinone (Ala-Gly) => ECO:0000269|PubMed:24786474 |
Chain | Residue | Details |
A | MDO175 | |
A | LEU179 | |
B | MDO175 | |
B | LEU179 | |
C | MDO175 | |
C | LEU179 | |
D | MDO175 | |
D | LEU179 |