4C3O
Structure and function of an oxygen tolerant NiFe hydrogenase from Salmonella
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| A | 0016151 | molecular_function | nickel cation binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0033748 | molecular_function | hydrogenase (acceptor) activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| B | 0009375 | cellular_component | ferredoxin hydrogenase complex |
| B | 0051536 | molecular_function | iron-sulfur cluster binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| C | 0016151 | molecular_function | nickel cation binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0033748 | molecular_function | hydrogenase (acceptor) activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| D | 0009375 | cellular_component | ferredoxin hydrogenase complex |
| D | 0051536 | molecular_function | iron-sulfur cluster binding |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| E | 0016151 | molecular_function | nickel cation binding |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0033748 | molecular_function | hydrogenase (acceptor) activity |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| F | 0009375 | cellular_component | ferredoxin hydrogenase complex |
| F | 0051536 | molecular_function | iron-sulfur cluster binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue NFU A 1004 |
| Chain | Residue |
| A | CYS76 |
| A | PRO534 |
| A | THR535 |
| A | CYS579 |
| A | CYS582 |
| A | CYS79 |
| A | THR82 |
| A | HIS83 |
| A | ALA510 |
| A | PRO511 |
| A | ARG512 |
| A | LEU515 |
| A | VAL533 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 1586 |
| Chain | Residue |
| A | ARG169 |
| A | ARG172 |
| B | SER38 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 1587 |
| Chain | Residue |
| A | ARG323 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 1588 |
| Chain | Residue |
| A | LYS266 |
| C | LYS214 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 1590 |
| Chain | Residue |
| A | LYS214 |
| C | LYS266 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 1005 |
| Chain | Residue |
| A | GLU57 |
| A | GLU347 |
| A | LYS402 |
| A | GLN530 |
| A | CYS531 |
| A | HIS585 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue SF4 B 1001 |
| Chain | Residue |
| B | HIS187 |
| B | CYS190 |
| B | ARG193 |
| B | PHE196 |
| B | CYS215 |
| B | LEU216 |
| B | CYS221 |
| B | ILE243 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for residue F3S B 1002 |
| Chain | Residue |
| A | LYS226 |
| B | ILE186 |
| B | ASN228 |
| B | CYS230 |
| B | TRP235 |
| B | PRO242 |
| B | CYS249 |
| B | LEU250 |
| B | CYS252 |
| B | HOH2007 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue F4S B 1003 |
| Chain | Residue |
| A | HIS229 |
| B | CYS17 |
| B | THR18 |
| B | CYS19 |
| B | CYS20 |
| B | SER114 |
| B | CYS115 |
| B | CYS120 |
| B | CYS149 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 1267 |
| Chain | Residue |
| B | ASP173 |
| B | ARG174 |
| B | LYS179 |
| site_id | AD2 |
| Number of Residues | 12 |
| Details | binding site for residue NFU C 1004 |
| Chain | Residue |
| C | CYS76 |
| C | CYS79 |
| C | HIS83 |
| C | ALA510 |
| C | PRO511 |
| C | ARG512 |
| C | LEU515 |
| C | VAL533 |
| C | PRO534 |
| C | THR535 |
| C | CYS579 |
| C | CYS582 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue MG C 1586 |
| Chain | Residue |
| C | GLU57 |
| C | GLU347 |
| C | LYS402 |
| C | GLN530 |
| C | CYS531 |
| C | HIS585 |
| C | HOH2019 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue SF4 D 1001 |
| Chain | Residue |
| D | HIS187 |
| D | CYS190 |
| D | ARG193 |
| D | CYS215 |
| D | LEU216 |
| D | TYR217 |
| D | CYS221 |
| D | ILE243 |
| site_id | AD5 |
| Number of Residues | 9 |
| Details | binding site for residue F3S D 1002 |
| Chain | Residue |
| C | LYS226 |
| D | ILE186 |
| D | ASN228 |
| D | CYS230 |
| D | TRP235 |
| D | PRO242 |
| D | CYS249 |
| D | LEU250 |
| D | CYS252 |
| site_id | AD6 |
| Number of Residues | 10 |
| Details | binding site for residue F4S D 1003 |
| Chain | Residue |
| D | GLU76 |
| D | CYS115 |
| D | CYS120 |
| D | CYS149 |
| C | HIS229 |
| D | GLU16 |
| D | CYS17 |
| D | THR18 |
| D | CYS19 |
| D | CYS20 |
| site_id | AD7 |
| Number of Residues | 13 |
| Details | binding site for residue NFU E 1004 |
| Chain | Residue |
| E | CYS76 |
| E | CYS79 |
| E | THR82 |
| E | HIS83 |
| E | ALA510 |
| E | PRO511 |
| E | ARG512 |
| E | LEU515 |
| E | VAL533 |
| E | PRO534 |
| E | THR535 |
| E | CYS579 |
| E | CYS582 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue CL E 1586 |
| Chain | Residue |
| E | ARG172 |
| F | SER38 |
| site_id | AD9 |
| Number of Residues | 1 |
| Details | binding site for residue CL E 1587 |
| Chain | Residue |
| E | LYS214 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue MG E 1005 |
| Chain | Residue |
| E | GLU57 |
| E | GLU347 |
| E | CYS531 |
| E | HIS585 |
| E | HOH2027 |
| site_id | AE2 |
| Number of Residues | 9 |
| Details | binding site for residue F4S F 1003 |
| Chain | Residue |
| E | HIS229 |
| F | CYS17 |
| F | THR18 |
| F | CYS19 |
| F | CYS20 |
| F | GLU76 |
| F | CYS115 |
| F | CYS120 |
| F | CYS149 |
| site_id | AE3 |
| Number of Residues | 8 |
| Details | binding site for residue SF4 F 1001 |
| Chain | Residue |
| F | HIS187 |
| F | CYS190 |
| F | ARG193 |
| F | CYS215 |
| F | LEU216 |
| F | TYR217 |
| F | CYS221 |
| F | ILE243 |
| site_id | AE4 |
| Number of Residues | 8 |
| Details | binding site for residue F3S F 1002 |
| Chain | Residue |
| E | HOH2016 |
| F | ILE186 |
| F | CYS230 |
| F | TRP235 |
| F | PRO242 |
| F | CYS249 |
| F | LEU250 |
| F | CYS252 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 F 1268 |
| Chain | Residue |
| F | ASP173 |
| F | ARG174 |
| F | LYS179 |
Functional Information from PROSITE/UniProt
| site_id | PS00507 |
| Number of Residues | 26 |
| Details | NI_HGENASE_L_1 Nickel-dependent hydrogenases large subunit signature 1. RGLEvilkgrdprdawafvERiCGVC |
| Chain | Residue | Details |
| A | ARG54-CYS79 |
| site_id | PS00508 |
| Number of Residues | 10 |
| Details | NI_HGENASE_L_2 Nickel-dependent hydrogenases large subunit signature 2. FDPCLACst.H |
| Chain | Residue | Details |
| A | PHE576-HIS585 |
