4B0I

Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) mutant (H70N) from Pseudomonas aeruginosa in complex with 3-hydroxydecanoyl-N-acetyl cysteamine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006633	biological_process	fatty acid biosynthetic process
A	0006636	biological_process	unsaturated fatty acid biosynthetic process
A	0008693	molecular_function	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
A	0016829	molecular_function	lyase activity
A	0016853	molecular_function	isomerase activity
A	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
A	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity
B	0005737	cellular_component	cytoplasm
B	0006633	biological_process	fatty acid biosynthetic process
B	0006636	biological_process	unsaturated fatty acid biosynthetic process
B	0008693	molecular_function	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
B	0016829	molecular_function	lyase activity
B	0016853	molecular_function	isomerase activity
B	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
B	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity
C	0005737	cellular_component	cytoplasm
C	0006633	biological_process	fatty acid biosynthetic process
C	0006636	biological_process	unsaturated fatty acid biosynthetic process
C	0008693	molecular_function	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
C	0016829	molecular_function	lyase activity
C	0016853	molecular_function	isomerase activity
C	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
C	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity
D	0005737	cellular_component	cytoplasm
D	0006633	biological_process	fatty acid biosynthetic process
D	0006636	biological_process	unsaturated fatty acid biosynthetic process
D	0008693	molecular_function	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
D	0016829	molecular_function	lyase activity
D	0016853	molecular_function	isomerase activity
D	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
D	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity
E	0005737	cellular_component	cytoplasm
E	0006633	biological_process	fatty acid biosynthetic process
E	0006636	biological_process	unsaturated fatty acid biosynthetic process
E	0008693	molecular_function	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
E	0016829	molecular_function	lyase activity
E	0016853	molecular_function	isomerase activity
E	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
E	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE KBP A 1170

Chain	Residue
A	GLN27
A	HOH2046
A	HOH2047
A	HOH2085
B	MET77
B	PRO78
B	GLY79
B	GLY115
B	GLN116
A	LEU28
A	ASP84
A	TRP87
A	GLN88
A	GLY91
A	PHE92
A	ARG104
A	ALA105

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE KBP B 1172

Chain	Residue
A	PHE71
A	MET77
A	PRO78
A	GLY79
A	GLY115
A	GLN116
A	HOH2043
A	HOH2045
B	GLN27
B	ASP84
B	GLN88
B	GLY91
B	PHE92
B	ARG104
B	ALA105
B	PHE171

---

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE KBP C 1172

Chain	Residue
C	GLN27
C	LEU28
C	ASP84
C	TRP87
C	GLN88
C	GLY91
C	PHE92
C	ARG104
C	ALA105
C	PHE171
C	HOH2061
C	HOH2091
D	ASN70
D	MET77
D	PRO78
D	GLY79
D	GLY115
D	GLN116

---

site_id	AC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE KBP D 1172

Chain	Residue
C	ASN70
C	PHE71
C	PRO78
C	GLY79
C	GLY115
C	GLN116
C	HOH2052
C	HOH2058
C	HOH2060
D	GLN27
D	LEU28
D	ASP84
D	TRP87
D	GLN88
D	GLY91
D	PHE92
D	ARG104
D	ALA105
D	PHE171

---

site_id	AC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE KBP E 1172

Chain	Residue
E	ALA26
E	GLN27
E	LEU28
E	ASN70
E	PHE71
E	MET77
E	PRO78
E	GLY79
E	ASP84
E	GLN88
E	GLY91
E	PHE92
E	ARG104
E	ALA105
E	GLY115
E	GLN116
E	PHE171
E	HOH2024
E	HOH2027
E	HOH2028

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	ASN70
B	ASN70
C	ASN70
D	ASN70
E	ASN70

---