Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4AS5

Structure of mouse inositol monophosphatase 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005737	cellular_component	cytoplasm
A	0006020	biological_process	inositol metabolic process
A	0006021	biological_process	inositol biosynthetic process
A	0006661	biological_process	phosphatidylinositol biosynthetic process
A	0007165	biological_process	signal transduction
A	0008934	molecular_function	inositol monophosphate 1-phosphatase activity
A	0016787	molecular_function	hydrolase activity
A	0030145	molecular_function	manganese ion binding
A	0030424	cellular_component	axon
A	0031403	molecular_function	lithium ion binding
A	0042803	molecular_function	protein homodimerization activity
A	0043025	cellular_component	neuronal cell body
A	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0052832	molecular_function	inositol monophosphate 3-phosphatase activity
A	0052833	molecular_function	inositol monophosphate 4-phosphatase activity
A	0052834	molecular_function	inositol monophosphate phosphatase activity
B	0000287	molecular_function	magnesium ion binding
B	0005737	cellular_component	cytoplasm
B	0006020	biological_process	inositol metabolic process
B	0006021	biological_process	inositol biosynthetic process
B	0006661	biological_process	phosphatidylinositol biosynthetic process
B	0007165	biological_process	signal transduction
B	0008934	molecular_function	inositol monophosphate 1-phosphatase activity
B	0016787	molecular_function	hydrolase activity
B	0030145	molecular_function	manganese ion binding
B	0030424	cellular_component	axon
B	0031403	molecular_function	lithium ion binding
B	0042803	molecular_function	protein homodimerization activity
B	0043025	cellular_component	neuronal cell body
B	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0052832	molecular_function	inositol monophosphate 3-phosphatase activity
B	0052833	molecular_function	inositol monophosphate 4-phosphatase activity
B	0052834	molecular_function	inositol monophosphate phosphatase activity
C	0000287	molecular_function	magnesium ion binding
C	0005737	cellular_component	cytoplasm
C	0006020	biological_process	inositol metabolic process
C	0006021	biological_process	inositol biosynthetic process
C	0006661	biological_process	phosphatidylinositol biosynthetic process
C	0007165	biological_process	signal transduction
C	0008934	molecular_function	inositol monophosphate 1-phosphatase activity
C	0016787	molecular_function	hydrolase activity
C	0030145	molecular_function	manganese ion binding
C	0030424	cellular_component	axon
C	0031403	molecular_function	lithium ion binding
C	0042803	molecular_function	protein homodimerization activity
C	0043025	cellular_component	neuronal cell body
C	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
C	0046872	molecular_function	metal ion binding
C	0052832	molecular_function	inositol monophosphate 3-phosphatase activity
C	0052833	molecular_function	inositol monophosphate 4-phosphatase activity
C	0052834	molecular_function	inositol monophosphate phosphatase activity
D	0000287	molecular_function	magnesium ion binding
D	0005737	cellular_component	cytoplasm
D	0006020	biological_process	inositol metabolic process
D	0006021	biological_process	inositol biosynthetic process
D	0006661	biological_process	phosphatidylinositol biosynthetic process
D	0007165	biological_process	signal transduction
D	0008934	molecular_function	inositol monophosphate 1-phosphatase activity
D	0016787	molecular_function	hydrolase activity
D	0030145	molecular_function	manganese ion binding
D	0030424	cellular_component	axon
D	0031403	molecular_function	lithium ion binding
D	0042803	molecular_function	protein homodimerization activity
D	0043025	cellular_component	neuronal cell body
D	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
D	0046872	molecular_function	metal ion binding
D	0052832	molecular_function	inositol monophosphate 3-phosphatase activity
D	0052833	molecular_function	inositol monophosphate 4-phosphatase activity
D	0052834	molecular_function	inositol monophosphate phosphatase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE PO4 A 401

Chain	Residue
A	GLU70
A	MG503
A	HOH2043
A	HOH2050
A	HOH2053
A	HOH2091
A	HOH2092
A	HOH2112
A	HOH2113
A	ASP90
A	ILE92
A	ASP93
A	GLY94
A	THR95
A	ASP220
A	MG501
A	MG502

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 501

Chain	Residue
A	GLU70
A	ASP90
A	ILE92
A	PO4401
A	MG502
A	HOH2055
A	HOH2091

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 502

Chain	Residue
A	ASP90
A	ASP93
A	ASP220
A	PO4401
A	MG501

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 503

Chain	Residue
A	LEU42
A	GLU70
A	PO4401
A	HOH2043
A	HOH2052
A	HOH2053
A	HOH2091

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1279

Chain	Residue
A	ASP10
A	ILE14
A	HOH2238
C	PHE140
C	GLY143

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1280

Chain	Residue
A	MET22
A	THR46
A	LYS49
A	HOH2239

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1281

Chain	Residue
A	CYS64
A	HOH2240

site_id	AC8
Number of Residues	17
Details	BINDING SITE FOR RESIDUE PO4 B 401

Chain	Residue
B	GLU70
B	ASP90
B	ILE92
B	ASP93
B	GLY94
B	THR95
B	ASP220
B	MG501
B	MG502
B	MG503
B	GOL1279
B	HOH2050
B	HOH2058
B	HOH2059
B	HOH2063
B	HOH2088
B	HOH2114

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG B 501

Chain	Residue
B	GLU70
B	ASP90
B	ILE92
B	PO4401
B	MG503
B	HOH2062
B	HOH2063

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 502

Chain	Residue
B	ASP90
B	ASP93
B	ASP220
B	PO4401

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG B 503

Chain	Residue
B	GLU70
B	PO4401
B	MG501
B	HOH2049
B	HOH2050
B	HOH2058
B	HOH2063

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD B 1278

Chain	Residue
B	CYS64

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 1279

Chain	Residue
B	ASP93
B	GLY164
B	THR195
B	ALA196
B	GLU213
B	ILE216
B	PO4401

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL B 1280

Chain	Residue
B	VAL13
B	ILE14
B	ARG17
B	HOH2012
B	HOH2235
D	GLY143
D	GLN144
D	LYS145

site_id	BC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE PO4 C 401

Chain	Residue
C	ASP90
C	ILE92
C	ASP93
C	GLY94
C	THR95
C	ASP220
C	MG501
C	MG502
C	MG503
C	HOH2026
C	HOH2032
C	HOH2033
C	HOH2058
C	HOH2081
C	HOH2083
C	GLU70

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 501

Chain	Residue
C	GLU70
C	ASP90
C	ILE92
C	PO4401
C	MG503
C	HOH2038

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 502

Chain	Residue
C	ASP90
C	ASP93
C	ASP220
C	PO4401

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 503

Chain	Residue
C	GLU70
C	PO4401
C	MG501
C	HOH2026
C	HOH2033
C	HOH2034

site_id	CC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD C 1278

Chain	Residue
C	CYS64

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 1279

Chain	Residue
C	PHE104
C	GLU127
C	LYS129
C	TYR131

site_id	CC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE PO4 D 401

Chain	Residue
D	GLU70
D	ASP90
D	ILE92
D	ASP93
D	GLY94
D	THR95
D	ASP220
D	MG501
D	MG502
D	MG503
D	HOH2029
D	HOH2033
D	HOH2034
D	HOH2040
D	HOH2059
D	HOH2075
D	HOH2134
D	HOH2143

site_id	CC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG D 501

Chain	Residue
D	GLU70
D	ASP90
D	ILE92
D	PO4401
D	MG502
D	HOH2040
D	HOH2041

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 502

Chain	Residue
D	ASP90
D	ASP93
D	ASP220
D	PO4401
D	MG501

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 503

Chain	Residue
D	GLU70
D	PO4401
D	HOH2028
D	HOH2029
D	HOH2033
D	HOH2040

site_id	CC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD D 1278

Chain	Residue
D	CYS64

site_id	CC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD D 1279

Chain	Residue
D	HOH2042

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO D 1280

Chain	Residue
C	PRO103
D	GLU127
D	LYS129
D	TYR131
D	VAL198
D	LEU202

Functional Information from PROSITE/UniProt

site_id	PS00629
Number of Residues	14
Details	IMP_1 Inositol monophosphatase family signature 1. WvIDPIDGTtnFvH

Chain	Residue	Details
A	TRP87-HIS100

site_id	PS00630
Number of Residues	15
Details	IMP_2 Inositol monophosphatase family signature 2. WDmAGAgIIVteaGG

Chain	Residue	Details
A	TRP219-GLY233

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	GLU70
B	GLU70
C	GLU70
D	GLU70

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:23027737

Chain	Residue	Details
A	ASP90
D	ASP90
D	ILE92
D	ASP93
A	ILE92
A	ASP93
B	ASP90
B	ILE92
B	ASP93
C	ASP90
C	ILE92
C	ASP93

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P29218

Chain	Residue	Details
A	GLY194
D	GLY194
D	GLU213
D	ASP220
A	GLU213
A	ASP220
B	GLY194
B	GLU213
B	ASP220
C	GLY194
C	GLU213
C	ASP220

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)