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4AQH

Plasminogen activator inhibitor type-1 in complex with the inhibitor AZ3976

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0002020molecular_functionprotease binding
A0004867molecular_functionserine-type endopeptidase inhibitor activity
A0005102molecular_functionsignaling receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005886cellular_componentplasma membrane
A0010469biological_processregulation of signaling receptor activity
A0010757biological_processnegative regulation of plasminogen activation
A0010951biological_processnegative regulation of endopeptidase activity
A0014912biological_processnegative regulation of smooth muscle cell migration
A0030194biological_processpositive regulation of blood coagulation
A0030195biological_processnegative regulation of blood coagulation
A0030336biological_processnegative regulation of cell migration
A0031093cellular_componentplatelet alpha granule lumen
A0032757biological_processpositive regulation of interleukin-8 production
A0033629biological_processnegative regulation of cell adhesion mediated by integrin
A0035491biological_processpositive regulation of leukotriene production involved in inflammatory response
A0042730biological_processfibrinolysis
A0045766biological_processpositive regulation of angiogenesis
A0048260biological_processpositive regulation of receptor-mediated endocytosis
A0050729biological_processpositive regulation of inflammatory response
A0050829biological_processdefense response to Gram-negative bacterium
A0051918biological_processnegative regulation of fibrinolysis
A0061044biological_processnegative regulation of vascular wound healing
A0061045biological_processnegative regulation of wound healing
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0071222biological_processcellular response to lipopolysaccharide
A0090026biological_processpositive regulation of monocyte chemotaxis
A0090399biological_processreplicative senescence
A0097180cellular_componentserine protease inhibitor complex
A0097187biological_processdentinogenesis
A1901331biological_processpositive regulation of odontoblast differentiation
A1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
A1904090cellular_componentpeptidase inhibitor complex
A2000098biological_processnegative regulation of smooth muscle cell-matrix adhesion
A2000352biological_processnegative regulation of endothelial cell apoptotic process
B0001525biological_processangiogenesis
B0002020molecular_functionprotease binding
B0004867molecular_functionserine-type endopeptidase inhibitor activity
B0005102molecular_functionsignaling receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005886cellular_componentplasma membrane
B0010469biological_processregulation of signaling receptor activity
B0010757biological_processnegative regulation of plasminogen activation
B0010951biological_processnegative regulation of endopeptidase activity
B0014912biological_processnegative regulation of smooth muscle cell migration
B0030194biological_processpositive regulation of blood coagulation
B0030195biological_processnegative regulation of blood coagulation
B0030336biological_processnegative regulation of cell migration
B0031093cellular_componentplatelet alpha granule lumen
B0032757biological_processpositive regulation of interleukin-8 production
B0033629biological_processnegative regulation of cell adhesion mediated by integrin
B0035491biological_processpositive regulation of leukotriene production involved in inflammatory response
B0042730biological_processfibrinolysis
B0045766biological_processpositive regulation of angiogenesis
B0048260biological_processpositive regulation of receptor-mediated endocytosis
B0050729biological_processpositive regulation of inflammatory response
B0050829biological_processdefense response to Gram-negative bacterium
B0051918biological_processnegative regulation of fibrinolysis
B0061044biological_processnegative regulation of vascular wound healing
B0061045biological_processnegative regulation of wound healing
B0062023cellular_componentcollagen-containing extracellular matrix
B0070062cellular_componentextracellular exosome
B0071222biological_processcellular response to lipopolysaccharide
B0090026biological_processpositive regulation of monocyte chemotaxis
B0090399biological_processreplicative senescence
B0097180cellular_componentserine protease inhibitor complex
B0097187biological_processdentinogenesis
B1901331biological_processpositive regulation of odontoblast differentiation
B1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
B1904090cellular_componentpeptidase inhibitor complex
B2000098biological_processnegative regulation of smooth muscle cell-matrix adhesion
B2000352biological_processnegative regulation of endothelial cell apoptotic process
C0001525biological_processangiogenesis
C0002020molecular_functionprotease binding
C0004867molecular_functionserine-type endopeptidase inhibitor activity
C0005102molecular_functionsignaling receptor binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005886cellular_componentplasma membrane
C0010469biological_processregulation of signaling receptor activity
C0010757biological_processnegative regulation of plasminogen activation
C0010951biological_processnegative regulation of endopeptidase activity
C0014912biological_processnegative regulation of smooth muscle cell migration
C0030194biological_processpositive regulation of blood coagulation
C0030195biological_processnegative regulation of blood coagulation
C0030336biological_processnegative regulation of cell migration
C0031093cellular_componentplatelet alpha granule lumen
C0032757biological_processpositive regulation of interleukin-8 production
C0033629biological_processnegative regulation of cell adhesion mediated by integrin
C0035491biological_processpositive regulation of leukotriene production involved in inflammatory response
C0042730biological_processfibrinolysis
C0045766biological_processpositive regulation of angiogenesis
C0048260biological_processpositive regulation of receptor-mediated endocytosis
C0050729biological_processpositive regulation of inflammatory response
C0050829biological_processdefense response to Gram-negative bacterium
C0051918biological_processnegative regulation of fibrinolysis
C0061044biological_processnegative regulation of vascular wound healing
C0061045biological_processnegative regulation of wound healing
C0062023cellular_componentcollagen-containing extracellular matrix
C0070062cellular_componentextracellular exosome
C0071222biological_processcellular response to lipopolysaccharide
C0090026biological_processpositive regulation of monocyte chemotaxis
C0090399biological_processreplicative senescence
C0097180cellular_componentserine protease inhibitor complex
C0097187biological_processdentinogenesis
C1901331biological_processpositive regulation of odontoblast differentiation
C1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
C1904090cellular_componentpeptidase inhibitor complex
C2000098biological_processnegative regulation of smooth muscle cell-matrix adhesion
C2000352biological_processnegative regulation of endothelial cell apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE TB7 A 1380
ChainResidue
ATYR37
APHE117
AARG118
ASER41
AALA44
ALEU75
AARG76
ALEU78
ATYR79
ATHR94
AASP95

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE TB7 B 1380
ChainResidue
BTYR37
BSER41
BALA44
BARG76
BLEU78
BTYR79
BTHR94
BASP95
BPHE117
BARG118

site_idAC3
Number of Residues11
DetailsBINDING SITE FOR RESIDUE TB7 C 1380
ChainResidue
CTYR37
CSER41
CALA44
CARG76
CLEU78
CTYR79
CTHR94
CASP95
CLEU116
CPHE117
CARG118

Functional Information from PROSITE/UniProt
site_idPS00284
Number of Residues11
DetailsSERPIN Serpins signature. IIMDRPFLFvV
ChainResidueDetails
AILE352-VAL362

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsSITE: Reactive bond
ChainResidueDetails
AARG346
BARG346
CARG346

site_idSWS_FT_FI2
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine
ChainResidueDetails
AASN209
AASN265
BASN209
BASN265
CASN209
CASN265

site_idSWS_FT_FI3
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN329
BASN329
CASN329

219140

PDB entries from 2024-05-01

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