4AJX

Ligand controlled assembly of hexamers, dihexamers, and linear multihexamer structures by an engineered acylated insulin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005179	molecular_function	hormone activity
A	0005576	cellular_component	extracellular region
B	0005179	molecular_function	hormone activity
B	0005576	cellular_component	extracellular region
C	0005179	molecular_function	hormone activity
C	0005576	cellular_component	extracellular region
D	0005179	molecular_function	hormone activity
D	0005576	cellular_component	extracellular region
E	0005179	molecular_function	hormone activity
E	0005576	cellular_component	extracellular region
F	0005179	molecular_function	hormone activity
F	0005576	cellular_component	extracellular region
G	0005179	molecular_function	hormone activity
G	0005576	cellular_component	extracellular region
H	0005179	molecular_function	hormone activity
H	0005576	cellular_component	extracellular region
I	0005179	molecular_function	hormone activity
I	0005576	cellular_component	extracellular region
J	0005179	molecular_function	hormone activity
J	0005576	cellular_component	extracellular region
K	0005179	molecular_function	hormone activity
K	0005576	cellular_component	extracellular region
L	0005179	molecular_function	hormone activity
L	0005576	cellular_component	extracellular region

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 16E A 1022

Chain	Residue
A	GLN15
B	NA1031
C	TYR14
C	GLU17
D	VAL18
D	GLY20
D	GLU21
D	ARG22
E	TYR14
A	ASN18
A	HOH2006
A	HOH2049
A	HOH2050
A	HOH2051
A	HOH2052
A	HOH2053
B	LYS29

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE RCO B 1030

Chain	Residue
A	CYS6
A	ILE10
A	CYS11
A	HOH2034
B	LEU11
B	ALA14
B	HOH2018
F	HIS5

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA B 1031

Chain	Residue
A	16E1022
A	HOH2004
A	HOH2013
B	LYS29
B	HOH2037
D	ARG22

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO D 1029

Chain	Residue
C	CYS6
C	SER9
C	ILE10
C	CYS11
C	HOH2020
D	LEU11
D	ALA14
D	HOH2023
J	HIS5

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IMD D 1030

Chain	Residue
D	GLU13
H	GLU13
J	GLU13
L	GLU13

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE RCO E 1022

Chain	Residue
D	LEU17
E	CYS6
E	SER9
E	ILE10
E	CYS11
E	HOH2012
F	LEU11
L	HIS5

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 1029

Chain	Residue
B	HIS10
F	HIS10
L	HIS10
L	IMD1031

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE RCO G 1022

Chain	Residue
D	HIS5
G	CYS6
G	ILE10
G	CYS11
G	HOH2025
H	ALA14
L	LEU17

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 1030

Chain	Residue
D	HIS10
H	HIS10
H	16E1031
J	HIS10

---

site_id	BC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 16E H 1031

Chain	Residue
D	ASN3
D	LEU6
D	HIS10
D	HOH2007
G	VAL3
G	GLU4
G	CYS7
H	ASN3
H	GLN4
H	HIS10
H	ZN1030
J	LEU6
J	HIS10

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA H 1032

Chain	Residue
B	SER9
B	HOH2016
H	GLU13
H	TYR16
H	LEU17
L	GLU13

---

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE RCO J 1029

Chain	Residue
H	HIS5
I	CYS6
I	ILE10
I	CYS11
I	HOH2012
J	LEU11
J	ALA14

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IMD K 1022

Chain	Residue
K	GLN5
K	CYS11
K	TYR19
K	HOH2022

---

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE RCO L 1030

Chain	Residue
K	ILE10
K	CYS11
K	HOH2018
L	LEU11
L	ALA14
L	HOH2003
B	HIS5
K	CYS6

---

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IMD L 1031

Chain	Residue
B	HIS10
F	LEU6
F	HIS10
F	ZN1029
F	HOH2003
L	LEU6
L	HIS10

---

Functional Information from PROSITE/UniProt

site_id	PS00262
Number of Residues	15
Details	INSULIN Insulin family signature. CCTSiCSlyqLenyC

Chain	Residue	Details
A	CYS6-CYS20

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