4AFX

Crystal structure of the reactive loop cleaved ZPI in I2 space group

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004867	molecular_function	serine-type endopeptidase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0007596	biological_process	blood coagulation
A	0007599	biological_process	hemostasis
A	0008201	molecular_function	heparin binding
A	0030414	molecular_function	peptidase inhibitor activity
A	0060046	biological_process	regulation of acrosome reaction
A	0070062	cellular_component	extracellular exosome
A	0097421	biological_process	liver regeneration

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA A 1387

Chain	Residue
A	GLU292

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA A 1388

Chain	Residue
A	ASN159
A	ARG163

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 A 1389

Chain	Residue
A	SER64
A	ARG67

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site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 A 1390

Chain	Residue
A	LEU120
A	PRO121
A	GLU100
A	LYS104
A	PRO117
A	GLY118

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site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA A 1391

Chain	Residue
A	GLN102

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site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 A 1392

Chain	Residue
A	HIS73
A	GLY75
A	ASN76
A	GLN323

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Essential for interaction with PROZ => ECO:0000250

Chain	Residue	Details
A	TYR240
A	ASP293

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Reactive bond => ECO:0000250

Chain	Residue	Details
A	ARG387

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039

Chain	Residue	Details
A	SER35

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ASN15

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952

Chain	Residue	Details
A	ASN159

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20427285

Chain	Residue	Details
A	ASN176

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site_id	SWS_FT_FI7
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:20427285

Chain	Residue	Details
A	ASN274

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