4AFS

Human Chymase - Fynomer Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002003	biological_process	angiotensin maturation
A	0004175	molecular_function	endopeptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006508	biological_process	proteolysis
A	0006518	biological_process	peptide metabolic process
A	0008236	molecular_function	serine-type peptidase activity
A	0016485	biological_process	protein processing
A	0022617	biological_process	extracellular matrix disassembly
A	0030141	cellular_component	secretory granule
A	0030163	biological_process	protein catabolic process
A	0030901	biological_process	midbrain development
A	0034769	biological_process	basement membrane disassembly
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0042277	molecular_function	peptide binding
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0045766	biological_process	positive regulation of angiogenesis
A	0050727	biological_process	regulation of inflammatory response
A	0062023	cellular_component	collagen-containing extracellular matrix
A	0071333	biological_process	cellular response to glucose stimulus
A	0140447	biological_process	cytokine precursor processing

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1227

Chain	Residue
A	HIS10
A	GLU64
A	HOH2019
C	HIS22

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 A 1228

Chain	Residue
A	HOH2092
A	HOH2152
A	HOH2152
A	HOH2153
A	ARG124
A	ARG124
A	ALA189
A	GLY190
A	HOH2092

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site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 A 1229

Chain	Residue
A	PHE29
A	HIS45
A	LYS179
A	GLY180
A	SER182
A	HOH2131
A	HOH2154
C	TRP16

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site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1230

Chain	Residue
A	ASN115
A	ASN115
A	ARG121
A	ARG121
A	GLN193
A	HOH2133
A	HOH2133

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site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 A 1231

Chain	Residue
A	ARG124
A	LYS145

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU41-CYS46

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. SAfkGDSGGPLL

Chain	Residue	Details
A	SER176-LEU187

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
A	HIS45
A	ASP89
A	SER182

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:2071582

Chain	Residue	Details
A	ASN59

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ASN82

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