4A97
X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with zopiclone
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0016020 | cellular_component | membrane |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
| F | 0004888 | molecular_function | transmembrane signaling receptor activity |
| F | 0005216 | molecular_function | monoatomic ion channel activity |
| F | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| F | 0006811 | biological_process | monoatomic ion transport |
| F | 0016020 | cellular_component | membrane |
| F | 0034220 | biological_process | monoatomic ion transmembrane transport |
| G | 0004888 | molecular_function | transmembrane signaling receptor activity |
| G | 0005216 | molecular_function | monoatomic ion channel activity |
| G | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| G | 0006811 | biological_process | monoatomic ion transport |
| G | 0016020 | cellular_component | membrane |
| G | 0034220 | biological_process | monoatomic ion transmembrane transport |
| H | 0004888 | molecular_function | transmembrane signaling receptor activity |
| H | 0005216 | molecular_function | monoatomic ion channel activity |
| H | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| H | 0006811 | biological_process | monoatomic ion transport |
| H | 0016020 | cellular_component | membrane |
| H | 0034220 | biological_process | monoatomic ion transmembrane transport |
| I | 0004888 | molecular_function | transmembrane signaling receptor activity |
| I | 0005216 | molecular_function | monoatomic ion channel activity |
| I | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| I | 0006811 | biological_process | monoatomic ion transport |
| I | 0016020 | cellular_component | membrane |
| I | 0034220 | biological_process | monoatomic ion transmembrane transport |
| J | 0004888 | molecular_function | transmembrane signaling receptor activity |
| J | 0005216 | molecular_function | monoatomic ion channel activity |
| J | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| J | 0006811 | biological_process | monoatomic ion transport |
| J | 0016020 | cellular_component | membrane |
| J | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ZPC A 1318 |
| Chain | Residue |
| A | GLU77 |
| E | GLU150 |
| A | GLU131 |
| A | PRO132 |
| A | PHE133 |
| A | TYR175 |
| A | HIS177 |
| E | TYR38 |
| E | VAL40 |
| E | ARG91 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ZPC B 1318 |
| Chain | Residue |
| A | PHE19 |
| A | TYR38 |
| A | ARG91 |
| A | ILE101 |
| A | ASN103 |
| A | GLU150 |
| B | GLU77 |
| B | GLU131 |
| B | PRO132 |
| B | PHE133 |
| B | TYR175 |
| B | HIS177 |
| B | PHE188 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ZPC C 1318 |
| Chain | Residue |
| B | PHE19 |
| B | VAL40 |
| B | ARG91 |
| B | ASN103 |
| B | GLU150 |
| C | GLU77 |
| C | GLU131 |
| C | PRO132 |
| C | PHE133 |
| C | TYR175 |
| C | HIS177 |
| C | VAL181 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ZPC D 1318 |
| Chain | Residue |
| C | PHE19 |
| C | TYR38 |
| C | ARG91 |
| C | ILE101 |
| C | ASN103 |
| C | GLU150 |
| D | GLU77 |
| D | PRO132 |
| D | PHE133 |
| D | TYR175 |
| D | HIS177 |
| D | LEU178 |
| D | VAL181 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ZPC E 1318 |
| Chain | Residue |
| D | PHE19 |
| D | TYR38 |
| D | VAL40 |
| D | ARG91 |
| D | MET93 |
| D | ILE101 |
| D | ASN103 |
| D | GLU150 |
| E | PRO132 |
| E | PHE133 |
| E | TYR175 |
| E | HIS177 |
| E | VAL181 |
| E | PHE188 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ZPC F 1318 |
| Chain | Residue |
| F | GLU77 |
| F | GLU131 |
| F | PRO132 |
| F | PHE133 |
| F | TYR175 |
| F | HIS177 |
| F | PHE188 |
| J | PHE19 |
| J | ARG91 |
| J | ILE101 |
| J | ASN103 |
| J | GLU150 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ZPC G 1318 |
| Chain | Residue |
| F | PHE19 |
| F | TYR38 |
| F | ARG91 |
| F | MET93 |
| F | ASN103 |
| F | GLU150 |
| G | GLU131 |
| G | PRO132 |
| G | PHE133 |
| G | TYR175 |
| G | HIS177 |
| G | LEU178 |
| G | PHE188 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ZPC H 1318 |
| Chain | Residue |
| H | PHE188 |
| G | PHE19 |
| G | TYR38 |
| G | VAL40 |
| G | ARG91 |
| G | ILE101 |
| G | ASN103 |
| G | GLU150 |
| H | GLU77 |
| H | GLU131 |
| H | PHE133 |
| H | HIS177 |
| H | VAL181 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ZPC I 1318 |
| Chain | Residue |
| H | PHE19 |
| H | TYR38 |
| H | ARG91 |
| H | ILE101 |
| H | ASN103 |
| H | GLU150 |
| I | GLU77 |
| I | PHE133 |
| I | HIS177 |
| I | LEU178 |
| I | VAL181 |
| site_id | BC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ZPC J 1318 |
| Chain | Residue |
| I | PHE19 |
| I | TYR38 |
| I | ARG91 |
| I | ILE101 |
| I | ASN103 |
| I | GLU150 |
| J | GLU77 |
| J | GLU131 |
| J | PRO132 |
| J | PHE133 |
| J | TYR175 |
| J | HIS177 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 600 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU205-LEU225 | |
| A | THR234-PRO254 | |
| A | MET265-HIS285 | |
| B | LEU205-LEU225 | |
| B | THR234-PRO254 | |
| B | MET265-HIS285 | |
| C | LEU205-LEU225 | |
| C | THR234-PRO254 | |
| C | MET265-HIS285 | |
| D | LEU205-LEU225 | |
| D | THR234-PRO254 | |
| D | MET265-HIS285 | |
| E | LEU205-LEU225 | |
| E | THR234-PRO254 | |
| E | MET265-HIS285 | |
| F | LEU205-LEU225 | |
| F | THR234-PRO254 | |
| F | MET265-HIS285 | |
| G | LEU205-LEU225 | |
| G | THR234-PRO254 | |
| G | MET265-HIS285 | |
| H | LEU205-LEU225 | |
| H | THR234-PRO254 | |
| H | MET265-HIS285 | |
| I | LEU205-LEU225 | |
| I | THR234-PRO254 | |
| I | MET265-HIS285 | |
| J | LEU205-LEU225 | |
| J | THR234-PRO254 | |
| J | MET265-HIS285 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 220 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | GLU226-GLN233 | |
| A | ARG286-ARG301 | |
| B | GLU226-GLN233 | |
| B | ARG286-ARG301 | |
| C | GLU226-GLN233 | |
| C | ARG286-ARG301 | |
| D | GLU226-GLN233 | |
| D | ARG286-ARG301 | |
| E | GLU226-GLN233 | |
| E | ARG286-ARG301 | |
| F | GLU226-GLN233 | |
| F | ARG286-ARG301 | |
| G | GLU226-GLN233 | |
| G | ARG286-ARG301 | |
| H | GLU226-GLN233 | |
| H | ARG286-ARG301 | |
| I | GLU226-GLN233 | |
| I | ARG286-ARG301 | |
| J | GLU226-GLN233 | |
| J | ARG286-ARG301 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 90 |
| Details | TOPO_DOM: Periplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | ARG255-GLN264 | |
| B | ARG255-GLN264 | |
| C | ARG255-GLN264 | |
| D | ARG255-GLN264 | |
| E | ARG255-GLN264 | |
| F | ARG255-GLN264 | |
| G | ARG255-GLN264 | |
| H | ARG255-GLN264 | |
| I | ARG255-GLN264 | |
| J | ARG255-GLN264 |
