4A7X

Crystal structure of uridylate kinase from Helicobacter pylori

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006225	biological_process	UDP biosynthetic process
A	0009041	molecular_function	UMP/dUMP kinase activity
A	0016301	molecular_function	kinase activity
A	0033862	molecular_function	UMP kinase activity
A	0044210	biological_process	'de novo' CTP biosynthetic process
A	0046940	biological_process	nucleoside monophosphate phosphorylation
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006225	biological_process	UDP biosynthetic process
B	0009041	molecular_function	UMP/dUMP kinase activity
B	0016301	molecular_function	kinase activity
B	0033862	molecular_function	UMP kinase activity
B	0044210	biological_process	'de novo' CTP biosynthetic process
B	0046940	biological_process	nucleoside monophosphate phosphorylation
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006225	biological_process	UDP biosynthetic process
C	0009041	molecular_function	UMP/dUMP kinase activity
C	0016301	molecular_function	kinase activity
C	0033862	molecular_function	UMP kinase activity
C	0044210	biological_process	'de novo' CTP biosynthetic process
C	0046940	biological_process	nucleoside monophosphate phosphorylation
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006225	biological_process	UDP biosynthetic process
D	0009041	molecular_function	UMP/dUMP kinase activity
D	0016301	molecular_function	kinase activity
D	0033862	molecular_function	UMP kinase activity
D	0044210	biological_process	'de novo' CTP biosynthetic process
D	0046940	biological_process	nucleoside monophosphate phosphorylation
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006225	biological_process	UDP biosynthetic process
E	0009041	molecular_function	UMP/dUMP kinase activity
E	0016301	molecular_function	kinase activity
E	0033862	molecular_function	UMP kinase activity
E	0044210	biological_process	'de novo' CTP biosynthetic process
E	0046940	biological_process	nucleoside monophosphate phosphorylation
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006225	biological_process	UDP biosynthetic process
F	0009041	molecular_function	UMP/dUMP kinase activity
F	0016301	molecular_function	kinase activity
F	0033862	molecular_function	UMP kinase activity
F	0044210	biological_process	'de novo' CTP biosynthetic process
F	0046940	biological_process	nucleoside monophosphate phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE UDP B 1241

Chain	Residue
B	LYS13
B	GLY79
B	THR137
B	ASN139
B	PRO140
B	PHE142
B	THR144
B	HOH2024
B	HOH2050
B	GLY16
B	GLU17
B	GLY54
B	GLY55
B	GLY56
B	ARG60
B	GLY61
B	ASP76

---

site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE UDP C 1241

Chain	Residue
C	LYS13
C	SER15
C	GLY16
C	GLY55
C	GLY56
C	ARG60
C	GLY61
C	ASP76
C	GLY79
C	MET80
C	GLY136
C	THR137
C	ASN139
C	PRO140
C	PHE142
C	THR144
C	HOH2023
C	HOH2070
C	HOH2071

---

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE UDP D 1241

Chain	Residue
D	SER15
D	GLY16
D	GLU17
D	GLY54
D	GLY55
D	GLY56
D	ARG60
D	GLY61
D	ASP76
D	GLY79
D	MET80
D	GLY136
D	THR137
D	ASN139
D	PRO140
D	PHE142
D	THR144
D	HOH2004

---

site_id	AC4
Number of Residues	23
Details	BINDING SITE FOR RESIDUE UDP E 1241

Chain	Residue
E	SER15
E	GLY16
E	GLU17
E	GLY54
E	GLY55
E	GLY56
E	ILE59
E	ARG60
E	GLY61
E	ASP76
E	GLY79
E	MET80
E	THR83
E	GLY136
E	THR137
E	ASN139
E	PRO140
E	PHE141
E	PHE142
E	THR144
E	HOH2001
E	HOH2010
E	HOH2029

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	54
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01220

Chain	Residue	Details
A	GLY56
A	ARG60
A	ASP76
A	THR137
A	THR164
A	TYR170
A	ASP173
B	LYS13
B	GLY55
B	GLY56
B	ARG60
B	ASP76
B	THR137
B	THR164
B	TYR170
B	ASP173
C	LYS13
C	GLY55
C	GLY56
C	ARG60
C	ASP76
C	THR137
C	THR164
C	TYR170
C	ASP173
D	LYS13
D	GLY55
D	GLY56
D	ARG60
D	ASP76
D	THR137
D	THR164
D	TYR170
D	ASP173
E	LYS13
E	GLY55
E	GLY56
E	ARG60
E	ASP76
E	THR137
E	THR164
E	TYR170
E	ASP173
F	LYS13
F	GLY55
F	GLY56
F	ARG60
F	ASP76
F	THR137
F	THR164
F	TYR170
F	ASP173
A	LYS13
A	GLY55

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