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3ZCM

Small molecule inhibitors of the LEDGF site of HIV integrase identified by fragment screening and structure based design.

Functional Information from GO Data
ChainGOidnamespacecontents
A0003676molecular_functionnucleic acid binding
A0015074biological_processDNA integration
B0003676molecular_functionnucleic acid binding
B0015074biological_processDNA integration
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 B 1210
ChainResidue
BTHR66
BHIS67
BLYS111
BLYS136
BLYS159
BHOH2006
BHOH2007
BHOH2045

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 1210
ChainResidue
AHIS67
ALYS111
ALYS136
ALYS159
AHOH2057
ATHR66

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 B 1211
ChainResidue
BLYS71
BHIS171
BLEU172
BHOH2010
BHOH2053

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 1211
ChainResidue
ALYS71
AHIS171
ALEU172
AHOH2008
AHOH2067

site_idAC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 1212
ChainResidue
AGLU85
AALA86
AGLU87
APHE100
ALYS103
ALEU104
BARG107
BSO41212

site_idAC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 B 1212
ChainResidue
AARG107
ASO41212
BGLU85
BGLU87
BPHE100
BLYS103
BLEU104

site_idAC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE ACT B 1213
ChainResidue
AGLU87
AHOH2016
AHOH2017
AHOH2070
BTYR99
BLYS103
BACT1214

site_idAC8
Number of Residues7
DetailsBINDING SITE FOR RESIDUE ACT B 1214
ChainResidue
ATYR99
ALYS103
AHOH2034
BGLU87
BACT1213
BHOH2015
BHOH2056

site_idAC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL B 1215
ChainResidue
BGLY94
BSER123
BTHR124
BTHR125
BHOH2023
BHOH2064

site_idBC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 1213
ChainResidue
AGLY94
ASER123
ATHR124
ATHR125
AHOH2027
AHOH2080

site_idBC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE PX3 A 1214
ChainResidue
AASP167
AGLN168
AALA169
AGLU170
AHIS171
ATHR174
AHOH2083
BGLN95
BALA98
BTYR99
BTHR125
BALA128
BALA129

site_idBC3
Number of Residues12
DetailsBINDING SITE FOR RESIDUE PX3 B 1216
ChainResidue
AGLN95
AALA98
ATYR99
AALA128
AALA129
BASP167
BGLN168
BALA169
BGLU170
BHIS171
BTHR174
BMET178

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING:
ChainResidueDetails
AASP64
AASP116
BASP64
BASP116

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P04585
ChainResidueDetails
AGLU152
BGLU152

218853

PDB entries from 2024-04-24

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