3W85
Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with TT2-3-139
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0006222 | biological_process | UMP biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
A | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
B | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0006222 | biological_process | UMP biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
B | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE W85 A 401 |
Chain | Residue |
A | LYS43 |
A | SER195 |
A | GOL405 |
A | FMN410 |
A | HOH690 |
A | ARG50 |
A | ASN67 |
A | MET69 |
A | GLY70 |
A | LEU71 |
A | ASN127 |
A | PRO131 |
A | ASN194 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 402 |
Chain | Residue |
A | CYS31 |
A | SER35 |
A | PRO279 |
A | HOH532 |
B | CYS31 |
B | SER35 |
B | PRO279 |
B | HOH638 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 403 |
Chain | Residue |
A | ARG238 |
A | ARG239 |
A | HOH588 |
A | HOH665 |
A | HOH695 |
B | LYS214 |
B | PHE217 |
site_id | AC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 404 |
Chain | Residue |
A | LYS214 |
A | PHE217 |
A | HOH549 |
A | HOH721 |
B | ILE171 |
B | ARG238 |
B | ARG239 |
site_id | AC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 405 |
Chain | Residue |
A | SER129 |
A | GLN138 |
A | PRO166 |
A | PRO167 |
A | ASN194 |
A | SER195 |
A | W85401 |
A | HOH522 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 406 |
Chain | Residue |
A | PHE61 |
A | ASP203 |
A | HOH631 |
site_id | AC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL A 407 |
Chain | Residue |
A | TYR237 |
A | PRO241 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 408 |
Chain | Residue |
A | GLU205 |
A | GLU207 |
A | HOH722 |
B | TYR298 |
B | LYS309 |
site_id | AC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 409 |
Chain | Residue |
A | TYR58 |
A | MET69 |
A | GLN275 |
A | HOH540 |
A | HOH608 |
site_id | BC1 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE FMN A 410 |
Chain | Residue |
A | ALA18 |
A | ALA19 |
A | GLY20 |
A | LYS43 |
A | SER44 |
A | ASN67 |
A | ASN127 |
A | LYS164 |
A | VAL193 |
A | ASN194 |
A | GLY221 |
A | GLY222 |
A | ILE225 |
A | CYS248 |
A | GLY249 |
A | GLY250 |
A | GLY271 |
A | THR272 |
A | W85401 |
A | HOH508 |
A | HOH517 |
A | HOH528 |
A | HOH718 |
site_id | BC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NCO A 411 |
Chain | Residue |
A | GLN275 |
A | GLU276 |
A | GLY278 |
A | HOH708 |
B | GLN275 |
B | GLU276 |
B | GLY278 |
site_id | BC3 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE W85 B 401 |
Chain | Residue |
B | SER195 |
B | GOL402 |
B | FMN403 |
B | HOH681 |
B | LYS43 |
B | ASN67 |
B | MET69 |
B | GLY70 |
B | LEU71 |
B | ASN127 |
B | SER129 |
B | CYS130 |
B | PRO131 |
B | GLN138 |
B | ASN194 |
site_id | BC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL B 402 |
Chain | Residue |
B | PRO166 |
B | ASN194 |
B | SER195 |
B | GLY197 |
B | GLY219 |
B | W85401 |
B | HOH513 |
site_id | BC5 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE FMN B 403 |
Chain | Residue |
B | ALA18 |
B | ALA19 |
B | GLY20 |
B | LYS43 |
B | SER44 |
B | ASN67 |
B | ASN127 |
B | LYS164 |
B | VAL193 |
B | ASN194 |
B | GLY221 |
B | GLY222 |
B | CYS248 |
B | GLY249 |
B | GLY250 |
B | GLY271 |
B | THR272 |
B | W85401 |
B | HOH505 |
B | HOH515 |
B | HOH520 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Nucleophile => ECO:0000250 |
Chain | Residue | Details |
A | CYS130 | |
B | CYS130 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18302934 |
Chain | Residue | Details |
A | VAL193 | |
A | GLY222 | |
A | GLY249 | |
A | GLY271 | |
B | ALA19 | |
B | LYS164 | |
B | VAL193 | |
B | GLY222 | |
B | GLY249 | |
B | GLY271 | |
A | ALA19 | |
A | LYS164 |
site_id | SWS_FT_FI3 |
Number of Residues | 10 |
Details | BINDING: |
Chain | Residue | Details |
A | ASN194 | |
B | LYS43 | |
B | ASN67 | |
B | ASN127 | |
B | ASN132 | |
B | ASN194 | |
A | LYS43 | |
A | ASN67 | |
A | ASN127 | |
A | ASN132 |