3TCY
Crystallographic structure of phenylalanine hydroxylase from Chromobacterium violaceum (cPAH) bound to phenylalanine in a site distal to the active site
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0004505 | molecular_function | phenylalanine 4-monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0006559 | biological_process | L-phenylalanine catabolic process |
| A | 0006571 | biological_process | tyrosine biosynthetic process |
| A | 0009072 | biological_process | aromatic amino acid metabolic process |
| A | 0016714 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen |
| A | 0019293 | biological_process | tyrosine biosynthetic process, by oxidation of phenylalanine |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PHE A 302 |
| Chain | Residue |
| A | ALA158 |
| A | HOH481 |
| A | TYR159 |
| A | LYS165 |
| A | THR254 |
| A | ALA255 |
| A | PRO256 |
| A | ASP257 |
| A | PHE258 |
| A | HOH317 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO A 298 |
| Chain | Residue |
| A | HIS138 |
| A | HIS143 |
| A | GLU184 |
| A | HOH457 |
| A | HOH484 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CO A 299 |
| Chain | Residue |
| A | HIS22 |
| A | GLU68 |
| A | HOH411 |
| A | HOH463 |
| A | HOH508 |
| A | HOH516 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 300 |
| Chain | Residue |
| A | ASP154 |
| A | SER216 |
| A | ASN218 |
| A | HOH474 |
| A | HOH487 |
| A | HOH494 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 301 |
| Chain | Residue |
| A | HIS126 |
| A | ASP245 |
| A | ASP267 |
Functional Information from PROSITE/UniProt
| site_id | PS00367 |
| Number of Residues | 12 |
| Details | BH4_AAA_HYDROXYL_1 Biopterin-dependent aromatic amino acid hydroxylases signature. PDvfHDLFGHVP |
| Chain | Residue | Details |
| A | PRO134-PRO145 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | HIS138 | |
| A | HIS143 | |
| A | GLU184 |
