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3T1E

The structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a 4-helix bundle stalk

Functional Information from GO Data
ChainGOidnamespacecontents
A0004308molecular_functionexo-alpha-sialidase activity
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0019031cellular_componentviral envelope
A0019058biological_processviral life cycle
A0019062biological_processvirion attachment to host cell
A0020002cellular_componenthost cell plasma membrane
A0042802molecular_functionidentical protein binding
A0046718biological_processsymbiont entry into host cell
A0046789molecular_functionhost cell surface receptor binding
A0052794molecular_functionexo-alpha-(2->3)-sialidase activity
A0052795molecular_functionexo-alpha-(2->6)-sialidase activity
A0052796molecular_functionexo-alpha-(2->8)-sialidase activity
A0055036cellular_componentvirion membrane
B0004308molecular_functionexo-alpha-sialidase activity
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0019031cellular_componentviral envelope
B0019058biological_processviral life cycle
B0019062biological_processvirion attachment to host cell
B0020002cellular_componenthost cell plasma membrane
B0042802molecular_functionidentical protein binding
B0046718biological_processsymbiont entry into host cell
B0046789molecular_functionhost cell surface receptor binding
B0052794molecular_functionexo-alpha-(2->3)-sialidase activity
B0052795molecular_functionexo-alpha-(2->6)-sialidase activity
B0052796molecular_functionexo-alpha-(2->8)-sialidase activity
B0055036cellular_componentvirion membrane
E0004308molecular_functionexo-alpha-sialidase activity
E0016020cellular_componentmembrane
E0016787molecular_functionhydrolase activity
E0019031cellular_componentviral envelope
E0019058biological_processviral life cycle
E0019062biological_processvirion attachment to host cell
E0020002cellular_componenthost cell plasma membrane
E0042802molecular_functionidentical protein binding
E0046718biological_processsymbiont entry into host cell
E0046789molecular_functionhost cell surface receptor binding
E0052794molecular_functionexo-alpha-(2->3)-sialidase activity
E0052795molecular_functionexo-alpha-(2->6)-sialidase activity
E0052796molecular_functionexo-alpha-(2->8)-sialidase activity
E0055036cellular_componentvirion membrane
F0004308molecular_functionexo-alpha-sialidase activity
F0016020cellular_componentmembrane
F0016787molecular_functionhydrolase activity
F0019031cellular_componentviral envelope
F0019058biological_processviral life cycle
F0019062biological_processvirion attachment to host cell
F0020002cellular_componenthost cell plasma membrane
F0042802molecular_functionidentical protein binding
F0046718biological_processsymbiont entry into host cell
F0046789molecular_functionhost cell surface receptor binding
F0052794molecular_functionexo-alpha-(2->3)-sialidase activity
F0052795molecular_functionexo-alpha-(2->6)-sialidase activity
F0052796molecular_functionexo-alpha-(2->8)-sialidase activity
F0055036cellular_componentvirion membrane
Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. MSATHC
ChainResidueDetails
AMET180-CYS185

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2084
DetailsTOPO_DOM: Virion surface => ECO:0000255
ChainResidueDetails
AGLU49-VAL570
BGLU49-VAL570
EGLU49-VAL570
FGLU49-VAL570

site_idSWS_FT_FI2
Number of Residues12
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255
ChainResidueDetails
AASN119
FASN119
FASN507
FASN537
AASN507
AASN537
BASN119
BASN507
BASN537
EASN119
EASN507
EASN537

site_idSWS_FT_FI3
Number of Residues12
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000250|UniProtKB:Q91UL0
ChainResidueDetails
AASN340
FASN340
FASN432
FASN480
AASN432
AASN480
BASN340
BASN432
BASN480
EASN340
EASN432
EASN480

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PDB entries from 2024-05-01

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