3QW4
Structure of Leishmania donovani UMP synthase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| B | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| C | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| C | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0016831 | molecular_function | carboxy-lyase activity |
| C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE U5P B 7485 |
| Chain | Residue |
| B | ASP21 |
| B | SER228 |
| B | ARG229 |
| C | ASP87 |
| C | THR91 |
| B | LYS49 |
| B | ASN51 |
| B | ASP82 |
| B | LYS84 |
| B | THR136 |
| B | SER137 |
| B | PRO199 |
| B | GLN204 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL C 453 |
| Chain | Residue |
| B | ARG345 |
| C | ARG291 |
| C | TYR324 |
| C | ARG346 |
| C | HOH472 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE U5P C 7485 |
| Chain | Residue |
| C | LYS279 |
| C | TYR287 |
| C | ILE288 |
| C | ARG291 |
| C | ASP371 |
| C | ASP372 |
| C | LEU373 |
| C | VAL374 |
| C | SER375 |
| C | THR376 |
| C | GLY377 |
| C | GLU378 |
| C | THR379 |
| C | ARG403 |
| C | HOH465 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE U5P C 454 |
| Chain | Residue |
| B | ASP87 |
| B | ILE88 |
| B | THR91 |
| C | ASP21 |
| C | LYS49 |
| C | ASN51 |
| C | ASP82 |
| C | THR136 |
| C | SER137 |
| C | PRO199 |
| C | SER228 |
| C | ARG229 |
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VVIIDDLVSTGeT |
| Chain | Residue | Details |
| B | VAL367-THR379 |
| site_id | PS00156 |
| Number of Residues | 14 |
| Details | OMPDECASE Orotidine 5'-phosphate decarboxylase active site. VVlDaKrgDIAdTA |
| Chain | Residue | Details |
| B | VAL79-ALA92 |
