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3QKD

Crystal structure of Bcl-xL in complex with a Quinazoline sulfonamide inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0042981biological_processregulation of apoptotic process
B0042981biological_processregulation of apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE HI0 A 218
ChainResidue
AALA93
AGLY138
AARG139
AVAL141
AALA142
APHE191
ATYR195
AHOH236
AHOH242
BARG102
BGLU158
AGLU96
AARG100
ATYR101
APHE105
AVAL126
AGLU129
ALEU130
AASN136

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL A 219
ChainResidue
AGLY134
AHOH246

site_idAC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE GOL A 247
ChainResidue
ASER110
AGLN111
ALEU112
AHIS113
AHOH222
BGLN19
BLYS20
BGLU98
BHOH239
BHOH292

site_idAC4
Number of Residues16
DetailsBINDING SITE FOR RESIDUE HI0 B 218
ChainResidue
BALA93
BGLU96
BPHE97
BARG100
BTYR101
BPHE105
BLEU108
BGLU129
BTRP137
BGLY138
BARG139
BVAL141
BALA142
BPHE191
BTYR195
BHOH264

Functional Information from PROSITE/UniProt
site_idPS01080
Number of Residues19
DetailsBH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFsFGG
ChainResidueDetails
ALEU130-GLY148

site_idPS01258
Number of Residues12
DetailsBH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqenGGWDtFV
ChainResidueDetails
ATRP181-VAL192

site_idPS01259
Number of Residues15
DetailsBH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VkqaLReAGDEFELR
ChainResidueDetails
AVAL86-ARG100

site_idPS01260
Number of Residues21
DetailsBH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. SNRELVvDFLSYKLSQKGYsW
ChainResidueDetails
ASER4-TRP24

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Cleavage; by caspase-1
ChainResidueDetails
ATYR101
BTYR101

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PLK3 => ECO:0000269|PubMed:21840391
ChainResidueDetails
AALA89
BALA89

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:19917720
ChainResidueDetails
AARG102
BARG102

219140

PDB entries from 2024-05-01

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