Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3Q4J

Structure of a small peptide ligand bound to E.coli DNA sliding clamp

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006271	biological_process	DNA strand elongation involved in DNA replication
A	0006974	biological_process	DNA damage response
A	0008408	molecular_function	3'-5' exonuclease activity
A	0009360	cellular_component	DNA polymerase III complex
A	0030174	biological_process	regulation of DNA-templated DNA replication initiation
A	0030894	cellular_component	replisome
A	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
A	0042276	biological_process	error-prone translesion synthesis
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0044787	biological_process	bacterial-type DNA replication
A	1990078	cellular_component	replication inhibiting complex
A	1990085	cellular_component	Hda-beta clamp complex
B	0003677	molecular_function	DNA binding
B	0003887	molecular_function	DNA-directed DNA polymerase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
B	0006271	biological_process	DNA strand elongation involved in DNA replication
B	0006974	biological_process	DNA damage response
B	0008408	molecular_function	3'-5' exonuclease activity
B	0009360	cellular_component	DNA polymerase III complex
B	0030174	biological_process	regulation of DNA-templated DNA replication initiation
B	0030894	cellular_component	replisome
B	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
B	0042276	biological_process	error-prone translesion synthesis
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0044787	biological_process	bacterial-type DNA replication
B	1990078	cellular_component	replication inhibiting complex
B	1990085	cellular_component	Hda-beta clamp complex
C	0003677	molecular_function	DNA binding
C	0003887	molecular_function	DNA-directed DNA polymerase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006260	biological_process	DNA replication
C	0006261	biological_process	DNA-templated DNA replication
C	0006271	biological_process	DNA strand elongation involved in DNA replication
C	0006974	biological_process	DNA damage response
C	0008408	molecular_function	3'-5' exonuclease activity
C	0009360	cellular_component	DNA polymerase III complex
C	0030174	biological_process	regulation of DNA-templated DNA replication initiation
C	0030894	cellular_component	replisome
C	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
C	0042276	biological_process	error-prone translesion synthesis
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0044787	biological_process	bacterial-type DNA replication
C	1990078	cellular_component	replication inhibiting complex
C	1990085	cellular_component	Hda-beta clamp complex
D	0003677	molecular_function	DNA binding
D	0003887	molecular_function	DNA-directed DNA polymerase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006260	biological_process	DNA replication
D	0006261	biological_process	DNA-templated DNA replication
D	0006271	biological_process	DNA strand elongation involved in DNA replication
D	0006974	biological_process	DNA damage response
D	0008408	molecular_function	3'-5' exonuclease activity
D	0009360	cellular_component	DNA polymerase III complex
D	0030174	biological_process	regulation of DNA-templated DNA replication initiation
D	0030894	cellular_component	replisome
D	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
D	0042276	biological_process	error-prone translesion synthesis
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0044787	biological_process	bacterial-type DNA replication
D	1990078	cellular_component	replication inhibiting complex
D	1990085	cellular_component	Hda-beta clamp complex
E	0003677	molecular_function	DNA binding
E	0003887	molecular_function	DNA-directed DNA polymerase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006260	biological_process	DNA replication
E	0006261	biological_process	DNA-templated DNA replication
E	0006271	biological_process	DNA strand elongation involved in DNA replication
E	0006974	biological_process	DNA damage response
E	0008408	molecular_function	3'-5' exonuclease activity
E	0009360	cellular_component	DNA polymerase III complex
E	0030174	biological_process	regulation of DNA-templated DNA replication initiation
E	0030894	cellular_component	replisome
E	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
E	0042276	biological_process	error-prone translesion synthesis
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0044787	biological_process	bacterial-type DNA replication
E	1990078	cellular_component	replication inhibiting complex
E	1990085	cellular_component	Hda-beta clamp complex
F	0003677	molecular_function	DNA binding
F	0003887	molecular_function	DNA-directed DNA polymerase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006260	biological_process	DNA replication
F	0006261	biological_process	DNA-templated DNA replication
F	0006271	biological_process	DNA strand elongation involved in DNA replication
F	0006974	biological_process	DNA damage response
F	0008408	molecular_function	3'-5' exonuclease activity
F	0009360	cellular_component	DNA polymerase III complex
F	0030174	biological_process	regulation of DNA-templated DNA replication initiation
F	0030894	cellular_component	replisome
F	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
F	0042276	biological_process	error-prone translesion synthesis
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0044787	biological_process	bacterial-type DNA replication
F	1990078	cellular_component	replication inhibiting complex
F	1990085	cellular_component	Hda-beta clamp complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR CHAIN H OF PEPTIDE LIGAND

Chain	Residue
B	ARG152
B	TYR323
B	ALA353
B	VAL360
B	MET362
B	PRO363
B	MET364
B	ARG365
B	THR172
B	GLY174
B	HIS175
B	ARG176
B	LEU177
B	PRO242
B	VAL247
B	ASN320

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR CHAIN I OF PEPTIDE LIGAND

Chain	Residue
C	THR172
C	GLY174
C	HIS175
C	ARG176
C	LEU177
C	PRO242
C	ASN335
C	VAL344
C	VAL360
C	MET362
C	PRO363
C	MET364
C	ARG365
E	ASN251

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR CHAIN J OF PEPTIDE LIGAND

Chain	Residue
D	GLY174
D	HIS175
D	ARG176
D	PRO242
D	VAL247
D	ASN335
D	MET362
D	PRO363
D	MET364
D	ARG365

site_id	AC4
Number of Residues	18
Details	BINDING SITE FOR CHAIN K OF PEPTIDE LIGAND

Chain	Residue
E	ARG152
E	THR172
E	GLY174
E	HIS175
E	ARG176
E	VAL247
E	ASN320
E	TYR323
E	GLU334
E	ASN335
E	VAL344
E	ALA353
E	VAL360
E	MET362
E	PRO363
E	MET364
E	ARG365
E	HOH442

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR CHAIN L OF PEPTIDE LIGAND

Chain	Residue
F	ARG152
F	THR172
F	GLY174
F	HIS175
F	ARG176
F	PRO242
F	VAL247
F	TYR323
F	MET362
F	PRO363
F	MET364
F	ARG365

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000305\|PubMed:18191219

Chain	Residue	Details
A	ARG24
D	ARG24
D	GLN149
D	TYR153
E	ARG24
E	GLN149
E	TYR153
F	ARG24
F	GLN149
F	TYR153
A	GLN149
A	TYR153
B	ARG24
B	GLN149
B	TYR153
C	ARG24
C	GLN149
C	TYR153

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:18191219

Chain	Residue	Details
A	ARG73
B	ARG73
C	ARG73
D	ARG73
E	ARG73
F	ARG73

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)