3PMW

Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GLU A 301

Chain	Residue
A	TYR62
A	TYR221
A	HOH433
A	HOH491
A	PRO90
A	LEU91
A	THR92
A	ARG97
A	GLY142
A	SER143
A	THR144
A	GLU194

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 302

Chain	Residue
A	ASP140
A	SER141
A	LYS145
A	ARG149
A	HOH401
A	HOH498

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 303

Chain	Residue
A	GLU28
A	GLY29
A	ASN30
A	ARG150
A	HOH534

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 304

Chain	Residue
A	MET20
A	HIS24
A	GLU25
A	ARG32
A	LYS241
A	SO4306

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 305

Chain	Residue
A	ARG204
A	HOH414
A	HOH473

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 306

Chain	Residue
A	GLU25
A	ARG32
A	HIS47
A	LYS241
A	GLN245
A	SO4304
A	GOL310

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 307

Chain	Residue
A	ARG204
A	LYS259

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 308

Chain	Residue
A	SER195
A	GLU199
A	ASN215
A	HOH520

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 309

Chain	Residue
A	LYS51
A	ARG149
A	TRP160
A	ARG164

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 310

Chain	Residue
A	ARG32
A	LEU54
A	SO4306

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 311

Chain	Residue
A	MET108
A	SER109
A	SER218
A	G69312
A	G69312

---

site_id	BC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE G69 A 312

Chain	Residue
A	ILE93
A	ILE93
A	LYS105
A	LYS105
A	PRO106
A	PRO106
A	SER109
A	LYS219
A	LYS219
A	GLY220
A	GLY220
A	VAL239
A	LEU240
A	LEU240
A	SER243
A	SER243
A	DMS311
A	DMS311

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	THR92
A	ARG97
A	SER143
A	THR144
A	GLU194
A	PRO90

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG149
A	LYS241
A	ARG65

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE122

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER151

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER185

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN4

---