3PB6

Crystal structure of the catalytic domain of human Golgi-resident glutaminyl cyclase at pH 6.5

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CAC X 390

Chain	Residue
X	HIS168
X	HOH641
X	ASP186
X	GLU225
X	GLU226
X	ASP269
X	TRP350
X	HIS351
X	ZN400
X	HOH492

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN X 400

Chain	Residue
X	ASP186
X	GLU226
X	TRP350
X	HIS351
X	CAC390

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:Q16769

Chain	Residue	Details
X	GLU225
X	ASP269

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q16769

Chain	Residue	Details
X	ASP186
X	GLU226
X	HIS351

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