Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3O8J

Crystal structure of 2-methylcitrate synthase (PrpC) from Salmonella typhimurium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004108	molecular_function	citrate (Si)-synthase activity
A	0005737	cellular_component	cytoplasm
A	0005975	biological_process	carbohydrate metabolic process
A	0006099	biological_process	tricarboxylic acid cycle
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0019679	biological_process	propionate metabolic process, methylcitrate cycle
A	0036440	molecular_function	citrate synthase activity
A	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
A	0050440	molecular_function	2-methylcitrate synthase activity
B	0004108	molecular_function	citrate (Si)-synthase activity
B	0005737	cellular_component	cytoplasm
B	0005975	biological_process	carbohydrate metabolic process
B	0006099	biological_process	tricarboxylic acid cycle
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0019679	biological_process	propionate metabolic process, methylcitrate cycle
B	0036440	molecular_function	citrate synthase activity
B	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
B	0050440	molecular_function	2-methylcitrate synthase activity
C	0004108	molecular_function	citrate (Si)-synthase activity
C	0005737	cellular_component	cytoplasm
C	0005975	biological_process	carbohydrate metabolic process
C	0006099	biological_process	tricarboxylic acid cycle
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0019679	biological_process	propionate metabolic process, methylcitrate cycle
C	0036440	molecular_function	citrate synthase activity
C	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
C	0050440	molecular_function	2-methylcitrate synthase activity
D	0004108	molecular_function	citrate (Si)-synthase activity
D	0005737	cellular_component	cytoplasm
D	0005975	biological_process	carbohydrate metabolic process
D	0006099	biological_process	tricarboxylic acid cycle
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0019679	biological_process	propionate metabolic process, methylcitrate cycle
D	0036440	molecular_function	citrate synthase activity
D	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
D	0050440	molecular_function	2-methylcitrate synthase activity
E	0004108	molecular_function	citrate (Si)-synthase activity
E	0005737	cellular_component	cytoplasm
E	0005975	biological_process	carbohydrate metabolic process
E	0006099	biological_process	tricarboxylic acid cycle
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0019679	biological_process	propionate metabolic process, methylcitrate cycle
E	0036440	molecular_function	citrate synthase activity
E	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
E	0050440	molecular_function	2-methylcitrate synthase activity
F	0004108	molecular_function	citrate (Si)-synthase activity
F	0005737	cellular_component	cytoplasm
F	0005975	biological_process	carbohydrate metabolic process
F	0006099	biological_process	tricarboxylic acid cycle
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0019679	biological_process	propionate metabolic process, methylcitrate cycle
F	0036440	molecular_function	citrate synthase activity
F	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
F	0050440	molecular_function	2-methylcitrate synthase activity
G	0004108	molecular_function	citrate (Si)-synthase activity
G	0005737	cellular_component	cytoplasm
G	0005975	biological_process	carbohydrate metabolic process
G	0006099	biological_process	tricarboxylic acid cycle
G	0016740	molecular_function	transferase activity
G	0016746	molecular_function	acyltransferase activity
G	0019679	biological_process	propionate metabolic process, methylcitrate cycle
G	0036440	molecular_function	citrate synthase activity
G	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
G	0050440	molecular_function	2-methylcitrate synthase activity
H	0004108	molecular_function	citrate (Si)-synthase activity
H	0005737	cellular_component	cytoplasm
H	0005975	biological_process	carbohydrate metabolic process
H	0006099	biological_process	tricarboxylic acid cycle
H	0016740	molecular_function	transferase activity
H	0016746	molecular_function	acyltransferase activity
H	0019679	biological_process	propionate metabolic process, methylcitrate cycle
H	0036440	molecular_function	citrate synthase activity
H	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
H	0050440	molecular_function	2-methylcitrate synthase activity
I	0004108	molecular_function	citrate (Si)-synthase activity
I	0005737	cellular_component	cytoplasm
I	0005975	biological_process	carbohydrate metabolic process
I	0006099	biological_process	tricarboxylic acid cycle
I	0016740	molecular_function	transferase activity
I	0016746	molecular_function	acyltransferase activity
I	0019679	biological_process	propionate metabolic process, methylcitrate cycle
I	0036440	molecular_function	citrate synthase activity
I	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
I	0050440	molecular_function	2-methylcitrate synthase activity
J	0004108	molecular_function	citrate (Si)-synthase activity
J	0005737	cellular_component	cytoplasm
J	0005975	biological_process	carbohydrate metabolic process
J	0006099	biological_process	tricarboxylic acid cycle
J	0016740	molecular_function	transferase activity
J	0016746	molecular_function	acyltransferase activity
J	0019679	biological_process	propionate metabolic process, methylcitrate cycle
J	0036440	molecular_function	citrate synthase activity
J	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
J	0050440	molecular_function	2-methylcitrate synthase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 409

Chain	Residue
A	SER185
A	VAL290
A	GLN293
A	HOH1101
A	HOH1172

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 410

Chain	Residue
B	PHE346
B	ARG350
B	HOH1171
B	HIS200
B	ASN203
B	HIS235
B	HIS274

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C 401

Chain	Residue
C	HIS200
C	ASN203
C	HIS274
C	ARG283
C	PHE346
C	ARG350
C	HOH569

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL E 402

Chain	Residue
E	HIS200
E	ASN203
E	HIS235
E	HIS274
E	ARG350

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL E 408

Chain	Residue
A	GLU316
E	ASP258
E	LYS261
E	ARG262
E	ASN265
E	GLU267

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL F 407

Chain	Residue
F	VAL290
F	GLN293

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL F 411

Chain	Residue
F	ASN203
F	HIS235
F	HIS274
F	PHE346
F	ARG350

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL G 403

Chain	Residue
G	HIS200
G	ASN203
G	HIS235
G	HIS274
G	ARG350

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL H 404

Chain	Residue
H	HIS200
H	ASN203
H	HIS235
H	ARG350
H	HOH519
H	HOH520
H	HOH1150

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL I 405

Chain	Residue
I	HIS200
I	ASN203
I	HIS274
I	VAL276
I	ARG350
I	HOH419
I	HOH940

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL J 406

Chain	Residue
J	HIS200
J	ASN203
J	HIS235
J	HIS274
J	ARG350

Functional Information from PROSITE/UniProt

site_id	PS00480
Number of Residues	13
Details	CITRATE_SYNTHASE Citrate synthase signature. GFGHpVy.TiaDPR

Chain	Residue	Details
A	GLY271-ARG283

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	ACT_SITE: ACT_SITE => ECO:0000250\|UniProtKB:O34002, ECO:0000305\|PubMed:20970504

Chain	Residue	Details
A	HIS235
A	HIS274
A	ASP325
B	HIS235
B	HIS274
B	ASP325
C	HIS235
C	HIS274
C	ASP325
D	HIS235
D	HIS274
D	ASP325
E	HIS235
E	HIS274
E	ASP325
F	HIS235
F	HIS274
F	ASP325
G	HIS235
G	HIS274
G	ASP325
H	HIS235
H	HIS274
H	ASP325
I	HIS235
I	HIS274
I	ASP325
J	HIS235
J	HIS274
J	ASP325

site_id	SWS_FT_FI2
Number of Residues	50
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:I6Y9Q3

Chain	Residue	Details
A	LYS82
A	HIS200
A	ARG283
A	ARG350
A	ARG369
B	LYS82
B	HIS200
B	ARG283
B	ARG350
B	ARG369
C	LYS82
C	HIS200
C	ARG283
C	ARG350
C	ARG369
D	LYS82
D	HIS200
D	ARG283
D	ARG350
D	ARG369
E	LYS82
E	HIS200
E	ARG283
E	ARG350
E	ARG369
F	LYS82
F	HIS200
F	ARG283
F	ARG350
F	ARG369
G	LYS82
G	HIS200
G	ARG283
G	ARG350
G	ARG369
H	LYS82
H	HIS200
H	ARG283
H	ARG350
H	ARG369
I	LYS82
I	HIS200
I	ARG283
I	ARG350
I	ARG369
J	LYS82
J	HIS200
J	ARG283
J	ARG350
J	ARG369

site_id	SWS_FT_FI3
Number of Residues	10
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:O34002

Chain	Residue	Details
A	VAL268
B	VAL268
C	VAL268
D	VAL268
E	VAL268
F	VAL268
G	VAL268
H	VAL268
I	VAL268
J	VAL268

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)