3O08
Crystal structure of dimeric KlHxk1 in crystal form I
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001678 | biological_process | intracellular glucose homeostasis |
| A | 0004340 | molecular_function | glucokinase activity |
| A | 0004396 | molecular_function | hexokinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005536 | molecular_function | glucose binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0006013 | biological_process | mannose metabolic process |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0006096 | biological_process | glycolytic process |
| A | 0008865 | molecular_function | fructokinase activity |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| A | 0019158 | molecular_function | mannokinase activity |
| A | 0019318 | biological_process | hexose metabolic process |
| A | 0019637 | biological_process | organophosphate metabolic process |
| A | 0046835 | biological_process | carbohydrate phosphorylation |
| A | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| A | 1901135 | biological_process | carbohydrate derivative metabolic process |
| B | 0001678 | biological_process | intracellular glucose homeostasis |
| B | 0004340 | molecular_function | glucokinase activity |
| B | 0004396 | molecular_function | hexokinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005536 | molecular_function | glucose binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006006 | biological_process | glucose metabolic process |
| B | 0006013 | biological_process | mannose metabolic process |
| B | 0006091 | biological_process | generation of precursor metabolites and energy |
| B | 0006096 | biological_process | glycolytic process |
| B | 0008865 | molecular_function | fructokinase activity |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| B | 0019158 | molecular_function | mannokinase activity |
| B | 0019318 | biological_process | hexose metabolic process |
| B | 0019637 | biological_process | organophosphate metabolic process |
| B | 0046835 | biological_process | carbohydrate phosphorylation |
| B | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| B | 1901135 | biological_process | carbohydrate derivative metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 486 |
| Chain | Residue |
| A | GLY232 |
| A | THR233 |
| A | GLY234 |
| A | GLY417 |
| A | SER418 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 487 |
| Chain | Residue |
| A | PRO280 |
| A | HOH555 |
| A | LYS40 |
| A | SER128 |
| A | LYS132 |
| A | VAL278 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 488 |
| Chain | Residue |
| A | PRO223 |
| A | GLN224 |
| A | LYS226 |
| A | GLY407 |
| A | TYR408 |
| A | LYS409 |
| A | THR410 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 489 |
| Chain | Residue |
| A | PHE420 |
| A | LYS427 |
| A | VAL453 |
| A | ALA454 |
| A | HOH640 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 490 |
| Chain | Residue |
| A | GLY417 |
| A | SER418 |
| A | ASN421 |
| A | ARG422 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 491 |
| Chain | Residue |
| A | GLN432 |
| A | LYS435 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 492 |
| Chain | Residue |
| A | GLY88 |
| A | GLY89 |
| A | THR90 |
| A | ASN91 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 493 |
| Chain | Residue |
| A | SER292 |
| A | PRO293 |
| A | ARG294 |
| A | GLN297 |
| A | LYS302 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 494 |
| Chain | Residue |
| A | LYS444 |
| A | MET445 |
| A | HOH646 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NHE B 486 |
| Chain | Residue |
| B | TYR73 |
| B | LYS226 |
| B | TYR408 |
| B | SO4491 |
| B | HOH571 |
| B | HOH614 |
| B | HOH638 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 487 |
| Chain | Residue |
| B | GLY232 |
| B | THR233 |
| B | GLY417 |
| B | SER418 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 488 |
| Chain | Residue |
| B | SER37 |
| B | SER38 |
| B | ARG393 |
| B | HOH604 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 489 |
| Chain | Residue |
| B | VAL242 |
| B | ARG406 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 490 |
| Chain | Residue |
| B | GLY417 |
| B | SER418 |
| B | ASN421 |
| B | ARG422 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 491 |
| Chain | Residue |
| B | LYS226 |
| B | GLY407 |
| B | TYR408 |
| B | LYS409 |
| B | THR410 |
| B | NHE486 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 492 |
| Chain | Residue |
| B | LYS444 |
| B | MET445 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 493 |
| Chain | Residue |
| B | PHE420 |
| B | LYS427 |
| B | VAL453 |
| B | ALA454 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 494 |
| Chain | Residue |
| B | SER292 |
| B | ARG294 |
| B | GLN298 |
| B | LYS302 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 495 |
| Chain | Residue |
| A | TYR112 |
| B | ASN356 |
| B | VAL374 |
| B | ARG377 |
| site_id | CC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 496 |
| Chain | Residue |
| B | GLN432 |
| B | LYS435 |
| site_id | CC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 497 |
| Chain | Residue |
| B | VAL340 |
| B | TYR345 |
| B | ASN367 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 498 |
| Chain | Residue |
| A | PHE354 |
| B | ASN91 |
| B | HOH590 |
| B | HOH648 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 499 |
| Chain | Residue |
| B | PRO424 |
| B | GLY425 |
| B | GLU428 |
| B | HOH548 |
Functional Information from PROSITE/UniProt
| site_id | PS00378 |
| Number of Residues | 26 |
| Details | HEXOKINASE_1 Hexokinase domain signature. LGFTFSYPasqkkINsgvLqrWTKgF |
| Chain | Residue | Details |
| A | LEU152-PHE177 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS111 | |
| B | LYS111 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:12882981 |
| Chain | Residue | Details |
| A | SER15 | |
| B | SER15 |
