3N7S
Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004948 | molecular_function | calcitonin receptor activity |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0016020 | cellular_component | membrane |
| B | 0004930 | molecular_function | G protein-coupled receptor activity |
| B | 0004948 | molecular_function | calcitonin receptor activity |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0016020 | cellular_component | membrane |
| C | 0006886 | biological_process | intracellular protein transport |
| C | 0008277 | biological_process | regulation of G protein-coupled receptor signaling pathway |
| C | 0015026 | molecular_function | coreceptor activity |
| C | 0016020 | cellular_component | membrane |
| D | 0006886 | biological_process | intracellular protein transport |
| D | 0008277 | biological_process | regulation of G protein-coupled receptor signaling pathway |
| D | 0015026 | molecular_function | coreceptor activity |
| D | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 3N6 A 1 |
| Chain | Residue |
| A | ASP70 |
| A | HOH201 |
| A | HOH202 |
| A | HOH204 |
| C | ASN31 |
| C | LEU39 |
| C | LYS79 |
| C | LEU80 |
| D | ALA70 |
| D | ASP71 |
| D | TRP74 |
| A | GLY71 |
| D | TRP84 |
| A | TRP72 |
| A | PHE92 |
| A | ASP94 |
| A | ARG119 |
| A | TRP121 |
| A | THR122 |
| A | TYR124 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 3N7 B 1 |
| Chain | Residue |
| B | LYS40 |
| B | ALA44 |
| B | GLU47 |
| B | CYS48 |
| B | LYS51 |
| B | CYS74 |
| B | TRP75 |
| B | ASN76 |
| B | SER84 |
| B | MET85 |
| B | GLN86 |
| B | ASP90 |
| B | HOH208 |
| B | HOH216 |
| B | HOH219 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1 |
| Chain | Residue |
| B | MET42 |
| C | ALA70 |
| C | ASP71 |
| C | TRP74 |
| C | TRP84 |
| C | VAL111 |
Functional Information from PROSITE/UniProt
| site_id | PS00649 |
| Number of Residues | 25 |
| Details | G_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtWDgwl.CWndVaagtesmqlCP |
| Chain | Residue | Details |
| A | CYS65-PRO89 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 180 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| C | CYS27-SER117 | |
| D | CYS27-SER117 | |
| A | ASN123 | |
| B | ASN66 | |
| B | ASN118 | |
| B | ASN123 |
