3N2M
Crystal structure of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-6-amino-UMP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
A | 0005515 | molecular_function | protein binding |
A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0016831 | molecular_function | carboxy-lyase activity |
A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
B | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
B | 0005515 | molecular_function | protein binding |
B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0016831 | molecular_function | carboxy-lyase activity |
B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE FNU A 324 |
Chain | Residue |
A | ASP23 |
A | PRO264 |
A | GLN269 |
A | ASN291 |
A | GLY293 |
A | ARG294 |
A | HOH329 |
A | HOH340 |
A | HOH359 |
A | HOH369 |
A | HOH385 |
A | LYS102 |
B | ASP141 |
B | ILE142 |
B | THR145 |
A | ASN104 |
A | ASP136 |
A | LYS138 |
A | LEU191 |
A | THR194 |
A | THR195 |
A | VAL240 |
site_id | AC2 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE TRS A 325 |
Chain | Residue |
A | MET1 |
A | PHE3 |
A | ASN40 |
A | ASP160 |
A | TYR185 |
A | TYR186 |
A | GLU235 |
A | HOH351 |
A | HOH425 |
A | HOH426 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PEG A 326 |
Chain | Residue |
A | ASN299 |
A | PRO300 |
A | MET308 |
A | GLN312 |
site_id | AC4 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE FNU B 324 |
Chain | Residue |
A | ASP141 |
A | ILE142 |
A | THR145 |
B | ASP23 |
B | LYS102 |
B | ASN104 |
B | ASP136 |
B | LYS138 |
B | LEU191 |
B | THR194 |
B | THR195 |
B | VAL240 |
B | PRO264 |
B | GLN269 |
B | ASN291 |
B | GLY293 |
B | ARG294 |
B | HOH333 |
B | HOH339 |
B | HOH350 |
B | HOH351 |
B | HOH361 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 B 325 |
Chain | Residue |
B | LYS147 |
B | ARG150 |
B | ASP179 |
B | GLU180 |
B | GLU181 |
B | HOH433 |
site_id | AC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO B 326 |
Chain | Residue |
A | ASN196 |
A | PRO197 |
A | HOH519 |
B | ILE142 |
B | GLY143 |
B | ASN171 |
B | HOH396 |
B | HOH429 |
Functional Information from PROSITE/UniProt
site_id | PS00156 |
Number of Residues | 14 |
Details | OMPDECASE Orotidine 5'-phosphate decarboxylase active site. TIlDmKinDIGnTV |
Chain | Residue | Details |
A | THR133-VAL146 |