3MWA
Crystal structure of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase covalently modified by 2-prime-fluoro-6-iodo-UMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE UFT A 1000 |
| Chain | Residue |
| A | ASP23 |
| A | ASN291 |
| A | GLY293 |
| A | ARG294 |
| A | HOH337 |
| A | HOH347 |
| A | HOH361 |
| A | HOH374 |
| A | HOH399 |
| B | ASP141 |
| B | ILE142 |
| A | LYS102 |
| B | THR145 |
| A | ASN104 |
| A | ASP136 |
| A | LYS138 |
| A | THR194 |
| A | THR195 |
| A | PRO264 |
| A | GLN269 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE UFT B 1000 |
| Chain | Residue |
| A | ASP141 |
| A | ILE142 |
| A | THR145 |
| B | ASP23 |
| B | LYS102 |
| B | ASN104 |
| B | ASP136 |
| B | LYS138 |
| B | THR194 |
| B | THR195 |
| B | PRO264 |
| B | GLN269 |
| B | ASN291 |
| B | GLY293 |
| B | ARG294 |
| B | HOH329 |
| B | HOH335 |
| B | HOH343 |
| B | HOH348 |
| B | HOH356 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG A 2000 |
| Chain | Residue |
| A | ASN299 |
| A | PRO300 |
| A | MET308 |
| A | GLN312 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 B 3000 |
| Chain | Residue |
| B | LYS147 |
| B | ARG150 |
| B | ASP179 |
| B | GLU180 |
| B | GLU181 |
| B | HOH475 |
Functional Information from PROSITE/UniProt
| site_id | PS00156 |
| Number of Residues | 14 |
| Details | OMPDECASE Orotidine 5'-phosphate decarboxylase active site. TIlDmKinDIGnTV |
| Chain | Residue | Details |
| A | THR133-VAL146 |
