3LOG
Crystal structure of MbtI from Mycobacterium tuberculosis
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000162 | biological_process | tryptophan biosynthetic process |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0004106 | molecular_function | chorismate mutase activity |
A | 0005886 | cellular_component | plasma membrane |
A | 0008909 | molecular_function | isochorismate synthase activity |
A | 0009058 | biological_process | biosynthetic process |
A | 0009697 | biological_process | salicylic acid biosynthetic process |
A | 0010106 | biological_process | cellular response to iron ion starvation |
A | 0016829 | molecular_function | lyase activity |
A | 0016833 | molecular_function | oxo-acid-lyase activity |
A | 0016853 | molecular_function | isomerase activity |
A | 0019540 | biological_process | catechol-containing siderophore biosynthetic process |
A | 0043904 | molecular_function | isochorismate pyruvate lyase activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0052572 | biological_process | response to host immune response |
B | 0000162 | biological_process | tryptophan biosynthetic process |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0004106 | molecular_function | chorismate mutase activity |
B | 0005886 | cellular_component | plasma membrane |
B | 0008909 | molecular_function | isochorismate synthase activity |
B | 0009058 | biological_process | biosynthetic process |
B | 0009697 | biological_process | salicylic acid biosynthetic process |
B | 0010106 | biological_process | cellular response to iron ion starvation |
B | 0016829 | molecular_function | lyase activity |
B | 0016833 | molecular_function | oxo-acid-lyase activity |
B | 0016853 | molecular_function | isomerase activity |
B | 0019540 | biological_process | catechol-containing siderophore biosynthetic process |
B | 0043904 | molecular_function | isochorismate pyruvate lyase activity |
B | 0046872 | molecular_function | metal ion binding |
B | 0052572 | biological_process | response to host immune response |
C | 0000162 | biological_process | tryptophan biosynthetic process |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0004106 | molecular_function | chorismate mutase activity |
C | 0005886 | cellular_component | plasma membrane |
C | 0008909 | molecular_function | isochorismate synthase activity |
C | 0009058 | biological_process | biosynthetic process |
C | 0009697 | biological_process | salicylic acid biosynthetic process |
C | 0010106 | biological_process | cellular response to iron ion starvation |
C | 0016829 | molecular_function | lyase activity |
C | 0016833 | molecular_function | oxo-acid-lyase activity |
C | 0016853 | molecular_function | isomerase activity |
C | 0019540 | biological_process | catechol-containing siderophore biosynthetic process |
C | 0043904 | molecular_function | isochorismate pyruvate lyase activity |
C | 0046872 | molecular_function | metal ion binding |
C | 0052572 | biological_process | response to host immune response |
D | 0000162 | biological_process | tryptophan biosynthetic process |
D | 0000287 | molecular_function | magnesium ion binding |
D | 0004106 | molecular_function | chorismate mutase activity |
D | 0005886 | cellular_component | plasma membrane |
D | 0008909 | molecular_function | isochorismate synthase activity |
D | 0009058 | biological_process | biosynthetic process |
D | 0009697 | biological_process | salicylic acid biosynthetic process |
D | 0010106 | biological_process | cellular response to iron ion starvation |
D | 0016829 | molecular_function | lyase activity |
D | 0016833 | molecular_function | oxo-acid-lyase activity |
D | 0016853 | molecular_function | isomerase activity |
D | 0019540 | biological_process | catechol-containing siderophore biosynthetic process |
D | 0043904 | molecular_function | isochorismate pyruvate lyase activity |
D | 0046872 | molecular_function | metal ion binding |
D | 0052572 | biological_process | response to host immune response |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE SIN A 450 |
Chain | Residue |
A | TYR385 |
A | LEU404 |
A | ARG405 |
A | ALA418 |
A | GLY419 |
A | LYS438 |
A | HOH468 |
A | HOH604 |
A | HOH627 |
site_id | AC2 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE SIN A 451 |
Chain | Residue |
A | ARG382 |
A | GLY383 |
A | LEU384 |
A | TYR385 |
A | TYR408 |
A | TRP415 |
A | HOH529 |
A | HOH996 |
A | HOH1271 |
site_id | AC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 452 |
Chain | Residue |
A | GLY270 |
A | GLU294 |
A | GLU297 |
A | GLY421 |
A | HOH517 |
A | HOH546 |
A | HOH1185 |
A | HOH1443 |
site_id | AC4 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE SIN B 450 |
Chain | Residue |
B | THR361 |
B | TYR385 |
B | ARG405 |
B | ALA418 |
B | GLY419 |
B | LYS438 |
B | CO3452 |
B | HOH494 |
B | HOH557 |
B | HOH582 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NA B 451 |
Chain | Residue |
B | LYS293 |
B | GLU297 |
B | GLY421 |
B | GLU431 |
B | GLU434 |
B | CO3452 |
B | HOH648 |
site_id | AC6 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE CO3 B 452 |
Chain | Residue |
B | GLY270 |
B | THR271 |
B | GLU297 |
B | GLY421 |
B | GLU434 |
B | LYS438 |
B | SIN450 |
B | NA451 |
B | HOH558 |
site_id | AC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL B 453 |
Chain | Residue |
B | VAL214 |
B | PHE216 |
B | ALA217 |
B | GLY412 |
B | ARG413 |
B | THR414 |
B | HOH618 |
site_id | AC8 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE SIN C 450 |
Chain | Residue |
C | THR361 |
C | TYR385 |
C | LEU404 |
C | ARG405 |
C | ALA418 |
C | GLY419 |
C | LYS438 |
C | HOH1399 |
C | HOH1490 |
site_id | AC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL C 451 |
Chain | Residue |
C | VAL214 |
C | PRO215 |
C | PHE216 |
C | ALA217 |
C | GLY412 |
C | THR414 |
C | HOH538 |
site_id | BC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL C 452 |
Chain | Residue |
C | ARG80 |
C | ARG81 |
C | HOH1533 |
site_id | BC2 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE SIN D 450 |
Chain | Residue |
D | THR361 |
D | TYR385 |
D | LEU404 |
D | ARG405 |
D | ALA418 |
D | GLY419 |
D | LYS438 |
D | HOH716 |
D | HOH1558 |
site_id | BC3 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL D 451 |
Chain | Residue |
D | ARG382 |
D | GLY383 |
D | LEU384 |
D | TYR385 |
D | TYR408 |
D | TRP415 |
D | HOH503 |
D | HOH1206 |
D | HOH1394 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q9X9I8 |
Chain | Residue | Details |
A | GLU252 | |
B | GLU252 | |
C | GLU252 | |
D | GLU252 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:20512795, ECO:0000269|PubMed:22607697 |
Chain | Residue | Details |
A | GLY270 | |
B | GLY270 | |
C | GLY270 | |
D | GLY270 |
site_id | SWS_FT_FI3 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:20512795 |
Chain | Residue | Details |
A | GLU297 | |
A | GLU431 | |
A | GLU434 | |
B | GLU297 | |
B | GLU431 | |
B | GLU434 | |
C | GLU297 | |
C | GLU431 | |
C | GLU434 | |
D | GLU297 | |
D | GLU431 | |
D | GLU434 |
site_id | SWS_FT_FI4 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16923875, ECO:0000269|PubMed:20512795, ECO:0000269|PubMed:22607697 |
Chain | Residue | Details |
B | TYR385 | |
B | ARG405 | |
B | GLY419 | |
B | LYS438 | |
C | TYR385 | |
C | ARG405 | |
C | GLY419 | |
C | LYS438 | |
D | TYR385 | |
D | ARG405 | |
D | GLY419 | |
D | LYS438 | |
A | TYR385 | |
A | ARG405 | |
A | GLY419 | |
A | LYS438 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | SITE: Could activate a water molecule for attack at the C2 of chorismate and involved in recognition/elimination of the C4 hydroxyl => ECO:0000269|PubMed:17240979 |
Chain | Residue | Details |
A | LEU268 | |
B | LEU268 | |
C | LEU268 | |
D | LEU268 |