3L03
Crystal Structure of human Estrogen Receptor alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II peptide and Estetrol (Estra-1,3,5(10)-triene-3,15 alpha,16alpha,17beta-tetrol)
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 1 |
| Chain | Residue |
| A | HOH18 |
| A | HOH54 |
| A | ARG352 |
| B | ARG352 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 2 |
| Chain | Residue |
| A | ASN439 |
| A | GLN441 |
| A | GLU444 |
| A | ALA493 |
| A | LEU495 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 4OH A 551 |
| Chain | Residue |
| A | HOH3 |
| A | MET343 |
| A | LEU346 |
| A | GLU353 |
| A | LEU387 |
| A | MET388 |
| A | ARG394 |
| A | PHE404 |
| A | ILE424 |
| A | GLY521 |
| A | HIS524 |
| A | LEU525 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 4OH B 2 |
| Chain | Residue |
| B | HOH23 |
| B | MET343 |
| B | LEU346 |
| B | GLU353 |
| B | LEU387 |
| B | ARG394 |
| B | ILE424 |
| B | GLY521 |
| B | HIS524 |
| B | LEU525 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | SER537 | |
| B | SER537 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS447 | |
| B | CYS447 | |
